ZNF189 (zinc finger protein 189)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7743
• Gene name: Zinc finger protein 189
• Gene symbol: ZNF189
• Synonyms (NCBI Gene): -
• Chromosome: 9
• Chromosome location: 9q31.1
• Summary: Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approxi

miRNA Show/Hide all (62)

miRTarBase ID	miRNA	Experiments	Reference
MIRT571042	hsa-miR-6512-5p	PAR-CLIP	20371350
MIRT571041	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT571040	hsa-miR-589-3p	PAR-CLIP	20371350
MIRT571039	hsa-miR-3622b-5p	PAR-CLIP	20371350
MIRT571042	hsa-miR-6512-5p	PAR-CLIP	20371350
MIRT571041	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT571040	hsa-miR-589-3p	PAR-CLIP	20371350
MIRT571039	hsa-miR-3622b-5p	PAR-CLIP	20371350
MIRT1517345	hsa-miR-105	CLIP-seq
MIRT1517346	hsa-miR-1225-5p	CLIP-seq
MIRT1517347	hsa-miR-1271	CLIP-seq
MIRT1517348	hsa-miR-1290	CLIP-seq
MIRT1517349	hsa-miR-182	CLIP-seq
MIRT1517350	hsa-miR-2467-3p	CLIP-seq
MIRT1517351	hsa-miR-27a	CLIP-seq
MIRT1517352	hsa-miR-27b	CLIP-seq
MIRT1517353	hsa-miR-302f	CLIP-seq
MIRT1517354	hsa-miR-3614-5p	CLIP-seq
MIRT1517355	hsa-miR-3654	CLIP-seq
MIRT1517356	hsa-miR-3678-3p	CLIP-seq
MIRT1517357	hsa-miR-378	CLIP-seq
MIRT1517358	hsa-miR-378b	CLIP-seq
MIRT1517359	hsa-miR-378c	CLIP-seq
MIRT1517360	hsa-miR-378d	CLIP-seq
MIRT1517361	hsa-miR-378e	CLIP-seq
MIRT1517362	hsa-miR-378f	CLIP-seq
MIRT1517363	hsa-miR-378h	CLIP-seq
MIRT1517364	hsa-miR-378i	CLIP-seq
MIRT1517365	hsa-miR-3923	CLIP-seq
MIRT1517366	hsa-miR-422a	CLIP-seq
MIRT1517367	hsa-miR-4325	CLIP-seq
MIRT1517368	hsa-miR-4474-5p	CLIP-seq
MIRT1517369	hsa-miR-4642	CLIP-seq
MIRT1517370	hsa-miR-4793-3p	CLIP-seq
MIRT1517371	hsa-miR-513a-5p	CLIP-seq
MIRT1517372	hsa-miR-548a-3p	CLIP-seq
MIRT1517373	hsa-miR-548e	CLIP-seq
MIRT1517374	hsa-miR-548f	CLIP-seq
MIRT1517375	hsa-miR-96	CLIP-seq
MIRT1517351	hsa-miR-27a	CLIP-seq
MIRT1517352	hsa-miR-27b	CLIP-seq
MIRT1517371	hsa-miR-513a-5p	CLIP-seq
MIRT2375783	hsa-miR-1292	CLIP-seq
MIRT1517350	hsa-miR-2467-3p	CLIP-seq
MIRT2375784	hsa-miR-3192	CLIP-seq
MIRT1517356	hsa-miR-3678-3p	CLIP-seq
MIRT2375785	hsa-miR-376a	CLIP-seq
MIRT2375786	hsa-miR-376b	CLIP-seq
MIRT2375787	hsa-miR-4314	CLIP-seq
MIRT2375788	hsa-miR-4471	CLIP-seq
MIRT2375789	hsa-miR-4646-5p	CLIP-seq
MIRT1517346	hsa-miR-1225-5p	CLIP-seq
MIRT2668280	hsa-miR-3613-3p	CLIP-seq
MIRT1517354	hsa-miR-3614-5p	CLIP-seq
MIRT1517365	hsa-miR-3923	CLIP-seq
MIRT1517367	hsa-miR-4325	CLIP-seq
MIRT2668281	hsa-miR-4635	CLIP-seq
MIRT2668282	hsa-miR-4716-5p	CLIP-seq
MIRT1517370	hsa-miR-4793-3p	CLIP-seq
MIRT1517372	hsa-miR-548a-3p	CLIP-seq
MIRT1517373	hsa-miR-548e	CLIP-seq
MIRT1517374	hsa-miR-548f	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009891	Process	Positive regulation of biosynthetic process	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 603132
• HGNC: 12980
• e!Ensembl: ENSG00000136870

Protein

• UniProt ID: O75820
• Protein name: Zinc finger protein 189
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	204 → 226	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	372 → 394	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	400 → 422	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	540 → 562	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	568 → 590	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	456 → 478	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	484 → 506	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	176 → 198	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	288 → 310	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	232 → 254	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	148 → 170	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	260 → 282	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	344 → 366	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	316 → 338	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	512 → 534	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	13 → 54	KRAB box	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MASPSPPPESKGLLTFEDVAVFFTQEEWDYLDPAQRSLYKDVMMENYGNLVSLDVLNRDK
  DEEPTVKQEIEEIEEEVEPQGVIVTRIKSEIDQDPMGRETFELVGRLDKQRGIFLWEIPR
  ESLTQEQRMFRENTNIIRKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCNE
  CGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQS
  FSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRN
  SLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLI
  EHQRIHTGERPYQCKECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQR
  IHTREKTYPYNETKESFDPNCSLVIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQRIHTG
  EKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPH
  KCDECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDKSFSQQRSLVNHQKIHAEVKTQETHE
  CDACGEAFNCRISLIQHQKLHTAWMQ

• Sequence length: 626

Pathways

Reactome Pathway:

Generic Transcription Pathway

Related Genes

No strongly related genes found yet for ZNF189.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF189.