Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	7700
Gene name	Zinc finger protein 141
Gene symbol	ZNF141
Synonyms (NCBI Gene)	D4S90pHZ-44
Chromosome	4
Chromosome location	4p16.3
Summary	The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]

SNP ID	Visualize variation	Clinical significance	Consequence
rs587776959	C>T	Pathogenic-likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant, intron variant

70 Show/Hide all (70)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028830	hsa-miR-26b-5p	Microarray	19088304
MIRT650461	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT650460	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT650459	hsa-miR-940	HITS-CLIP	23824327
MIRT650458	hsa-miR-3929	HITS-CLIP	23824327
MIRT650457	hsa-miR-4419b	HITS-CLIP	23824327
MIRT650456	hsa-miR-4478	HITS-CLIP	23824327
MIRT519276	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT650455	hsa-miR-6078	HITS-CLIP	23824327
MIRT650454	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT650453	hsa-miR-1827	HITS-CLIP	23824327
MIRT519272	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT650452	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT650451	hsa-miR-665	HITS-CLIP	23824327
MIRT519277	hsa-miR-302f	PAR-CLIP	23446348
MIRT519276	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT519275	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT519274	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT519273	hsa-miR-6134	PAR-CLIP	23446348
MIRT519272	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT519271	hsa-miR-6880-5p	PAR-CLIP	23446348
MIRT519270	hsa-miR-7847-3p	PAR-CLIP	23446348
MIRT519269	hsa-miR-1273e	PAR-CLIP	23446348
MIRT650461	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT650460	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT650459	hsa-miR-940	HITS-CLIP	23824327
MIRT650458	hsa-miR-3929	HITS-CLIP	23824327
MIRT650457	hsa-miR-4419b	HITS-CLIP	23824327
MIRT650456	hsa-miR-4478	HITS-CLIP	23824327
MIRT519276	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT650455	hsa-miR-6078	HITS-CLIP	23824327
MIRT650454	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT650453	hsa-miR-1827	HITS-CLIP	23824327
MIRT519272	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT650452	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT650451	hsa-miR-665	HITS-CLIP	23824327
MIRT519277	hsa-miR-302f	PAR-CLIP	23446348
MIRT519276	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT519275	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT519274	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT519273	hsa-miR-6134	PAR-CLIP	23446348
MIRT519272	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT519271	hsa-miR-6880-5p	PAR-CLIP	23446348
MIRT519270	hsa-miR-7847-3p	PAR-CLIP	23446348
MIRT519269	hsa-miR-1273e	PAR-CLIP	23446348
MIRT1516572	hsa-miR-3064-3p	CLIP-seq
MIRT1516573	hsa-miR-3159	CLIP-seq
MIRT1516574	hsa-miR-3167	CLIP-seq
MIRT1516575	hsa-miR-3674	CLIP-seq
MIRT1516576	hsa-miR-4464	CLIP-seq
MIRT1516577	hsa-miR-4715-3p	CLIP-seq
MIRT1516578	hsa-miR-4748	CLIP-seq
MIRT1516579	hsa-miR-4776-3p	CLIP-seq
MIRT1516580	hsa-miR-876-5p	CLIP-seq
MIRT1516572	hsa-miR-3064-3p	CLIP-seq
MIRT1516573	hsa-miR-3159	CLIP-seq
MIRT1516575	hsa-miR-3674	CLIP-seq
MIRT1516576	hsa-miR-4464	CLIP-seq
MIRT1516577	hsa-miR-4715-3p	CLIP-seq
MIRT1516578	hsa-miR-4748	CLIP-seq
MIRT1516579	hsa-miR-4776-3p	CLIP-seq
MIRT1516572	hsa-miR-3064-3p	CLIP-seq
MIRT1516573	hsa-miR-3159	CLIP-seq
MIRT1516574	hsa-miR-3167	CLIP-seq
MIRT1516575	hsa-miR-3674	CLIP-seq
MIRT1516576	hsa-miR-4464	CLIP-seq
MIRT1516577	hsa-miR-4715-3p	CLIP-seq
MIRT1516578	hsa-miR-4748	CLIP-seq
MIRT1516579	hsa-miR-4776-3p	CLIP-seq
MIRT1516580	hsa-miR-876-5p	CLIP-seq

13 Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	7649249
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006366	Process	Transcription by RNA polymerase II	TAS	8268908
GO:0008270	Function	Zinc ion binding	IEA
GO:0009653	Process	Anatomical structure morphogenesis	TAS	8268908
GO:0035108	Process	Limb morphogenesis	IMP	23160277
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
194648	12926	ENSG00000131127

Q15928

Protein name

Zinc finger protein 141

Protein function

May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00096	zf-C2H2	311 → 333	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	451 → 473	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	339 → 361	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	255 → 277	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	423 → 445	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	283 → 305	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	227 → 249	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	395 → 417	Zinc finger, C2H2 type	Domain
PF01352	KRAB	3 → 44	KRAB box	Family
PF13912	zf-C2H2_6	367 → 392		Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously low expression.

Sequence

MELLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLGVAISNPDLVTCLEQRK
EPYNVKIHKIVARPPAMCSHFTQDHWPVQGIEDSFHKLILRRYEKCGHDNLQLRKGCKSL
NECKLQKGGYNEFNECLSTTQSKILQCKASVKVVSKFSNSNKRKTRHTGEKHFKECGKSF
QKFSHLTQHKVIHAGEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSS
HFAKHKIIHTGEKPYKCEECGKAFNRFTTLTKHKRIHAGEKPITCEECRKIFTSSSNFAK
HKRIHTGEKPYKCEECGKAFNRSTTLTKHKRIHTGEKPYTCEECGKAFRQSSKLNEHKKV
HTGERPYKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDRSQHKKIHSAD
KPYKCKECDKAFKQFSLLSQHKKIHTVDKPYKCKDCDKAFKRFSHLNKHKKIHT

Sequence length

474

Interactions

View interactions

Reactome Pathway
Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Polydactyly, postaxial, type A6	Likely pathogenic; Pathogenic	rs587776959	RCV000043502	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
POSTAXIAL POLYDACTYLY TYPE A	—	Disgenet Disgenet	26394607, 23160277	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ZNF141-related disorder	Benign; Uncertain significance; Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (12)
Huntington Disease	Huntington Disease	BEFREE	1350884, 1829583, 2521771, 2531224, 2574148, 7760321		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intestinal Diseases	Intestinal disease	Pubtator	17071588	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polydactyly	Polydactyly	GENOMICS_ENGLAND_DG	23160277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polydactyly	Polydactyly	Pubtator	28488682, 31115189	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
POLYDACTYLY, POSTAXIAL	Polydactyly	BEFREE	23160277		★★★★★ ★☆☆☆☆ Found in Text Mining only
POLYDACTYLY, POSTAXIAL, TYPE A6	Polydactyly	UNIPROT_DG	23160277		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
POLYDACTYLY, POSTAXIAL, TYPE A6	Polydactyly	GENOMICS_ENGLAND_DG	23160277		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
POLYDACTYLY, POSTAXIAL, TYPE A6	Polydactyly	CLINVAR_DG	23160277		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Postaxial polydactyly type A	Polydactyly	ORPHANET_DG	23160277, 26394607		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Postaxial polydactyly type A	Polydactyly	BEFREE	23160277		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ulnar polydactyly of fingers	Postaxial hand polydactyly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Wolf-Hirschhorn Syndrome	Wolf-Hirschhorn Syndrome	BEFREE	8268908		★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF141 (zinc finger protein 141)

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