ZNF140 (zinc finger protein 140)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7699
• Gene name: Zinc finger protein 140
• Gene symbol: ZNF140
• Synonyms (NCBI Gene): pHZ-39
• Chromosome: 12
• Chromosome location: 12q24.33

miRNA Show/Hide all (90)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029054	hsa-miR-26b-5p	Microarray	19088304
MIRT1516546	hsa-miR-1264	CLIP-seq
MIRT1516547	hsa-miR-3149	CLIP-seq
MIRT1516548	hsa-miR-323-3p	CLIP-seq
MIRT1516549	hsa-miR-34c-3p	CLIP-seq
MIRT1516550	hsa-miR-3646	CLIP-seq
MIRT1516551	hsa-miR-4475	CLIP-seq
MIRT1516552	hsa-miR-4517	CLIP-seq
MIRT1516553	hsa-miR-4720-3p	CLIP-seq
MIRT1516554	hsa-miR-4804-3p	CLIP-seq
MIRT1516555	hsa-miR-513c	CLIP-seq
MIRT1516556	hsa-miR-514b-5p	CLIP-seq
MIRT1516557	hsa-miR-548a-5p	CLIP-seq
MIRT1516558	hsa-miR-548ab	CLIP-seq
MIRT1516559	hsa-miR-548ak	CLIP-seq
MIRT1516560	hsa-miR-548b-5p	CLIP-seq
MIRT1516561	hsa-miR-548c-5p	CLIP-seq
MIRT1516562	hsa-miR-548d-5p	CLIP-seq
MIRT1516563	hsa-miR-548h	CLIP-seq
MIRT1516564	hsa-miR-548i	CLIP-seq
MIRT1516565	hsa-miR-548j	CLIP-seq
MIRT1516566	hsa-miR-548k	CLIP-seq
MIRT1516567	hsa-miR-548l	CLIP-seq
MIRT1516568	hsa-miR-548w	CLIP-seq
MIRT1516569	hsa-miR-548y	CLIP-seq
MIRT1516570	hsa-miR-559	CLIP-seq
MIRT1516571	hsa-miR-942	CLIP-seq
MIRT1922523	hsa-miR-3910	CLIP-seq
MIRT2155877	hsa-miR-106a	CLIP-seq
MIRT2155878	hsa-miR-106b	CLIP-seq
MIRT2155879	hsa-miR-128	CLIP-seq
MIRT2155880	hsa-miR-142-5p	CLIP-seq
MIRT2155881	hsa-miR-17	CLIP-seq
MIRT2155882	hsa-miR-20a	CLIP-seq
MIRT2155883	hsa-miR-20b	CLIP-seq
MIRT2155884	hsa-miR-23a	CLIP-seq
MIRT2155885	hsa-miR-23b	CLIP-seq
MIRT2155886	hsa-miR-23c	CLIP-seq
MIRT2155887	hsa-miR-27a	CLIP-seq
MIRT2155888	hsa-miR-27b	CLIP-seq
MIRT2155889	hsa-miR-3609	CLIP-seq
MIRT2155890	hsa-miR-3682-5p	CLIP-seq
MIRT2155891	hsa-miR-4265	CLIP-seq
MIRT2155892	hsa-miR-4296	CLIP-seq
MIRT2155893	hsa-miR-4322	CLIP-seq
MIRT2155894	hsa-miR-4417	CLIP-seq
MIRT2155895	hsa-miR-4640-5p	CLIP-seq
MIRT2155896	hsa-miR-4726-5p	CLIP-seq
MIRT2155897	hsa-miR-4762-3p	CLIP-seq
MIRT2155898	hsa-miR-4796-3p	CLIP-seq
MIRT2155899	hsa-miR-513a-5p	CLIP-seq
MIRT2155900	hsa-miR-519d	CLIP-seq
MIRT2155901	hsa-miR-548ah	CLIP-seq
MIRT2155902	hsa-miR-595	CLIP-seq
MIRT2155903	hsa-miR-93	CLIP-seq
MIRT2375576	hsa-miR-3160-5p	CLIP-seq
MIRT2375577	hsa-miR-4729	CLIP-seq
MIRT2375578	hsa-miR-4789-5p	CLIP-seq
MIRT2375579	hsa-miR-579	CLIP-seq
MIRT2375580	hsa-miR-582-5p	CLIP-seq
MIRT2375581	hsa-miR-664	CLIP-seq
MIRT1516547	hsa-miR-3149	CLIP-seq
MIRT2667907	hsa-miR-124	CLIP-seq
MIRT2667908	hsa-miR-2117	CLIP-seq
MIRT2155884	hsa-miR-23a	CLIP-seq
MIRT2155885	hsa-miR-23b	CLIP-seq
MIRT2155886	hsa-miR-23c	CLIP-seq
MIRT2667909	hsa-miR-3124-3p	CLIP-seq
MIRT2667910	hsa-miR-3714	CLIP-seq
MIRT1922523	hsa-miR-3910	CLIP-seq
MIRT2667911	hsa-miR-3921	CLIP-seq
MIRT2667912	hsa-miR-4653-5p	CLIP-seq
MIRT2667913	hsa-miR-506	CLIP-seq
MIRT2695744	hsa-miR-1261	CLIP-seq
MIRT2695745	hsa-miR-149	CLIP-seq
MIRT2695746	hsa-miR-190	CLIP-seq
MIRT2695747	hsa-miR-190b	CLIP-seq
MIRT2695748	hsa-miR-216a	CLIP-seq
MIRT2695749	hsa-miR-216b	CLIP-seq
MIRT2695750	hsa-miR-3064-5p	CLIP-seq
MIRT2695751	hsa-miR-3119	CLIP-seq
MIRT2375576	hsa-miR-3160-5p	CLIP-seq
MIRT2695752	hsa-miR-3201	CLIP-seq
MIRT2695753	hsa-miR-326	CLIP-seq
MIRT2695754	hsa-miR-330-5p	CLIP-seq
MIRT2695755	hsa-miR-3616-3p	CLIP-seq
MIRT2695756	hsa-miR-4721	CLIP-seq
MIRT2695757	hsa-miR-4791	CLIP-seq
MIRT2695758	hsa-miR-4794	CLIP-seq
MIRT2695759	hsa-miR-515-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	7649249, 11470777
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	11470777
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0043565	Function	Sequence-specific DNA binding	IDA	28473536
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 604082
• HGNC: 12925
• e!Ensembl: ENSG00000196387

Protein

• UniProt ID: P52738
• Protein name: Zinc finger protein 140
• Protein function: May be involved in transcriptional regulation as a repressor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	245 → 267	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	189 → 211	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	413 → 435	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	385 → 407	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	273 → 295	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	161 → 183	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	217 → 239	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	301 → 323	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	5 → 46	KRAB box	Family
  PF13912	zf-C2H2_6	356 → 382		Domain

• Tissue specificity: TISSUE SPECIFICITY: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
• Sequence:

  MSQGSVTFRDVAIDFSQEEWKWLQPAQRDLYRCVMLENYGHLVSLGLSISKPDVVSLLEQ
  GKEPWLGKREVKRDLFSVSESSGEIKDFSPKNVIYDDSSQYLIMERILSQGPVYSSFKGG
  WKCKDHTEMLQENQGCIRKVTVSHQEALAQHMNISTVERPYGCHECGKTFGRRFSLVLHQ
  RTHTGEKPYACKECGKTFSQISNLVKHQMIHTGKKPHECKDCNKTFSYLSFLIEHQRTHT
  GEKPYECTECGKAFSRASNLTRHQRIHIGKKQYICRKCGKAFSSGSELIRHQITHTGEKP
  YECIECGKAFRRFSHLTRHQSIHTTKTPYECNECRKAFRCHSFLIKHQRIHAGEKLYECD
  ECGKVFTWHASLIQHTKSHTGEKPYACAECDKAFSRSFSLILHQRTHTGEKPYVCKVCNK
  SFSWSSNLAKHQRTHTLDNPYEYENSFNYHSFLTEHQ

• Sequence length: 457

Pathways

Reactome Pathway:

Generic Transcription Pathway

Related Genes

No strongly related genes found yet for ZNF140.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF140.