ZNF136 (zinc finger protein 136)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7695
• Gene name: Zinc finger protein 136
• Gene symbol: ZNF136
• Synonyms (NCBI Gene): pHZ-20
• Chromosome: 19
• Chromosome location: 19p13.2
• Summary: This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor

miRNA Show/Hide all (244)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029729	hsa-miR-26b-5p	Microarray	19088304
MIRT552498	hsa-miR-1276	PAR-CLIP	21572407
MIRT552497	hsa-miR-5692a	PAR-CLIP	21572407
MIRT552496	hsa-miR-2278	PAR-CLIP	21572407
MIRT552495	hsa-miR-300	PAR-CLIP	21572407
MIRT552494	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT552493	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT552492	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT552491	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT552490	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT552489	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT552488	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT552487	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT552486	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT552485	hsa-let-7f-2-3p	PAR-CLIP	21572407
MIRT552484	hsa-miR-1185-1-3p	PAR-CLIP	21572407
MIRT552483	hsa-miR-1185-2-3p	PAR-CLIP	21572407
MIRT541013	hsa-miR-6771-3p	PAR-CLIP	21572407
MIRT541012	hsa-miR-28-3p	PAR-CLIP	21572407
MIRT541011	hsa-miR-5680	PAR-CLIP	21572407
MIRT541010	hsa-miR-3675-3p	PAR-CLIP	21572407
MIRT541009	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT541008	hsa-miR-6508-5p	PAR-CLIP	21572407
MIRT541006	hsa-miR-8067	PAR-CLIP	21572407
MIRT541007	hsa-miR-4684-5p	PAR-CLIP	21572407
MIRT541013	hsa-miR-6771-3p	PAR-CLIP	21572407
MIRT541012	hsa-miR-28-3p	PAR-CLIP	21572407
MIRT541011	hsa-miR-5680	PAR-CLIP	21572407
MIRT541010	hsa-miR-3675-3p	PAR-CLIP	21572407
MIRT541009	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT541008	hsa-miR-6508-5p	PAR-CLIP	21572407
MIRT541006	hsa-miR-8067	PAR-CLIP	21572407
MIRT541007	hsa-miR-4684-5p	PAR-CLIP	21572407
MIRT149977	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT149978	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT149979	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT149981	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT552498	hsa-miR-1276	PAR-CLIP	21572407
MIRT552497	hsa-miR-5692a	PAR-CLIP	21572407
MIRT552496	hsa-miR-2278	PAR-CLIP	21572407
MIRT552495	hsa-miR-300	PAR-CLIP	21572407
MIRT552494	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT552493	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT552492	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT552491	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT552490	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT552489	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT552488	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT552487	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT552486	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT552485	hsa-let-7f-2-3p	PAR-CLIP	21572407
MIRT552484	hsa-miR-1185-1-3p	PAR-CLIP	21572407
MIRT552483	hsa-miR-1185-2-3p	PAR-CLIP	21572407
MIRT541013	hsa-miR-6771-3p	PAR-CLIP	21572407
MIRT541012	hsa-miR-28-3p	PAR-CLIP	21572407
MIRT541011	hsa-miR-5680	PAR-CLIP	21572407
MIRT541010	hsa-miR-3675-3p	PAR-CLIP	21572407
MIRT541009	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT541008	hsa-miR-6508-5p	PAR-CLIP	21572407
MIRT541006	hsa-miR-8067	PAR-CLIP	21572407
MIRT541007	hsa-miR-4684-5p	PAR-CLIP	21572407
MIRT541013	hsa-miR-6771-3p	PAR-CLIP	21572407
MIRT541012	hsa-miR-28-3p	PAR-CLIP	21572407
MIRT541011	hsa-miR-5680	PAR-CLIP	21572407
MIRT541010	hsa-miR-3675-3p	PAR-CLIP	21572407
MIRT541009	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT541008	hsa-miR-6508-5p	PAR-CLIP	21572407
MIRT541006	hsa-miR-8067	PAR-CLIP	21572407
MIRT541007	hsa-miR-4684-5p	PAR-CLIP	21572407
MIRT1516437	hsa-miR-1245	CLIP-seq
MIRT1516438	hsa-miR-181a	CLIP-seq
MIRT1516439	hsa-miR-181b	CLIP-seq
MIRT1516440	hsa-miR-181c	CLIP-seq
MIRT1516441	hsa-miR-181d	CLIP-seq
MIRT1516442	hsa-miR-1976	CLIP-seq
MIRT1516443	hsa-miR-2467-5p	CLIP-seq
MIRT1516444	hsa-miR-3074-3p	CLIP-seq
MIRT1516445	hsa-miR-3119	CLIP-seq
MIRT1516446	hsa-miR-3158-3p	CLIP-seq
MIRT1516447	hsa-miR-3159	CLIP-seq
MIRT1516448	hsa-miR-3188	CLIP-seq
MIRT1516449	hsa-miR-371-5p	CLIP-seq
MIRT1516450	hsa-miR-371b-5p	CLIP-seq
MIRT1516451	hsa-miR-376a	CLIP-seq
MIRT1516452	hsa-miR-376b	CLIP-seq
MIRT1516453	hsa-miR-3934	CLIP-seq
MIRT1516454	hsa-miR-3942-3p	CLIP-seq
MIRT1516455	hsa-miR-3975	CLIP-seq
MIRT1516456	hsa-miR-4262	CLIP-seq
MIRT1516457	hsa-miR-4446-3p	CLIP-seq
MIRT1516458	hsa-miR-4700-3p	CLIP-seq
MIRT1516459	hsa-miR-4722-3p	CLIP-seq
MIRT1516460	hsa-miR-485-5p	CLIP-seq
MIRT1516461	hsa-miR-5095	CLIP-seq
MIRT1516462	hsa-miR-552	CLIP-seq
MIRT1516463	hsa-miR-586	CLIP-seq
MIRT1516464	hsa-miR-600	CLIP-seq
MIRT2155830	hsa-miR-106a	CLIP-seq
MIRT2155831	hsa-miR-106b	CLIP-seq
MIRT1516437	hsa-miR-1245	CLIP-seq
MIRT2155832	hsa-miR-17	CLIP-seq
MIRT1516438	hsa-miR-181a	CLIP-seq
MIRT1516439	hsa-miR-181b	CLIP-seq
MIRT1516440	hsa-miR-181c	CLIP-seq
MIRT1516441	hsa-miR-181d	CLIP-seq
MIRT1516442	hsa-miR-1976	CLIP-seq
MIRT2155833	hsa-miR-20a	CLIP-seq
MIRT2155834	hsa-miR-20b	CLIP-seq
MIRT2155835	hsa-miR-2113	CLIP-seq
MIRT2155836	hsa-miR-302a	CLIP-seq
MIRT2155837	hsa-miR-302b	CLIP-seq
MIRT2155838	hsa-miR-302c	CLIP-seq
MIRT2155839	hsa-miR-302d	CLIP-seq
MIRT2155840	hsa-miR-302e	CLIP-seq
MIRT2155841	hsa-miR-3160-5p	CLIP-seq
MIRT2155842	hsa-miR-335	CLIP-seq
MIRT2155843	hsa-miR-372	CLIP-seq
MIRT2155844	hsa-miR-373	CLIP-seq
MIRT1516453	hsa-miR-3934	CLIP-seq
MIRT1516456	hsa-miR-4262	CLIP-seq
MIRT2155845	hsa-miR-4272	CLIP-seq
MIRT2155846	hsa-miR-4422	CLIP-seq
MIRT1516459	hsa-miR-4722-3p	CLIP-seq
MIRT2155847	hsa-miR-4731-5p	CLIP-seq
MIRT2155848	hsa-miR-4753-3p	CLIP-seq
MIRT2155849	hsa-miR-4768-5p	CLIP-seq
MIRT1516461	hsa-miR-5095	CLIP-seq
MIRT2155850	hsa-miR-512-3p	CLIP-seq
MIRT2155851	hsa-miR-519d	CLIP-seq
MIRT2155852	hsa-miR-520a-3p	CLIP-seq
MIRT2155853	hsa-miR-520b	CLIP-seq
MIRT2155854	hsa-miR-520c-3p	CLIP-seq
MIRT2155855	hsa-miR-520d-3p	CLIP-seq
MIRT2155856	hsa-miR-520e	CLIP-seq
MIRT2155857	hsa-miR-520g	CLIP-seq
MIRT2155858	hsa-miR-520h	CLIP-seq
MIRT1516462	hsa-miR-552	CLIP-seq
MIRT2155859	hsa-miR-599	CLIP-seq
MIRT1516464	hsa-miR-600	CLIP-seq
MIRT2155860	hsa-miR-93	CLIP-seq
MIRT2155830	hsa-miR-106a	CLIP-seq
MIRT2155831	hsa-miR-106b	CLIP-seq
MIRT2375534	hsa-miR-1236	CLIP-seq
MIRT1516437	hsa-miR-1245	CLIP-seq
MIRT2375535	hsa-miR-1260	CLIP-seq
MIRT2375536	hsa-miR-1260b	CLIP-seq
MIRT2375537	hsa-miR-146a	CLIP-seq
MIRT2375538	hsa-miR-146b-5p	CLIP-seq
MIRT2375539	hsa-miR-150	CLIP-seq
MIRT2155832	hsa-miR-17	CLIP-seq
MIRT1516438	hsa-miR-181a	CLIP-seq
MIRT1516439	hsa-miR-181b	CLIP-seq
MIRT1516440	hsa-miR-181c	CLIP-seq
MIRT1516441	hsa-miR-181d	CLIP-seq
MIRT2375540	hsa-miR-188-3p	CLIP-seq
MIRT1516442	hsa-miR-1976	CLIP-seq
MIRT2375541	hsa-miR-203	CLIP-seq
MIRT2155833	hsa-miR-20a	CLIP-seq
MIRT2155834	hsa-miR-20b	CLIP-seq
MIRT2155835	hsa-miR-2113	CLIP-seq
MIRT2155836	hsa-miR-302a	CLIP-seq
MIRT2155837	hsa-miR-302b	CLIP-seq
MIRT2155838	hsa-miR-302c	CLIP-seq
MIRT2155839	hsa-miR-302d	CLIP-seq
MIRT2155840	hsa-miR-302e	CLIP-seq
MIRT1516444	hsa-miR-3074-3p	CLIP-seq
MIRT2375542	hsa-miR-3143	CLIP-seq
MIRT2375543	hsa-miR-3156-3p	CLIP-seq
MIRT1516446	hsa-miR-3158-3p	CLIP-seq
MIRT1516447	hsa-miR-3159	CLIP-seq
MIRT2155841	hsa-miR-3160-5p	CLIP-seq
MIRT2375544	hsa-miR-3174	CLIP-seq
MIRT2155842	hsa-miR-335	CLIP-seq
MIRT2375545	hsa-miR-3660	CLIP-seq
MIRT2155843	hsa-miR-372	CLIP-seq
MIRT2155844	hsa-miR-373	CLIP-seq
MIRT1516451	hsa-miR-376a	CLIP-seq
MIRT1516452	hsa-miR-376b	CLIP-seq
MIRT2375546	hsa-miR-3919	CLIP-seq
MIRT2375547	hsa-miR-3925-5p	CLIP-seq
MIRT1516453	hsa-miR-3934	CLIP-seq
MIRT1516454	hsa-miR-3942-3p	CLIP-seq
MIRT1516456	hsa-miR-4262	CLIP-seq
MIRT2155845	hsa-miR-4272	CLIP-seq
MIRT2375548	hsa-miR-4276	CLIP-seq
MIRT1516457	hsa-miR-4446-3p	CLIP-seq
MIRT2375549	hsa-miR-4503	CLIP-seq
MIRT2375550	hsa-miR-4517	CLIP-seq
MIRT2375551	hsa-miR-4526	CLIP-seq
MIRT1516458	hsa-miR-4700-3p	CLIP-seq
MIRT2375552	hsa-miR-4705	CLIP-seq
MIRT1516459	hsa-miR-4722-3p	CLIP-seq
MIRT2375553	hsa-miR-4729	CLIP-seq
MIRT2155847	hsa-miR-4731-5p	CLIP-seq
MIRT2155848	hsa-miR-4753-3p	CLIP-seq
MIRT2375554	hsa-miR-4756-3p	CLIP-seq
MIRT2155849	hsa-miR-4768-5p	CLIP-seq
MIRT2375555	hsa-miR-496	CLIP-seq
MIRT1516461	hsa-miR-5095	CLIP-seq
MIRT2155850	hsa-miR-512-3p	CLIP-seq
MIRT2155851	hsa-miR-519d	CLIP-seq
MIRT2155852	hsa-miR-520a-3p	CLIP-seq
MIRT2155853	hsa-miR-520b	CLIP-seq
MIRT2155854	hsa-miR-520c-3p	CLIP-seq
MIRT2155855	hsa-miR-520d-3p	CLIP-seq
MIRT2155856	hsa-miR-520e	CLIP-seq
MIRT2155857	hsa-miR-520g	CLIP-seq
MIRT2155858	hsa-miR-520h	CLIP-seq
MIRT2375556	hsa-miR-543	CLIP-seq
MIRT1516462	hsa-miR-552	CLIP-seq
MIRT2375557	hsa-miR-556-5p	CLIP-seq
MIRT2155859	hsa-miR-599	CLIP-seq
MIRT1516464	hsa-miR-600	CLIP-seq
MIRT2375558	hsa-miR-662	CLIP-seq
MIRT2155860	hsa-miR-93	CLIP-seq
MIRT2375559	hsa-miR-942	CLIP-seq
MIRT2375534	hsa-miR-1236	CLIP-seq
MIRT2375535	hsa-miR-1260	CLIP-seq
MIRT2375536	hsa-miR-1260b	CLIP-seq
MIRT1516438	hsa-miR-181a	CLIP-seq
MIRT1516439	hsa-miR-181b	CLIP-seq
MIRT1516440	hsa-miR-181c	CLIP-seq
MIRT1516441	hsa-miR-181d	CLIP-seq
MIRT2375540	hsa-miR-188-3p	CLIP-seq
MIRT2667900	hsa-miR-208a	CLIP-seq
MIRT2667901	hsa-miR-208b	CLIP-seq
MIRT2375543	hsa-miR-3156-3p	CLIP-seq
MIRT1516446	hsa-miR-3158-3p	CLIP-seq
MIRT1516447	hsa-miR-3159	CLIP-seq
MIRT2155841	hsa-miR-3160-5p	CLIP-seq
MIRT2375544	hsa-miR-3174	CLIP-seq
MIRT1516451	hsa-miR-376a	CLIP-seq
MIRT1516452	hsa-miR-376b	CLIP-seq
MIRT1516456	hsa-miR-4262	CLIP-seq
MIRT2375548	hsa-miR-4276	CLIP-seq
MIRT2667902	hsa-miR-4432	CLIP-seq
MIRT1516457	hsa-miR-4446-3p	CLIP-seq
MIRT2667903	hsa-miR-4477a	CLIP-seq
MIRT2375553	hsa-miR-4729	CLIP-seq
MIRT2155848	hsa-miR-4753-3p	CLIP-seq
MIRT2667904	hsa-miR-485-3p	CLIP-seq
MIRT2667905	hsa-miR-499-5p	CLIP-seq
MIRT2375558	hsa-miR-662	CLIP-seq
MIRT2375559	hsa-miR-942	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	7649249
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 21516116, 25416956, 31403225, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 604078
• HGNC: 12920
• e!Ensembl: ENSG00000196646

Protein

• UniProt ID: P52737
• Protein name: Zinc finger protein 136
• Protein function: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	336 → 358	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	476 → 498	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	252 → 274	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	420 → 442	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	196 → 218	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	308 → 330	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	392 → 414	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	168 → 190	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	3 → 44	KRAB box	Family
  PF13894	zf-C2H2_4	364 → 387		Domain
  PF13912	zf-C2H2_6	448 → 470		Domain
  PF13912	zf-C2H2_6	224 → 248		Domain

• Tissue specificity: TISSUE SPECIFICITY: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
• Sequence:

  MDSVAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIGKKWKDQNIKDHYKHRG
  RNLRSHMLERLYQTKDGSQRGGIFSQFANQNLSKKIPGVKLCESIVYGEVSMGQSSLNRH
  IKDHSGHEPKEYQEYGEKPDTRNQCWKPFSSHHSFRTHEIIHTGEKLYDCKECGKTFFSL
  KRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGEKPYECQECGKAFTCITSVR
  RHMIKHTGDGPYKCKVCGKPFHSLSSFQVHERIHTGEKPFKCKQCGKAFSCSPTLRIHER
  THTGEKPYECKQCGKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTG
  EKPYECKECGEAFSCIPSMRRHMIKHTGEGPYKCKVCGKPFHSLSPFRIHERTHTGEKPY
  VCKHCGKAFVSSTSIRIHERTHTGEKPYECKQCGKAFSYLNSFRTHEMIHTGEKPFECKR
  CGKAFRSSSSFRLHERTHTGQKPYHCKECGKAYSCRASFQRHMLTHAEDGPPYKCMWESL
  

• Sequence length: 540

Pathways

Reactome Pathway:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Prostate cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Aggressive Periodontitis	Aggressive Periodontitis	BEFREE	31373687		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	37033211	Associate	★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	37033211	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	33091877	Associate	★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	Pubtator	37466550	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ZNF136.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF136.