ZNF135 (zinc finger protein 135)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7694
• Gene name: Zinc finger protein 135
• Gene symbol: ZNF135
• Synonyms (NCBI Gene): ZNF61, ZNF78L1, pHZ-17, pT3
• Chromosome: 19
• Chromosome location: 19q13.43

miRNA Show/Hide all (111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018462	hsa-miR-335-5p	Microarray	18185580
MIRT625470	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625469	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT625468	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625467	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT625466	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625465	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT527311	hsa-miR-224-5p	PAR-CLIP	22012620
MIRT527310	hsa-miR-4438	PAR-CLIP	22012620
MIRT527309	hsa-miR-6504-3p	PAR-CLIP	22012620
MIRT527308	hsa-miR-5095	PAR-CLIP	22012620
MIRT527307	hsa-miR-7151-3p	PAR-CLIP	22012620
MIRT625470	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625469	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT625468	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625467	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT625466	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625465	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT527311	hsa-miR-224-5p	PAR-CLIP	22012620
MIRT527310	hsa-miR-4438	PAR-CLIP	22012620
MIRT527309	hsa-miR-6504-3p	PAR-CLIP	22012620
MIRT527308	hsa-miR-5095	PAR-CLIP	22012620
MIRT527307	hsa-miR-7151-3p	PAR-CLIP	22012620
MIRT1516422	hsa-miR-1297	CLIP-seq
MIRT1516423	hsa-miR-224	CLIP-seq
MIRT1516424	hsa-miR-24	CLIP-seq
MIRT1516425	hsa-miR-26a	CLIP-seq
MIRT1516426	hsa-miR-26b	CLIP-seq
MIRT1516427	hsa-miR-3155	CLIP-seq
MIRT1516428	hsa-miR-3155b	CLIP-seq
MIRT1516429	hsa-miR-4284	CLIP-seq
MIRT1516430	hsa-miR-4465	CLIP-seq
MIRT1516431	hsa-miR-4667-3p	CLIP-seq
MIRT1516432	hsa-miR-4717-3p	CLIP-seq
MIRT1516433	hsa-miR-484	CLIP-seq
MIRT1516434	hsa-miR-934	CLIP-seq
MIRT1516435	hsa-miR-154	CLIP-seq
MIRT1516436	hsa-miR-548u	CLIP-seq
MIRT2375492	hsa-miR-106a	CLIP-seq
MIRT2375493	hsa-miR-106b	CLIP-seq
MIRT2375494	hsa-miR-122	CLIP-seq
MIRT2375495	hsa-miR-1224-3p	CLIP-seq
MIRT2375496	hsa-miR-1260	CLIP-seq
MIRT2375497	hsa-miR-1260b	CLIP-seq
MIRT2375498	hsa-miR-1280	CLIP-seq
MIRT2375499	hsa-miR-130a	CLIP-seq
MIRT2375500	hsa-miR-130b	CLIP-seq
MIRT2375501	hsa-miR-150	CLIP-seq
MIRT2375502	hsa-miR-17	CLIP-seq
MIRT2375503	hsa-miR-20a	CLIP-seq
MIRT2375504	hsa-miR-20b	CLIP-seq
MIRT2375505	hsa-miR-301a	CLIP-seq
MIRT2375506	hsa-miR-301b	CLIP-seq
MIRT2375507	hsa-miR-302a	CLIP-seq
MIRT2375508	hsa-miR-302b	CLIP-seq
MIRT2375509	hsa-miR-302c	CLIP-seq
MIRT2375510	hsa-miR-302d	CLIP-seq
MIRT2375511	hsa-miR-302e	CLIP-seq
MIRT2375512	hsa-miR-3135b	CLIP-seq
MIRT2375513	hsa-miR-3652	CLIP-seq
MIRT2375514	hsa-miR-3666	CLIP-seq
MIRT2375515	hsa-miR-372	CLIP-seq
MIRT2375516	hsa-miR-373	CLIP-seq
MIRT2375517	hsa-miR-4295	CLIP-seq
MIRT2375518	hsa-miR-4423-5p	CLIP-seq
MIRT2375519	hsa-miR-4430	CLIP-seq
MIRT2375520	hsa-miR-454	CLIP-seq
MIRT2375521	hsa-miR-4731-5p	CLIP-seq
MIRT2375522	hsa-miR-4757-5p	CLIP-seq
MIRT2375523	hsa-miR-512-3p	CLIP-seq
MIRT2375524	hsa-miR-519d	CLIP-seq
MIRT2375525	hsa-miR-520a-3p	CLIP-seq
MIRT2375526	hsa-miR-520b	CLIP-seq
MIRT2375527	hsa-miR-520c-3p	CLIP-seq
MIRT2375528	hsa-miR-520d-3p	CLIP-seq
MIRT2375529	hsa-miR-520e	CLIP-seq
MIRT2375530	hsa-miR-520g	CLIP-seq
MIRT2375531	hsa-miR-520h	CLIP-seq
MIRT2375532	hsa-miR-532-3p	CLIP-seq
MIRT2375533	hsa-miR-93	CLIP-seq
MIRT2375494	hsa-miR-122	CLIP-seq
MIRT2375499	hsa-miR-130a	CLIP-seq
MIRT2375500	hsa-miR-130b	CLIP-seq
MIRT2375505	hsa-miR-301a	CLIP-seq
MIRT2375506	hsa-miR-301b	CLIP-seq
MIRT2375512	hsa-miR-3135b	CLIP-seq
MIRT2375513	hsa-miR-3652	CLIP-seq
MIRT2375514	hsa-miR-3666	CLIP-seq
MIRT2375517	hsa-miR-4295	CLIP-seq
MIRT2375518	hsa-miR-4423-5p	CLIP-seq
MIRT2375519	hsa-miR-4430	CLIP-seq
MIRT2375520	hsa-miR-454	CLIP-seq
MIRT2464055	hsa-miR-4639-3p	CLIP-seq
MIRT2464056	hsa-miR-4797-5p	CLIP-seq
MIRT2375494	hsa-miR-122	CLIP-seq
MIRT2695741	hsa-miR-128	CLIP-seq
MIRT2375499	hsa-miR-130a	CLIP-seq
MIRT2375500	hsa-miR-130b	CLIP-seq
MIRT2375505	hsa-miR-301a	CLIP-seq
MIRT2375506	hsa-miR-301b	CLIP-seq
MIRT2375512	hsa-miR-3135b	CLIP-seq
MIRT2375513	hsa-miR-3652	CLIP-seq
MIRT2375514	hsa-miR-3666	CLIP-seq
MIRT2695742	hsa-miR-4252	CLIP-seq
MIRT2375517	hsa-miR-4295	CLIP-seq
MIRT2375518	hsa-miR-4423-5p	CLIP-seq
MIRT2375519	hsa-miR-4430	CLIP-seq
MIRT2375520	hsa-miR-454	CLIP-seq
MIRT2464055	hsa-miR-4639-3p	CLIP-seq
MIRT2464056	hsa-miR-4797-5p	CLIP-seq
MIRT2695743	hsa-miR-587	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007010	Process	Cytoskeleton organization	IMP	21834987
GO:0008270	Function	Zinc ion binding	IEA
GO:0022603	Process	Regulation of anatomical structure morphogenesis	IEA
GO:0022604	Process	Regulation of cell morphogenesis	IMP	21834987
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 604077
• HGNC: 12919
• e!Ensembl: ENSG00000176293

Protein

• UniProt ID: P52742
• Protein name: Zinc finger protein 135 (Zinc finger protein 61) (Zinc finger protein 78-like 1)
• Protein function: Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	494 → 516	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	354 → 376	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	634 → 656	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	606 → 628	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	550 → 572	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	326 → 348	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	466 → 488	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	214 → 236	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	410 → 432	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	242 → 264	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	578 → 600	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	382 → 404	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	438 → 460	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	298 → 320	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	270 → 292	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	522 → 544	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	13 → 54	KRAB box	Family

• Sequence:

  MTPGVRVSTDPEQVTFEDVVVGFSQEEWGQLKPAQRTLYRDVMLDTFRLLVSVGHWLPKP
  NVISLLEQEAELWAVESRLPQGVYPDLETRPKVKLSVLKQGISEEISNSVILVERFLWDG
  LWYCRGEDTEGHWEWSCESLESLAVPVAFTPVKTPVLEQWQRNGFGENISLNPDLPHQPM
  TPERQSPHTWGTRGKREKPDLNVLQKTCVKEKPYKCQECGKAFSHSSALIEHHRTHTGER
  PYECHECLKGFRNSSALTKHQRIHTGEKPYKCTQCGRTFNQIAPLIQHQRTHTGEKPYEC
  SECGKSFSFRSSFSQHERTHTGEKPYECSECGKAFRQSIHLTQHLRIHTGEKPYQCGECG
  KAFSHSSSLTKHQRIHTGEKPYECHECGKAFTQITPLIQHQRTHTGEKPYECGECGKAFS
  QSTLLTEHRRIHTGEKPYGCNECGKTFSHSSSLSQHERTHTGEKPYECSQCGKAFRQSTH
  LTQHQRIHTGEKPYECNDCGKAFSHSSSLTKHQRIHTGEKPYECNQCGRAFSQLAPLIQH
  QRIHTGEKPYECNQCGRAFSQSSLLIEHQRIHTKEKPYGCNECGKSFSHSSSLSQHERTH
  TGEKPYECHDCGKSFRQSTHLTQHRRIHTGEKPYACRDCGKAFTHSSSLTKHQRTHTG

• Sequence length: 658

Pathways

Reactome Pathway:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Colon adenocarcinoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (6)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35202405	Associate	★☆☆☆☆ Found in Text Mining only
Congenital Hyperinsulinism	Congenital hyperinsulinism	Pubtator	32203961	Stimulate	★☆☆☆☆ Found in Text Mining only
Congenital Hyperinsulinism	Congenital hyperinsulinism	Pubtator	32203961	Associate	★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic fibrosis	Pubtator	2897786	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	19389243, 29516986	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	25914202	Inhibit	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ZNF135.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF135.