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Gene Gene information from NCBI Gene database.
Entrez ID 7559
Gene name Zinc finger protein 12
Gene symbol ZNF12
Synonyms (NCBI Gene)
GIOT-3HZF11KOX3ZNF325
Chromosome 7
Chromosome location 7p22.1
Summary This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional s
miRNA miRNA information provided by mirtarbase database.
1366 Show/Hide all (1366)
miRTarBase ID miRNA Experiments Reference
MIRT025182 hsa-miR-181a-5p Microarray 17612493
MIRT498886 hsa-miR-548n PAR-CLIP 20371350
MIRT104126 hsa-miR-548l PAR-CLIP 20371350
MIRT498885 hsa-miR-605-5p PAR-CLIP 20371350
MIRT498884 hsa-miR-5197-3p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
194536 12902 ENSG00000164631
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P17014
Protein name Zinc finger protein 12 (Gonadotropin-inducible ovary transcription repressor 3) (GIOT-3) (Zinc finger protein 325) (Zinc finger protein KOX3)
Protein function Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 381 → 403 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 577 → 599 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 437 → 459 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 297 → 319 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 633 → 655 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 353 → 375 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 465 → 487 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 521 → 543 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 409 → 431 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 661 → 683 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 269 → 291 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 325 → 347 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 493 → 515 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 549 → 571 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 605 → 627 Zinc finger, C2H2 type Domain
PF01352 KRAB 7 → 48 KRAB box Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed in various adult tissues and embryonic developmental stages (isoform 3). {ECO:0000269|PubMed:16806083}.
Sequence
MNKSLGPVSFKDVAVDFTQEEWQQLDPEQKITYRDVMLENYSNLVSVGYHIIKPDVISKL
EQGEEPWIVEGEFLLQSYPDEVWQTDDLIERIQEEENKPSRQTVFIETLIEERGNVPGKT
FDVETNPVPSRKIAYKNSLCDSCEKCLTSVSEYISSDGSYARMKADECSGCGKSLLHIKL
EKTHPGDQAYEFNQNGEPYTLNEESLYQKIRILEKPFEYIECQKAFQKDTVFVNHMEEKP
YKWNGSEIAFLQMSDLTVHQTSHMEMKPYECSECGKSFCKKSKFIIHQRTHTGEKPYECN
QCGKSFCQKGTLTVHQRTH
TGEKPYECNECGKNFYQKLHLIQHQRTHSGEKPYECSYCGK
SFCQKTHLTQHQRTH
SGERPYVCHDCGKTFSQKSALNDHQKIHTGVKLYKCSECGKCFCR
KSTLTTHLRTH
TGEKPYECNECGKFFSRLSYLTVHYRTHSGEKPYECNECGKTFYLNSAL
MRHQRVH
TGEKPYECNECGKLFSQLSYLTIHHRTHSGVKPYECSECGKTFYQNSALCRHR
RIH
KGEKPYECYICGKFFSQMSYLTIHHRIHSGEKPYECSECGKTFCQNSALNRHQRTHT
GEKAYECYECGKCFSQMSYLTIHHRIHSGEKPFECNECGKAFSRMSYLTVHYRTHSGEKP
YECTECGKKFYHKSAFNSHQRIHRRGNMNVIDVGRLL
Sequence length 697
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Generic Transcription Pathway