Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 79038
Gene name Zinc finger FYVE-type containing 21
Gene symbol ZFYVE21
Synonyms (NCBI Gene)
HCVP7TP1ZF21
Chromosome 14
Chromosome location 14q32.33
miRNA miRNA information provided by mirtarbase database.
556 Show/Hide all (556)
miRTarBase ID miRNA Experiments Reference
MIRT042353 hsa-miR-484 CLASH 23622248
MIRT069407 hsa-miR-142-5p HITS-CLIP 21572407
MIRT069415 hsa-miR-5590-3p HITS-CLIP 21572407
MIRT069411 hsa-miR-548n HITS-CLIP 21572407
MIRT069416 hsa-miR-548av-5p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
7 Show/Hide all (7)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 32296183, 32814053
GO:0005768 Component Endosome IEA
GO:0005925 Component Focal adhesion IEA
GO:0008270 Function Zinc ion binding IEA
GO:0031410 Component Cytoplasmic vesicle IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613504 20760 ENSG00000100711
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BQ24
Protein name Zinc finger FYVE domain-containing protein 21 (ZF21)
Protein function Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as we
PDB 2RRF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01363 FYVE 39 → 104 FYVE zinc finger Domain
PF16696 ZFYVE21_C 108 → 233 Zinc finger FYVE domain-containing protein 21 C-terminus Domain
Sequence
Sequence length 234
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Premature coronary artery atherosclerosis Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations