ZFY (zinc finger protein Y-linked)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7544
• Gene name: Zinc finger protein Y-linked
• Gene symbol: ZFY
• Synonyms (NCBI Gene): ZNF911
• Chromosome: Y
• Chromosome location: Yp11.2
• Summary: This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]

miRNA Show/Hide all (52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029024	hsa-miR-26b-5p	Microarray	19088304
MIRT1512200	hsa-miR-1305	CLIP-seq
MIRT1512201	hsa-miR-421	CLIP-seq
MIRT1512202	hsa-miR-4266	CLIP-seq
MIRT1512203	hsa-miR-4436b-5p	CLIP-seq
MIRT1512204	hsa-miR-4695-5p	CLIP-seq
MIRT1512205	hsa-miR-4779	CLIP-seq
MIRT1512206	hsa-miR-494	CLIP-seq
MIRT1512207	hsa-miR-581	CLIP-seq
MIRT1512208	hsa-miR-105	CLIP-seq
MIRT1512209	hsa-miR-1273e	CLIP-seq
MIRT1512200	hsa-miR-1305	CLIP-seq
MIRT1512210	hsa-miR-186	CLIP-seq
MIRT1512211	hsa-miR-3125	CLIP-seq
MIRT1512212	hsa-miR-3133	CLIP-seq
MIRT1512213	hsa-miR-3202	CLIP-seq
MIRT1512214	hsa-miR-338-5p	CLIP-seq
MIRT1512215	hsa-miR-3916	CLIP-seq
MIRT1512201	hsa-miR-421	CLIP-seq
MIRT1512202	hsa-miR-4266	CLIP-seq
MIRT1512216	hsa-miR-4427	CLIP-seq
MIRT1512203	hsa-miR-4436b-5p	CLIP-seq
MIRT1512217	hsa-miR-4475	CLIP-seq
MIRT1512218	hsa-miR-4476	CLIP-seq
MIRT1512219	hsa-miR-4666-3p	CLIP-seq
MIRT1512204	hsa-miR-4695-5p	CLIP-seq
MIRT1512220	hsa-miR-4699-3p	CLIP-seq
MIRT1512221	hsa-miR-4720-3p	CLIP-seq
MIRT1512222	hsa-miR-4738-3p	CLIP-seq
MIRT1512205	hsa-miR-4779	CLIP-seq
MIRT1512223	hsa-miR-4795-3p	CLIP-seq
MIRT1512224	hsa-miR-4797-5p	CLIP-seq
MIRT1512225	hsa-miR-4804-3p	CLIP-seq
MIRT1512206	hsa-miR-494	CLIP-seq
MIRT1512207	hsa-miR-581	CLIP-seq
MIRT1512226	hsa-miR-891b	CLIP-seq
MIRT2154251	hsa-miR-3922-5p	CLIP-seq
MIRT2154252	hsa-miR-3977	CLIP-seq
MIRT2154253	hsa-miR-4753-5p	CLIP-seq
MIRT2154254	hsa-miR-544	CLIP-seq
MIRT2374460	hsa-miR-3671	CLIP-seq
MIRT2374461	hsa-miR-371-5p	CLIP-seq
MIRT2374462	hsa-miR-371b-5p	CLIP-seq
MIRT2374463	hsa-miR-513c	CLIP-seq
MIRT2374464	hsa-miR-514b-5p	CLIP-seq
MIRT2441789	hsa-miR-154	CLIP-seq
MIRT2441790	hsa-miR-4782-5p	CLIP-seq
MIRT2667094	hsa-miR-1273g	CLIP-seq
MIRT2667095	hsa-miR-4282	CLIP-seq
MIRT2667096	hsa-miR-4639-5p	CLIP-seq
MIRT2667097	hsa-miR-4670-3p	CLIP-seq
MIRT2667098	hsa-miR-4735-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISS	32406922
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS	32406922
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	ISS	32406922
GO:0001541	Process	Ovarian follicle development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	26871637, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007281	Process	Germ cell development	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009566	Process	Fertilization	IEA
GO:0009791	Process	Post-embryonic development	IEA
GO:0035264	Process	Multicellular organism growth	IEA
GO:0043565	Function	Sequence-specific DNA binding	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS	32406922
GO:0046872	Function	Metal ion binding	IEA
GO:0048599	Process	Oocyte development	IEA
GO:0048872	Process	Homeostasis of number of cells	IEA
GO:0060746	Process	Parental behavior	IEA

Other IDs

• MIM: 490000
• HGNC: 12870
• e!Ensembl: ENSG00000067646

Protein

• UniProt ID: P08048
• Protein name: Zinc finger Y-chromosomal protein
• Protein function: Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.
• PDB: 1KLR , 1KLS , 1XRZ , 5ZNF , 7ZNF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	544 → 566	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	421 → 443	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	715 → 737	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	658 → 680	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	743 → 766	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	772 → 795	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	484 → 506	Zinc finger, C2H2 type	Domain
  PF04704	Zfx_Zfy_act	71 → 406	Zfx / Zfy transcription activation region	Family
  PF13909	zf-H2C2_5	572 → 597		Domain

• Sequence:

  MDEDEFELQPQEPNSFFDGIGADATHMDGDQIVVEIQEAVFVSNIVDSDITVHNFVPDDP
  DSVVIQDVVEDVVIEEDVQCSDILEEADVSENVIIPEQVLDSDVTEEVSLPHCTVPDDVL
  ASDITSTSMSMPEHVLTSESMHVCDIGHVEHMVHDSVVEAEIITDPLTSDIVSEEVLVAD
  CAPEAVIDASGISVDQQDNDKASCEDYLMISLDDAGKIEHDGSTGVTIDAESEMDPCKVD
  STCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVN
  DSQQEDEDLNVAEIADEVYMEVIVGEEDAAVAAAAAAVHEQQIDEDEMKTFVPIAWAAAY
  GNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKKRRPDSRQYQTAIIIGPDGHPLTV
  YPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCTDCDYTTNKKISLHNHLESHKLTSKA
  EKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSK
  NFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHIKTKHSKEMP
  FKCDICLLTFSDTKEVQQHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKC
  EMCEKGFHRPSELKKHVAVHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRC
  RKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKG
  FRRPSEKNQHIMRHHKEVGLP

• Sequence length: 801

Related Genes

No strongly related genes found yet for ZFY.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZFY.