ZFAND1 (zinc finger AN1-type containing 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 79752
• Gene name: Zinc finger AN1-type containing 1
• Gene symbol: ZFAND1
• Synonyms (NCBI Gene): -
• Chromosome: 8
• Chromosome location: 8q21.13

miRNA Show/Hide all (171)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021302	hsa-miR-125a-5p	Sequencing	20371350
MIRT690126	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT690125	hsa-miR-9-5p	HITS-CLIP	23313552
MIRT690124	hsa-miR-4670-3p	HITS-CLIP	23313552
MIRT690123	hsa-miR-1251-3p	HITS-CLIP	23313552
MIRT690122	hsa-miR-3622b-5p	HITS-CLIP	23313552
MIRT690121	hsa-miR-2052	HITS-CLIP	23313552
MIRT690120	hsa-miR-19a-5p	HITS-CLIP	23313552
MIRT690119	hsa-miR-19b-1-5p	HITS-CLIP	23313552
MIRT690118	hsa-miR-19b-2-5p	HITS-CLIP	23313552
MIRT690117	hsa-miR-579-3p	HITS-CLIP	23313552
MIRT690116	hsa-miR-664b-3p	HITS-CLIP	23313552
MIRT690115	hsa-miR-4642	HITS-CLIP	23313552
MIRT690114	hsa-miR-182-5p	HITS-CLIP	23313552
MIRT690113	hsa-miR-1271-5p	HITS-CLIP	23313552
MIRT690112	hsa-miR-96-5p	HITS-CLIP	23313552
MIRT690111	hsa-miR-6885-3p	HITS-CLIP	23313552
MIRT690126	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT690125	hsa-miR-9-5p	HITS-CLIP	23313552
MIRT690124	hsa-miR-4670-3p	HITS-CLIP	23313552
MIRT690123	hsa-miR-1251-3p	HITS-CLIP	23313552
MIRT690122	hsa-miR-3622b-5p	HITS-CLIP	23313552
MIRT690121	hsa-miR-2052	HITS-CLIP	23313552
MIRT690120	hsa-miR-19a-5p	HITS-CLIP	23313552
MIRT690119	hsa-miR-19b-1-5p	HITS-CLIP	23313552
MIRT690118	hsa-miR-19b-2-5p	HITS-CLIP	23313552
MIRT690117	hsa-miR-579-3p	HITS-CLIP	23313552
MIRT690116	hsa-miR-664b-3p	HITS-CLIP	23313552
MIRT690115	hsa-miR-4642	HITS-CLIP	23313552
MIRT690114	hsa-miR-182-5p	HITS-CLIP	23313552
MIRT690113	hsa-miR-1271-5p	HITS-CLIP	23313552
MIRT690112	hsa-miR-96-5p	HITS-CLIP	23313552
MIRT690111	hsa-miR-6885-3p	HITS-CLIP	23313552
MIRT1509403	hsa-miR-155	CLIP-seq
MIRT1509404	hsa-miR-25	CLIP-seq
MIRT1509405	hsa-miR-3121-3p	CLIP-seq
MIRT1509406	hsa-miR-32	CLIP-seq
MIRT1509407	hsa-miR-363	CLIP-seq
MIRT1509408	hsa-miR-3662	CLIP-seq
MIRT1509409	hsa-miR-367	CLIP-seq
MIRT1509410	hsa-miR-3936	CLIP-seq
MIRT1509411	hsa-miR-4501	CLIP-seq
MIRT1509412	hsa-miR-4504	CLIP-seq
MIRT1509413	hsa-miR-542-3p	CLIP-seq
MIRT1509414	hsa-miR-92a	CLIP-seq
MIRT1509415	hsa-miR-92b	CLIP-seq
MIRT1509416	hsa-miR-125b	CLIP-seq
MIRT1509417	hsa-miR-1322	CLIP-seq
MIRT1509418	hsa-miR-149	CLIP-seq
MIRT1509419	hsa-miR-3064-5p	CLIP-seq
MIRT1509420	hsa-miR-3120-3p	CLIP-seq
MIRT1509421	hsa-miR-3146	CLIP-seq
MIRT1509422	hsa-miR-3187-3p	CLIP-seq
MIRT1509423	hsa-miR-330-3p	CLIP-seq
MIRT1509424	hsa-miR-3651	CLIP-seq
MIRT1509425	hsa-miR-425	CLIP-seq
MIRT1509426	hsa-miR-4319	CLIP-seq
MIRT1509427	hsa-miR-4435	CLIP-seq
MIRT1509428	hsa-miR-4519	CLIP-seq
MIRT1509429	hsa-miR-4701-5p	CLIP-seq
MIRT1509430	hsa-miR-4708-3p	CLIP-seq
MIRT1509431	hsa-miR-4732-3p	CLIP-seq
MIRT1509432	hsa-miR-4794	CLIP-seq
MIRT1509433	hsa-miR-548s	CLIP-seq
MIRT1509434	hsa-miR-588	CLIP-seq
MIRT1509435	hsa-miR-597	CLIP-seq
MIRT1509436	hsa-miR-642b	CLIP-seq
MIRT1509437	hsa-miR-645	CLIP-seq
MIRT1509438	hsa-miR-670	CLIP-seq
MIRT1921108	hsa-miR-4289	CLIP-seq
MIRT1921108	hsa-miR-4289	CLIP-seq
MIRT2373715	hsa-miR-1245b-5p	CLIP-seq
MIRT2373716	hsa-miR-3142	CLIP-seq
MIRT2373717	hsa-miR-4279	CLIP-seq
MIRT2373718	hsa-miR-4724-5p	CLIP-seq
MIRT2373719	hsa-miR-4738-3p	CLIP-seq
MIRT2373720	hsa-miR-548c-3p	CLIP-seq
MIRT2666406	hsa-miR-1244	CLIP-seq
MIRT2666407	hsa-miR-1275	CLIP-seq
MIRT1509417	hsa-miR-1322	CLIP-seq
MIRT1509418	hsa-miR-149	CLIP-seq
MIRT2666408	hsa-miR-2681	CLIP-seq
MIRT2666409	hsa-miR-297	CLIP-seq
MIRT1509419	hsa-miR-3064-5p	CLIP-seq
MIRT2666410	hsa-miR-30a	CLIP-seq
MIRT2666411	hsa-miR-30b	CLIP-seq
MIRT2666412	hsa-miR-30c	CLIP-seq
MIRT2666413	hsa-miR-30d	CLIP-seq
MIRT2666414	hsa-miR-30e	CLIP-seq
MIRT1509420	hsa-miR-3120-3p	CLIP-seq
MIRT2666415	hsa-miR-3120-5p	CLIP-seq
MIRT1509405	hsa-miR-3121-3p	CLIP-seq
MIRT2666416	hsa-miR-3129-3p	CLIP-seq
MIRT2666417	hsa-miR-3144-3p	CLIP-seq
MIRT1509421	hsa-miR-3146	CLIP-seq
MIRT1509422	hsa-miR-3187-3p	CLIP-seq
MIRT1509423	hsa-miR-330-3p	CLIP-seq
MIRT2666418	hsa-miR-338-5p	CLIP-seq
MIRT2666419	hsa-miR-3613-3p	CLIP-seq
MIRT2666420	hsa-miR-361-3p	CLIP-seq
MIRT2666421	hsa-miR-3658	CLIP-seq
MIRT2666422	hsa-miR-3913-3p	CLIP-seq
MIRT2666423	hsa-miR-3924	CLIP-seq
MIRT2666424	hsa-miR-421	CLIP-seq
MIRT2666425	hsa-miR-4260	CLIP-seq
MIRT1921108	hsa-miR-4289	CLIP-seq
MIRT2666426	hsa-miR-4422	CLIP-seq
MIRT1509427	hsa-miR-4435	CLIP-seq
MIRT1509428	hsa-miR-4519	CLIP-seq
MIRT2666427	hsa-miR-4636	CLIP-seq
MIRT2666428	hsa-miR-4639-5p	CLIP-seq
MIRT2666429	hsa-miR-4665-5p	CLIP-seq
MIRT1509429	hsa-miR-4701-5p	CLIP-seq
MIRT2666430	hsa-miR-4704-5p	CLIP-seq
MIRT1509430	hsa-miR-4708-3p	CLIP-seq
MIRT2666431	hsa-miR-4709-5p	CLIP-seq
MIRT2666432	hsa-miR-4720-3p	CLIP-seq
MIRT2373718	hsa-miR-4724-5p	CLIP-seq
MIRT2666433	hsa-miR-4733-3p	CLIP-seq
MIRT2373719	hsa-miR-4738-3p	CLIP-seq
MIRT2666434	hsa-miR-4753-3p	CLIP-seq
MIRT2666435	hsa-miR-4768-5p	CLIP-seq
MIRT2666436	hsa-miR-4773	CLIP-seq
MIRT2666437	hsa-miR-4778-5p	CLIP-seq
MIRT1509432	hsa-miR-4794	CLIP-seq
MIRT2666438	hsa-miR-4796-5p	CLIP-seq
MIRT2666439	hsa-miR-4799-5p	CLIP-seq
MIRT2666440	hsa-miR-4804-3p	CLIP-seq
MIRT2666441	hsa-miR-489	CLIP-seq
MIRT1509433	hsa-miR-548s	CLIP-seq
MIRT2666442	hsa-miR-567	CLIP-seq
MIRT2666443	hsa-miR-570	CLIP-seq
MIRT2666444	hsa-miR-587	CLIP-seq
MIRT1509434	hsa-miR-588	CLIP-seq
MIRT1509435	hsa-miR-597	CLIP-seq
MIRT1509436	hsa-miR-642b	CLIP-seq
MIRT1509437	hsa-miR-645	CLIP-seq
MIRT2666445	hsa-miR-668	CLIP-seq
MIRT2666446	hsa-miR-875-5p	CLIP-seq
MIRT1509417	hsa-miR-1322	CLIP-seq
MIRT1509418	hsa-miR-149	CLIP-seq
MIRT1509419	hsa-miR-3064-5p	CLIP-seq
MIRT1509420	hsa-miR-3120-3p	CLIP-seq
MIRT2666416	hsa-miR-3129-3p	CLIP-seq
MIRT1509421	hsa-miR-3146	CLIP-seq
MIRT1509422	hsa-miR-3187-3p	CLIP-seq
MIRT1509423	hsa-miR-330-3p	CLIP-seq
MIRT2666420	hsa-miR-361-3p	CLIP-seq
MIRT2666421	hsa-miR-3658	CLIP-seq
MIRT2666422	hsa-miR-3913-3p	CLIP-seq
MIRT2666424	hsa-miR-421	CLIP-seq
MIRT2666426	hsa-miR-4422	CLIP-seq
MIRT1509427	hsa-miR-4435	CLIP-seq
MIRT1509428	hsa-miR-4519	CLIP-seq
MIRT2666428	hsa-miR-4639-5p	CLIP-seq
MIRT1509429	hsa-miR-4701-5p	CLIP-seq
MIRT1509430	hsa-miR-4708-3p	CLIP-seq
MIRT2666431	hsa-miR-4709-5p	CLIP-seq
MIRT2666432	hsa-miR-4720-3p	CLIP-seq
MIRT2666433	hsa-miR-4733-3p	CLIP-seq
MIRT2666434	hsa-miR-4753-3p	CLIP-seq
MIRT2666435	hsa-miR-4768-5p	CLIP-seq
MIRT1509432	hsa-miR-4794	CLIP-seq
MIRT2666440	hsa-miR-4804-3p	CLIP-seq
MIRT2666441	hsa-miR-489	CLIP-seq
MIRT1509433	hsa-miR-548s	CLIP-seq
MIRT1509434	hsa-miR-588	CLIP-seq
MIRT1509435	hsa-miR-597	CLIP-seq
MIRT1509436	hsa-miR-642b	CLIP-seq
MIRT1509437	hsa-miR-645	CLIP-seq
MIRT2666445	hsa-miR-668	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	29804830
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010494	Component	Cytoplasmic stress granule	IBA
GO:0010494	Component	Cytoplasmic stress granule	IDA	29804830
GO:0010494	Component	Cytoplasmic stress granule	IEA
GO:0034599	Process	Cellular response to oxidative stress	IMP	29804830
GO:0034605	Process	Cellular response to heat	IMP	29804830
GO:0035617	Process	Stress granule disassembly	IBA
GO:0035617	Process	Stress granule disassembly	IEA
GO:0035617	Process	Stress granule disassembly	IMP	29804830
GO:0046872	Function	Metal ion binding	IEA
GO:0070628	Function	Proteasome binding	IDA	29804830
GO:0070628	Function	Proteasome binding	IEA
GO:0071470	Process	Cellular response to osmotic stress	IMP	29804830
GO:0090316	Process	Positive regulation of intracellular protein transport	IMP	29804830
GO:1903843	Process	Cellular response to arsenite ion	IEA
GO:1903843	Process	Cellular response to arsenite ion	IMP	29804830

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8TCF1
• Protein name: AN1-type zinc finger protein 1 (Zinc finger AN1-type-containing protein 1)
• Protein function: Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exog
• PDB: 7Y39 , 7Y7L , 7YAB , 8HW9 , 8XE8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01428	zf-AN1	10 → 48	AN1-like Zinc finger	Family
  PF01428	zf-AN1	64 → 102	AN1-like Zinc finger	Family

• Sequence:

  MAELDIGQHCQVEHCRQRDFLPFVCDDCSGIFCLEHRSRESHGCPEVTVINERLKTDQHT
  SYPCSFKDCAERELVAVICPYCEKNFCLRHRHQSDHECEKLEIPKPRMAATQKLVKDIID
  SKTGETASKRWKGAKNSETAAKVALMKLKMHADGDKSLPQTERIYFQVFLPKGSKEKSKP
  MFFCHRWSIGKAIDFAASLARLKNDNNKFTAKKLRLCHITSGEALPLDHTLETWIAKEDC
  PLYNGGNIILEYLNDEEQFCKNVESYLE

• Sequence length: 268

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Thymoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE AND FRONTOTEMPORAL DEMENTIA	Inclusion Body Myopathy With Paget Disease And Frontotemporal Dementia	BEFREE	29804830		★☆☆☆☆ Found in Text Mining only
Liver Neoplasms	Liver neoplasm	Pubtator	29804830	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	29804830	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ZFAND1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZFAND1.