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Gene Gene information from NCBI Gene database.
Entrez ID 10444
Gene name Zyg-11 related cell cycle regulator
Gene symbol ZER1
Synonyms (NCBI Gene)
C9orf60ZYGZYG11BL
Chromosome 9
Chromosome location 9q34.11
Summary This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]
miRNA miRNA information provided by mirtarbase database.
454 Show/Hide all (454)
miRTarBase ID miRNA Experiments Reference
MIRT017191 hsa-miR-335-5p Microarray 18185580
MIRT031202 hsa-miR-19b-3p Sequencing 20371350
MIRT052074 hsa-let-7b-5p CLASH 23622248
MIRT043566 hsa-miR-331-3p CLASH 23622248
MIRT040068 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 33961781
GO:0006515 Process Protein quality control for misfolded or incompletely synthesized proteins IMP 31273098
GO:0031462 Component Cul2-RING ubiquitin ligase complex IBA
GO:0031462 Component Cul2-RING ubiquitin ligase complex IDA 17304241, 31273098
GO:0032436 Process Positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 31273098
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617764 30960 ENSG00000160445
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7Z7L7
Protein name Protein zer-1 homolog (Hzyg) (Zyg-11 homolog B-like protein) (Zyg11b-like protein)
Protein function Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC (PubMed:17304241, PubMed:31273098). Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of su
PDB 7EP3 , 7EP4 , 7EP5 , 7XYS , 7XYT , 7XYU
Family and domains
Tissue specificity TISSUE SPECIFICITY: Expressed in testis, spermatocytes and spermatids (at protein level). Expressed in spermatocytes, spermatids, prostate, skeletal muscle, ovary, small intestine, heart, brain and pancreas. {ECO:0000269|PubMed:11719588}.
Sequence
MASDTPESLMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPSEICDRLVNEYVELVNA
ACNFEPHESFFSLFSDPRSTRLTRIHLREDLVQDQDLEAIRKQDLVELYLTNCEKLSAKS
LQTLRSFSHTLVSLSLFGCTNIFYEEENPGGCEDEYLVNPTCQVLVKDFTFEGFSRLRFL
NLGRMIDWVPVESLLRPLNSLAALDLSGIQTSDAAFLTQWKDSLVSLVLYNMDLSDDHIR
VIVQLHKLRHLDISRDRLSSYYKFKLTREVLSLFVQKLGNLMSLDISGHMILENCSISKM
EEEAGQTSIEPSKSSIIPFRALKRPLQFLGLFENSLCRLTHIPAYKVSGDKNEEQVLNAI
EAYTEHRPEITSRAINLLFDIARIERCNQLLRALKLVITALKCHKYDRNIQVTGSAALFY
LTNSEYRSEQSVKLRRQVIQVVLNGMESYQEVTVQRNCCLTLCNFSIPEELEFQYRRVNE
LLLSILNPTRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTC
DQVMEFSWSALWNITDETPDNCEMFLNFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAE
VKELRPQLMTSQFISVFSNLLESKADGIEVSYNACGVLSHIMFDGPEAWGVCEPQREEVE
ERMWAAIQSWDINSRRNINYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCPL
LIKEGGMPLLRDIIKMATARQETKEMARKVIEHCSNFKEENMDTSR
Sequence length 766
Interactions View interactions