ZER1 (zyg-11 related cell cycle regulator)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 10444 |
| Gene name | Zyg-11 related cell cycle regulator |
| Gene symbol | ZER1 |
| Synonyms (NCBI Gene) |
C9orf60ZYGZYG11BL
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| Chromosome | 9 |
| Chromosome location | 9q34.11 |
| Summary | This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012] |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q7Z7L7 |
| Protein name | Protein zer-1 homolog (Hzyg) (Zyg-11 homolog B-like protein) (Zyg11b-like protein) |
| Protein function | Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC (PubMed:17304241, PubMed:31273098). Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of su |
| PDB | 7EP3 , 7EP4 , 7EP5 , 7XYS , 7XYT , 7XYU |
| Family and domains | |
| Tissue specificity | TISSUE SPECIFICITY: Expressed in testis, spermatocytes and spermatids (at protein level). Expressed in spermatocytes, spermatids, prostate, skeletal muscle, ovary, small intestine, heart, brain and pancreas. {ECO:0000269|PubMed:11719588}. |
| Sequence |
MASDTPESLMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPSEICDRLVNEYVELVNA |
| Sequence length | 766 |
| Interactions | View interactions |
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Related Genes
Genes most often co-reported with ZER1 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to ZER1 (see Related Genes above), that are NOT already directly curated for ZER1 itself -- a lead worth checking, not a confirmed association.
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