ZDHHC6 (zDHHC palmitoyltransferase 6)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 64429
• Gene name: ZDHHC palmitoyltransferase 6
• Gene symbol: ZDHHC6
• Synonyms (NCBI Gene): DHHC-6, DHHC6, ZNF376
• Chromosome: 10
• Chromosome location: 10q25.2

miRNA Show/Hide all (199)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045294	hsa-miR-186-5p	CLASH	23622248
MIRT038979	hsa-miR-19b-1-5p	CLASH	23622248
MIRT456201	hsa-miR-4668-3p	PAR-CLIP	23592263
MIRT456200	hsa-miR-648	PAR-CLIP	23592263
MIRT456199	hsa-miR-4686	PAR-CLIP	23592263
MIRT456198	hsa-miR-759	PAR-CLIP	23592263
MIRT456197	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT456196	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT456195	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT456194	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT456193	hsa-miR-221-5p	PAR-CLIP	23592263
MIRT456192	hsa-miR-8073	PAR-CLIP	23592263
MIRT456191	hsa-miR-3158-5p	PAR-CLIP	23592263
MIRT456190	hsa-miR-1184	PAR-CLIP	23592263
MIRT456189	hsa-miR-1205	PAR-CLIP	23592263
MIRT456188	hsa-miR-17-3p	PAR-CLIP	23592263
MIRT456187	hsa-miR-3128	PAR-CLIP	23592263
MIRT456186	hsa-miR-574-5p	PAR-CLIP	23592263
MIRT456185	hsa-miR-3665	PAR-CLIP	23592263
MIRT456184	hsa-miR-657	PAR-CLIP	23592263
MIRT456183	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT456182	hsa-miR-31-5p	PAR-CLIP	23592263
MIRT456181	hsa-miR-6809-5p	PAR-CLIP	23592263
MIRT456180	hsa-miR-4471	PAR-CLIP	23592263
MIRT456179	hsa-miR-8059	PAR-CLIP	23592263
MIRT456178	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT456177	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT456176	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT456175	hsa-miR-4710	PAR-CLIP	23592263
MIRT456174	hsa-miR-198	PAR-CLIP	23592263
MIRT456173	hsa-miR-1294	PAR-CLIP	23592263
MIRT456172	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT456171	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT456170	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT456169	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT456168	hsa-miR-155-3p	PAR-CLIP	23592263
MIRT456201	hsa-miR-4668-3p	PAR-CLIP	23592263
MIRT456200	hsa-miR-648	PAR-CLIP	23592263
MIRT456199	hsa-miR-4686	PAR-CLIP	23592263
MIRT456198	hsa-miR-759	PAR-CLIP	23592263
MIRT456197	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT456196	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT456195	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT456194	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT456193	hsa-miR-221-5p	PAR-CLIP	23592263
MIRT456192	hsa-miR-8073	PAR-CLIP	23592263
MIRT456191	hsa-miR-3158-5p	PAR-CLIP	23592263
MIRT456190	hsa-miR-1184	PAR-CLIP	23592263
MIRT456189	hsa-miR-1205	PAR-CLIP	23592263
MIRT456188	hsa-miR-17-3p	PAR-CLIP	23592263
MIRT456187	hsa-miR-3128	PAR-CLIP	23592263
MIRT456186	hsa-miR-574-5p	PAR-CLIP	23592263
MIRT456185	hsa-miR-3665	PAR-CLIP	23592263
MIRT456184	hsa-miR-657	PAR-CLIP	23592263
MIRT456183	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT456182	hsa-miR-31-5p	PAR-CLIP	23592263
MIRT456181	hsa-miR-6809-5p	PAR-CLIP	23592263
MIRT456180	hsa-miR-4471	PAR-CLIP	23592263
MIRT456179	hsa-miR-8059	PAR-CLIP	23592263
MIRT456178	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT456177	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT456176	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT456175	hsa-miR-4710	PAR-CLIP	23592263
MIRT456174	hsa-miR-198	PAR-CLIP	23592263
MIRT456173	hsa-miR-1294	PAR-CLIP	23592263
MIRT456172	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT456171	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT456170	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT456169	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT456168	hsa-miR-155-3p	PAR-CLIP	23592263
MIRT1508881	hsa-miR-1224-5p	CLIP-seq
MIRT1508882	hsa-miR-1297	CLIP-seq
MIRT1508883	hsa-miR-1304	CLIP-seq
MIRT1508884	hsa-miR-1305	CLIP-seq
MIRT1508885	hsa-miR-135a	CLIP-seq
MIRT1508886	hsa-miR-135b	CLIP-seq
MIRT1508887	hsa-miR-136	CLIP-seq
MIRT1508888	hsa-miR-153	CLIP-seq
MIRT1508889	hsa-miR-154	CLIP-seq
MIRT1508890	hsa-miR-183	CLIP-seq
MIRT1508891	hsa-miR-2681	CLIP-seq
MIRT1508892	hsa-miR-26a	CLIP-seq
MIRT1508893	hsa-miR-26b	CLIP-seq
MIRT1508894	hsa-miR-298	CLIP-seq
MIRT1508895	hsa-miR-3133	CLIP-seq
MIRT1508896	hsa-miR-3200-5p	CLIP-seq
MIRT1508897	hsa-miR-3915	CLIP-seq
MIRT1508898	hsa-miR-3928	CLIP-seq
MIRT1508899	hsa-miR-4317	CLIP-seq
MIRT1508900	hsa-miR-4436b-3p	CLIP-seq
MIRT1508901	hsa-miR-4465	CLIP-seq
MIRT1508902	hsa-miR-448	CLIP-seq
MIRT1508903	hsa-miR-4503	CLIP-seq
MIRT1508904	hsa-miR-4517	CLIP-seq
MIRT1508905	hsa-miR-4649-3p	CLIP-seq
MIRT1508906	hsa-miR-4689	CLIP-seq
MIRT1508907	hsa-miR-4698	CLIP-seq
MIRT1508908	hsa-miR-4724-5p	CLIP-seq
MIRT1508909	hsa-miR-4761-3p	CLIP-seq
MIRT1508910	hsa-miR-4771	CLIP-seq
MIRT1508911	hsa-miR-4775	CLIP-seq
MIRT1508912	hsa-miR-495	CLIP-seq
MIRT1508913	hsa-miR-498	CLIP-seq
MIRT1508914	hsa-miR-499a-5p	CLIP-seq
MIRT1508915	hsa-miR-515-5p	CLIP-seq
MIRT1508916	hsa-miR-522	CLIP-seq
MIRT1508917	hsa-miR-590-3p	CLIP-seq
MIRT1508918	hsa-miR-607	CLIP-seq
MIRT1508888	hsa-miR-153	CLIP-seq
MIRT2153274	hsa-miR-31	CLIP-seq
MIRT2153275	hsa-miR-3126-5p	CLIP-seq
MIRT1508895	hsa-miR-3133	CLIP-seq
MIRT2153276	hsa-miR-4311	CLIP-seq
MIRT1508899	hsa-miR-4317	CLIP-seq
MIRT2153277	hsa-miR-4419a	CLIP-seq
MIRT1508902	hsa-miR-448	CLIP-seq
MIRT2153278	hsa-miR-4510	CLIP-seq
MIRT1508904	hsa-miR-4517	CLIP-seq
MIRT2153279	hsa-miR-4668-5p	CLIP-seq
MIRT2153280	hsa-miR-625	CLIP-seq
MIRT2373558	hsa-miR-148a	CLIP-seq
MIRT2373559	hsa-miR-148b	CLIP-seq
MIRT2373560	hsa-miR-152	CLIP-seq
MIRT1508890	hsa-miR-183	CLIP-seq
MIRT1508900	hsa-miR-4436b-3p	CLIP-seq
MIRT1508909	hsa-miR-4761-3p	CLIP-seq
MIRT1508881	hsa-miR-1224-5p	CLIP-seq
MIRT1508882	hsa-miR-1297	CLIP-seq
MIRT1508883	hsa-miR-1304	CLIP-seq
MIRT1508884	hsa-miR-1305	CLIP-seq
MIRT2666265	hsa-miR-140-3p	CLIP-seq
MIRT1508888	hsa-miR-153	CLIP-seq
MIRT1508892	hsa-miR-26a	CLIP-seq
MIRT1508893	hsa-miR-26b	CLIP-seq
MIRT2153274	hsa-miR-31	CLIP-seq
MIRT2153275	hsa-miR-3126-5p	CLIP-seq
MIRT1508895	hsa-miR-3133	CLIP-seq
MIRT2666266	hsa-miR-3168	CLIP-seq
MIRT1508897	hsa-miR-3915	CLIP-seq
MIRT1508898	hsa-miR-3928	CLIP-seq
MIRT2666267	hsa-miR-4268	CLIP-seq
MIRT2153276	hsa-miR-4311	CLIP-seq
MIRT1508899	hsa-miR-4317	CLIP-seq
MIRT2153277	hsa-miR-4419a	CLIP-seq
MIRT1508900	hsa-miR-4436b-3p	CLIP-seq
MIRT2666268	hsa-miR-4448	CLIP-seq
MIRT1508901	hsa-miR-4465	CLIP-seq
MIRT1508902	hsa-miR-448	CLIP-seq
MIRT1508903	hsa-miR-4503	CLIP-seq
MIRT2153278	hsa-miR-4510	CLIP-seq
MIRT1508904	hsa-miR-4517	CLIP-seq
MIRT2153279	hsa-miR-4668-5p	CLIP-seq
MIRT1508906	hsa-miR-4689	CLIP-seq
MIRT1508909	hsa-miR-4761-3p	CLIP-seq
MIRT1508910	hsa-miR-4771	CLIP-seq
MIRT1508911	hsa-miR-4775	CLIP-seq
MIRT2666269	hsa-miR-487a	CLIP-seq
MIRT1508913	hsa-miR-498	CLIP-seq
MIRT1508914	hsa-miR-499a-5p	CLIP-seq
MIRT1508917	hsa-miR-590-3p	CLIP-seq
MIRT2153280	hsa-miR-625	CLIP-seq
MIRT1508881	hsa-miR-1224-5p	CLIP-seq
MIRT1508882	hsa-miR-1297	CLIP-seq
MIRT1508883	hsa-miR-1304	CLIP-seq
MIRT1508884	hsa-miR-1305	CLIP-seq
MIRT2666265	hsa-miR-140-3p	CLIP-seq
MIRT2373558	hsa-miR-148a	CLIP-seq
MIRT2373559	hsa-miR-148b	CLIP-seq
MIRT2373560	hsa-miR-152	CLIP-seq
MIRT1508888	hsa-miR-153	CLIP-seq
MIRT1508892	hsa-miR-26a	CLIP-seq
MIRT1508893	hsa-miR-26b	CLIP-seq
MIRT2153274	hsa-miR-31	CLIP-seq
MIRT2153275	hsa-miR-3126-5p	CLIP-seq
MIRT1508895	hsa-miR-3133	CLIP-seq
MIRT2666266	hsa-miR-3168	CLIP-seq
MIRT1508897	hsa-miR-3915	CLIP-seq
MIRT1508898	hsa-miR-3928	CLIP-seq
MIRT2666267	hsa-miR-4268	CLIP-seq
MIRT2153276	hsa-miR-4311	CLIP-seq
MIRT1508899	hsa-miR-4317	CLIP-seq
MIRT2153277	hsa-miR-4419a	CLIP-seq
MIRT1508900	hsa-miR-4436b-3p	CLIP-seq
MIRT2666268	hsa-miR-4448	CLIP-seq
MIRT1508901	hsa-miR-4465	CLIP-seq
MIRT1508902	hsa-miR-448	CLIP-seq
MIRT1508903	hsa-miR-4503	CLIP-seq
MIRT2153278	hsa-miR-4510	CLIP-seq
MIRT1508904	hsa-miR-4517	CLIP-seq
MIRT2153279	hsa-miR-4668-5p	CLIP-seq
MIRT1508906	hsa-miR-4689	CLIP-seq
MIRT1508909	hsa-miR-4761-3p	CLIP-seq
MIRT1508910	hsa-miR-4771	CLIP-seq
MIRT1508911	hsa-miR-4775	CLIP-seq
MIRT2666269	hsa-miR-487a	CLIP-seq
MIRT1508913	hsa-miR-498	CLIP-seq
MIRT1508914	hsa-miR-499a-5p	CLIP-seq
MIRT1508917	hsa-miR-590-3p	CLIP-seq
MIRT2153280	hsa-miR-625	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22728137, 25368151, 28826475
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	16647879, 21926431, 25368151, 28826475
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0006612	Process	Protein targeting to membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016409	Function	Palmitoyltransferase activity	IDA	22728137, 23034182, 28826475
GO:0016409	Function	Palmitoyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	IBA
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IDA	25368151
GO:0035556	Process	Intracellular signal transduction	IMP	26214738
GO:0140439	Function	Protein-cysteine S-stearoyltransferase activity	IEA
GO:0140439	Function	Protein-cysteine S-stearoyltransferase activity	IMP	26214738

Other IDs

• MIM: 618715
• HGNC: 19160
• e!Ensembl: ENSG00000023041

Protein

• UniProt ID: Q9H6R6
• Protein name: Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Stearoyltransferase ZDHHC6) (EC 2.3.1.-) (Transmembrane protein H4) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376)
• Protein function: Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475). Palmitoylates calnexin (CALX), which is required fo
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01529	DHHC	94 → 244	DHHC palmitoyltransferase	Family
  PF07653	SH3_2	317 → 396	Variant SH3 domain	Domain

• Sequence:

  MGTFCSVIKFENLQELKRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIM
  LINWTVMILYNYFNAMFVGPGFVPLGWKPEISQDTMYLQYCKVCQAYKAPRSHHCRKCNR
  CVMKMDHHCPWINNCCGYQNHASFTLFLLLAPLGCIHAAFIFVMTMYTQLYHRLSFGWNT
  VKIDMSAARRDPLPIVPFGLAAFATTLFALGLALGTTIAVGMLFFIQMKIILRNKTSIES
  WIEEKAKDRIQYYQLDEVFVFPYDMGSRWRNFKQVFTWSGVPEGDGLEWPVREGCHQYSL
  TIEQLKQKADKRVRSVRYKVIEDYSGACCPLNKGIKTFFTSPCTEEPRIQLQKGEFILAT
  RGLRYWLYGDKILDDSFIEGVSRIRGWFPRKCVEKCPCDAETDQAPEGEKKNR

• Sequence length: 413

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
MIGRAINE DISORDER	—	GWAS catalog	23793025	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Migraine Disorders	Migraine	Pubtator	27189022	Associate	★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	31427815		★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	34252155	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ZDHHC6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZDHHC6.