ZCRB1 (zinc finger CCHC-type and RNA binding motif containing 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 85437
• Gene name: Zinc finger CCHC-type and RNA binding motif containing 1
• Gene symbol: ZCRB1
• Synonyms (NCBI Gene): MADP-1, MADP1, RBM36, SNRNP31, ZCCHC19
• Chromosome: 12
• Chromosome location: 12q12
• Summary: Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5` splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge conn

miRNA Show/Hide all (40)

miRTarBase ID	miRNA	Experiments	Reference
MIRT439243	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT439244	hsa-miR-382-3p	HITS-CLIP	24374217
MIRT439242	hsa-miR-136-5p	HITS-CLIP	24374217
MIRT439241	hsa-miR-541-5p	HITS-CLIP	24374217
MIRT726077	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726076	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726075	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726073	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726074	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT439243	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT439244	hsa-miR-382-3p	HITS-CLIP	24374217
MIRT439242	hsa-miR-136-5p	HITS-CLIP	24374217
MIRT439241	hsa-miR-541-5p	HITS-CLIP	24374217
MIRT1507568	hsa-miR-129-3p	CLIP-seq
MIRT1507569	hsa-miR-134	CLIP-seq
MIRT1507570	hsa-miR-3118	CLIP-seq
MIRT1507571	hsa-miR-3136-5p	CLIP-seq
MIRT1507572	hsa-miR-3159	CLIP-seq
MIRT1507573	hsa-miR-330-3p	CLIP-seq
MIRT1507574	hsa-miR-3647-3p	CLIP-seq
MIRT1507575	hsa-miR-374a	CLIP-seq
MIRT1507576	hsa-miR-374b	CLIP-seq
MIRT1507577	hsa-miR-3942-3p	CLIP-seq
MIRT1507578	hsa-miR-4439	CLIP-seq
MIRT1507579	hsa-miR-4477a	CLIP-seq
MIRT1507580	hsa-miR-4477b	CLIP-seq
MIRT1507581	hsa-miR-4484	CLIP-seq
MIRT1507582	hsa-miR-450b-3p	CLIP-seq
MIRT1507583	hsa-miR-4513	CLIP-seq
MIRT1507584	hsa-miR-4775	CLIP-seq
MIRT1507585	hsa-miR-548an	CLIP-seq
MIRT1507586	hsa-miR-578	CLIP-seq
MIRT1507587	hsa-miR-633	CLIP-seq
MIRT1507588	hsa-miR-635	CLIP-seq
MIRT1507589	hsa-miR-769-3p	CLIP-seq
MIRT1507590	hsa-miR-938	CLIP-seq
MIRT2152883	hsa-miR-4445	CLIP-seq
MIRT2152884	hsa-miR-873	CLIP-seq
MIRT1507580	hsa-miR-4477b	CLIP-seq
MIRT2152884	hsa-miR-873	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005689	Component	U12-type spliceosomal complex	IBA
GO:0005689	Component	U12-type spliceosomal complex	IDA	15146077
GO:0005689	Component	U12-type spliceosomal complex	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008380	Process	RNA splicing	IC	15146077
GO:0008380	Process	RNA splicing	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 610750
• HGNC: 29620
• e!Ensembl: ENSG00000139168

Protein

• UniProt ID: Q8TBF4
• Protein name: Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein) (U11/U12-31K)
• PDB: 2E5H
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	12 → 82	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00098	zf-CCHC	105 → 122	Zinc knuckle	Domain

• Sequence:

  MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRKSKGVAFILFLD
  KDSAQNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYAC
  PKNMLGEREPPKKKEKKKKKKAPEPEEEIEEVEESEDEGEDPALDSLSQAIAFQQAKIEE
  EQKKWKPSSGVPSTSDDSRRPRIKKSTYFSDEEELSD

• Sequence length: 217

Pathways

Reactome Pathway:

mRNA Splicing - Minor Pathway

Related Genes

No strongly related genes found yet for ZCRB1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZCRB1.