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Gene Gene information from NCBI Gene database.
Entrez ID 340554
Gene name Zinc finger CCCH-type containing 12B
Gene symbol ZC3H12B
Synonyms (NCBI Gene)
CXorf32MCPIP2
Chromosome X
Chromosome location Xq11.2-q12
Summary The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease
miRNA miRNA information provided by mirtarbase database.
615 Show/Hide all (615)
miRTarBase ID miRNA Experiments Reference
MIRT627221 hsa-miR-508-5p HITS-CLIP 23824327
MIRT627220 hsa-miR-371b-3p HITS-CLIP 23824327
MIRT627219 hsa-miR-371a-3p HITS-CLIP 23824327
MIRT627218 hsa-miR-33b-3p HITS-CLIP 23824327
MIRT627217 hsa-miR-515-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9 Show/Hide all (9)
GO ID Ontology Definition Evidence Reference
GO:0003729 Function MRNA binding IBA
GO:0004518 Function Nuclease activity IEA
GO:0004519 Function Endonuclease activity IEA
GO:0004521 Function RNA endonuclease activity IBA
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
300889 17407 ENSG00000102053
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5HYM0
Protein name Probable ribonuclease ZC3H12B (EC 3.1.-.-) (MCP-induced protein 2) (Zinc finger CCCH domain-containing protein 12B)
Protein function May function as RNase and regulate the levels of target RNA species.
PDB 6SJD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11977 RNase_Zc3h12a 189 → 345 Zc3h12a-like Ribonuclease NYN domain Domain
PF18039 UBA_6 108 → 149 UBA-like domain Domain
PF18561 Regnase_1_C 790 → 831 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain Domain
Sequence
MTATAEVETPKMEKSASKEEKQQPKQDSTEQGNADSEEWMSSESDPEQISLKSSDNSKSC
QPRDGQLKKKEMHSKPHRQLCRSPCLDRPSFSQSSILQDGKLDLEKEYQAKMEFALKLGY
AEEQIQSVLNKLGPESLINDVLAELVRLG
NKGDSEGQINLSLLVPRGPSSREIASPELSL
EDEIDNSDNLRPVVIDGSNVAMSHGNKEEFSCRGIQLAVDWFLDKGHKDITVFVPAWRKE
QSRPDAPITDQDILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFDSDGIIVSNDN
YRDLQVEKPEWKKFIEERLLMYSFVNDKFMPPDDPLGRHGPSLEN
FLRKRPIVPEHKKQP
CPYGKKCTYGHKCKYYHPERANQPQRSVADELRISAKLSTVKTMSEGTLAKCGTGMSSAK
GEITSEVKRVAPKRQSDPSIRSVAMEPEEWLSIARKPEASSVPSLVTALSVPTIPPPKSH
AVGALNTRSASSPVPGSSHFPHQKASLEHMASMQYPPILVTNSHGTPISYAEQYPKFESM
GDHGYYSMLGDFSKLNINSMHNREYYMAEVDRGVYARNPNLCSDSRVSHTRNDNYSSYNN
VYLAVADTHPEGNLKLHRSASQNRLQPFPHGYHEALTRVQSYGPEDSKQGPHKQSVPHLA
LHAQHPSTGTRSSCPADYPMPPNIHPGATPQPGRALVMTRMDSISDSRLYESNPVRQRRP
PLCREQHASWDPLPCTTDSYGYHSYPLSNSLMQPCYEPVMVRSVPEKMEQLWRNPWVGMC
NDSREHMIPEHQYQTYKNLCNIFPSNIVLAVMEKNPHTADAQQLAALIVAKLRAAR
Sequence length 836
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (7)
Phenotype Name Clinical Significance Source Reference Evidence Score
ANDROGENETIC ALOPECIA — GWAS catalog 28196072
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER — GenCC —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ERECTILE DYSFUNCTION — GWAS catalog 20932654
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPOGONADISM — GWAS catalog 40316537
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 32961112 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 34482648 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 38238463 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Neuroblastoma Neuroblastoma Pubtator 30988100 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only