ZBTB8OS (zinc finger and BTB domain containing 8 opposite strand)

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Gene Gene information from NCBI Gene database.
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Entrez ID 339487
Gene name Zinc finger and BTB domain containing 8 opposite strand
Gene symbol ZBTB8OS
Synonyms (NCBI Gene)
ARCHARCH2
Chromosome 1
Chromosome location 1p35.1
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT050263 hsa-miR-25-3p CLASH 23622248
MIRT516095 hsa-miR-6888-5p HITS-CLIP 23706177
MIRT516093 hsa-miR-3929 HITS-CLIP 23706177
MIRT516092 hsa-miR-4419b HITS-CLIP 23706177
MIRT516091 hsa-miR-4478 HITS-CLIP 23706177
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 24870230, 32296183, 32814053
GO:0005634 Component Nucleus NAS 21311021
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm NAS 21311021
GO:0006388 Process TRNA splicing, via endonucleolytic cleavage and ligation IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
615891 24094 ENSG00000176261
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IWT0
Protein name Protein archease (Protein ZBTB8OS) (Zinc finger and BTB domain-containing opposite strand protein 8)
Protein function Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. {ECO:0000269|Pub
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01951 Archease 31 → 167 Archease protein family (MTH1598/TM1083) Domain
Sequence
Sequence length 167
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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Reactome Pathway
tRNA processing in the nucleus
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Familial cancer of breast Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Osteoporosis, Postmenopausal Osteoporosis BEFREE 30389901
★★★★★
★☆☆☆☆
Found in Text Mining only
Primary Myelofibrosis Myelofibrosis BEFREE 31776465
★★★★★
★☆☆☆☆
Found in Text Mining only
Xeroderma Pigmentosum, Complementation Group D Xeroderma Pigmentosum BEFREE 23382212
★★★★★
★☆☆☆☆
Found in Text Mining only

No strongly related genes found yet for ZBTB8OS.

No additional diseases found yet through genes similar to ZBTB8OS.