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Gene Gene information from NCBI Gene database.
Entrez ID 10009
Gene name Zinc finger and BTB domain containing 33
Gene symbol ZBTB33
Synonyms (NCBI Gene)
ZNF-kaisoZNF348
Chromosome X
Chromosome location Xq24
Summary This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zin
miRNA miRNA information provided by mirtarbase database.
648 Show/Hide all (648)
miRTarBase ID miRNA Experiments Reference
MIRT024596 hsa-miR-215-5p Microarray 19074876
MIRT026285 hsa-miR-192-5p Microarray 19074876
MIRT028064 hsa-miR-93-5p Sequencing 20371350
MIRT045104 hsa-miR-186-5p CLASH 23622248
MIRT044097 hsa-miR-361-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27 Show/Hide all (27)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
300329 16682 ENSG00000177485
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86T24
Protein name Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)
Protein function Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso bin
PDB 2LT7 , 3FKC , 3M4T , 3M8V , 4F6M , 4F6N , 5VMU , 5VMV , 5VMW , 5VMX , 5VMY , 5VMZ , 6DF5 , 6DF8 , 6DF9 , 6DFA , 6DFB , 6DFC , 6V8U
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 22 → 120 BTB/POZ domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in vascular endothelium. {ECO:0000269|PubMed:14699141}.
Sequence
MESRKLISATDIQYSGSLLNSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQL
FSVAGQVVELSFIRAEIFAEILNYIYSSKIVRVRSDLLDELIKSGQLLGVKFIAELGVPL

SQVKSISGTAQDGNTEPLPPDSGDKNLVIQKSKDEAQDNGATIMPIITESFSLSAEDYEM
KKIIVTDSDDDDDDVIFCSEILPTKETLPSNNTVAQVQSNPGPVAISDVAPSASNNSPPL
TNITPTQKLPTPVNQATLSQTQGSEKLLVSSAPTHLTPNIILLNQTPLSTPPNVSSSLPN
HMPSSINLLVQNQQTPNSAILTGNKANEEEEEEIIDDDDDTISSSPDSAVSNTSLVPQAD
TSQNTSFDGSLIQKMQIPTLLQEPLSNSLKISDIITRNTNDPGVGSKHLMEGQKIITLDT
ATEIEGLSTGCKVYANIGEDTYDIVIPVKDDPDEGEARLENEIPKTSGSEMANKRMKVKH
DDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVFPLAEYRTKH
EIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGDSKLYRLHPCRSLQIRQYAYL
SDRSSTIPAMKDDGIGYKVDTGKEPPVGTTTSTQNKPMTWEDIFIQQENDSIFKQNVTDG
STEFEFIIPESY
Sequence length 672
Interactions View interactions