ZBTB21 (zinc finger and BTB domain containing 21)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 49854
• Gene name: Zinc finger and BTB domain containing 21
• Gene symbol: ZBTB21
• Synonyms (NCBI Gene): ZNF295
• Chromosome: 21
• Chromosome location: 21q22.3

miRNA Show/Hide all (55)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016244	hsa-miR-548b-3p	Sequencing	20371350
MIRT021195	hsa-miR-186-5p	Sequencing	20371350
MIRT021681	hsa-miR-140-3p	Sequencing	20371350
MIRT027301	hsa-miR-101-3p	Sequencing	20371350
MIRT028047	hsa-miR-93-5p	Sequencing	20371350
MIRT044137	hsa-miR-30e-5p	CLASH	23622248
MIRT039313	hsa-miR-425-5p	CLASH	23622248
MIRT651383	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT651382	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT651380	hsa-miR-3919	HITS-CLIP	23824327
MIRT651381	hsa-miR-4756-3p	HITS-CLIP	23824327
MIRT651379	hsa-miR-6784-3p	HITS-CLIP	23824327
MIRT651378	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT651377	hsa-miR-4469	HITS-CLIP	23824327
MIRT651376	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT651375	hsa-miR-4287	HITS-CLIP	23824327
MIRT651374	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT651373	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT651372	hsa-miR-383-5p	HITS-CLIP	23824327
MIRT651371	hsa-miR-4772-5p	HITS-CLIP	23824327
MIRT651370	hsa-miR-569	HITS-CLIP	23824327
MIRT651369	hsa-miR-2053	HITS-CLIP	23824327
MIRT651368	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT564811	hsa-miR-4282	PAR-CLIP	20371350
MIRT021195	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT351323	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT564810	hsa-miR-4715-5p	PAR-CLIP	20371350
MIRT564809	hsa-miR-875-5p	PAR-CLIP	20371350
MIRT404072	hsa-miR-3119	PAR-CLIP	20371350
MIRT564808	hsa-miR-488-3p	PAR-CLIP	20371350
MIRT564807	hsa-miR-510-3p	PAR-CLIP	20371350
MIRT651383	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT651382	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT651380	hsa-miR-3919	HITS-CLIP	23824327
MIRT651381	hsa-miR-4756-3p	HITS-CLIP	23824327
MIRT651379	hsa-miR-6784-3p	HITS-CLIP	23824327
MIRT651378	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT651377	hsa-miR-4469	HITS-CLIP	23824327
MIRT651376	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT651375	hsa-miR-4287	HITS-CLIP	23824327
MIRT651374	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT651373	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT651372	hsa-miR-383-5p	HITS-CLIP	23824327
MIRT651371	hsa-miR-4772-5p	HITS-CLIP	23824327
MIRT651370	hsa-miR-569	HITS-CLIP	23824327
MIRT651369	hsa-miR-2053	HITS-CLIP	23824327
MIRT651368	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT564811	hsa-miR-4282	PAR-CLIP	20371350
MIRT021195	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT351323	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT564810	hsa-miR-4715-5p	PAR-CLIP	20371350
MIRT564809	hsa-miR-875-5p	PAR-CLIP	20371350
MIRT404072	hsa-miR-3119	PAR-CLIP	20371350
MIRT564808	hsa-miR-488-3p	PAR-CLIP	20371350
MIRT564807	hsa-miR-510-3p	PAR-CLIP	20371350

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	15629158
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	15629158
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	15629158, 28514442, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	15629158
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008327	Function	Methyl-CpG binding	IDA	21029866
GO:0031208	Function	POZ domain binding	IDA	15629158
GO:0042802	Function	Identical protein binding	IPI	15629158
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 616485
• HGNC: 13083
• e!Ensembl: ENSG00000173276

Protein

• UniProt ID: Q9ULJ3
• Protein name: Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295)
• Protein function: Acts as a transcription repressor.
• PDB: 1WJP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	670 → 692	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	1043 → 1065	Zinc finger, C2H2 type	Domain
  PF00651	BTB	20 → 124	BTB/POZ domain	Domain
  PF18450	zf_C2H2_6	746 → 773	Zinc Finger domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous in fetal and adult tissues. {ECO:0000269|PubMed:15629158}.
• Sequence:

  MEGLLHYINPAHAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFT
  NKENESQTVFQLDFCEPDAFDNVLNYIYSSSLFVEKSSLAAVQELGYSLGISFLTNIVSK
  TPQAPFPTCPNRKKVFVEDDENSSQKRSVIVCQSRNEAQGKTVSQNQPDVSHTSRPSPSI
  AVKANTNKPHVPKPIEPLHNLSLTEKSWPKDSSVVYAKSLEHSGSLDDPNRISLVKRNAV
  LPSKPLQDREAMDDKPGVSGQLPKGKALELALKRPRPPVLSVCSSSETPYLLKETNKGNG
  QGEDRNLLYYSKLGLVIPSSGSGSGNQSIDRSGPLVKSLLRRSLSMDSQVPVYSPSIDLK
  SSQGSSSVSSDAPGNVLCALSQKSSLKDCSEKTALDDRPQVLQPHRLRSFSASQSTDREG
  ASPVTEVRIKTEPSSPLSDPSDIIRVTVGDAATTAAASSSSVTRDLSLKTEDDQKDMSRL
  PAKRRFQADRRLPFKKLKVNEHGSPVSEDNFEEGSSPTLLDADFPDSDLNKDEFGELEGT
  RPNKKFKCKHCLKIFRSTAGLHRHVNMYHNPEKPYACDICHKRFHTNFKVWTHCQTQHGI
  VKNPSPASSSHAVLDEKFQRKLIDIVREREIKKALIIKLRRGKPGFQGQSSSQAQQVIKR
  NLRSRAKGAYICTYCGKAYRFLSQFKQHIKMHPGEKPLGVNKVAKPKEHAPLASPVENKE
  VYQCRLCNAKLSSLLEQGSHERLCRNAAVCPYCSLRFFSPELKQEHESKCEYKKLTCLEC
  MRTFKSSFSIWRHQVEVHNQNNMAPTENFSLPVLDHNGDVTGSSRPQSQPEPNKVNHIVT
  TKDDNVFSDSSEQVNFDSEDSSCLPEDLSLSKQLKIQVKEEPVEEAEEEAPEASTAPKEA
  GPSKEASLWPCEKCGKMFTVHKQLERHQELLCSVKPFICHVCNKAFRTNFRLWSHFQSHM
  SQASEESAHKESEVCPVPTNSPSPPPLPPPPPLPKIQPLEPDSPTGLSENPTPATEKLFV
  PQESDTLFYHAPPLSAITFKRQFMCKLCHRTFKTAFSLWSHEQTHN

• Sequence length: 1066

Related Genes

No strongly related genes found yet for ZBTB21.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZBTB21.