ZBTB1 (zinc finger and BTB domain containing 1)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 22890
• Gene name: Zinc finger and BTB domain containing 1
• Gene symbol: ZBTB1
• Synonyms (NCBI Gene): ZNF909
• Chromosome: 14
• Chromosome location: 14q23.3

miRNA Show/Hide all (131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017131	hsa-miR-335-5p	Microarray	18185580
MIRT1502018	hsa-miR-101	CLIP-seq
MIRT1502019	hsa-miR-10a	CLIP-seq
MIRT1502020	hsa-miR-10b	CLIP-seq
MIRT1502021	hsa-miR-1279	CLIP-seq
MIRT1502022	hsa-miR-1303	CLIP-seq
MIRT1502023	hsa-miR-144	CLIP-seq
MIRT1502024	hsa-miR-190	CLIP-seq
MIRT1502025	hsa-miR-190b	CLIP-seq
MIRT1502026	hsa-miR-216a	CLIP-seq
MIRT1502027	hsa-miR-23a	CLIP-seq
MIRT1502028	hsa-miR-23b	CLIP-seq
MIRT1502029	hsa-miR-23c	CLIP-seq
MIRT1502030	hsa-miR-300	CLIP-seq
MIRT1502031	hsa-miR-3121-3p	CLIP-seq
MIRT1502032	hsa-miR-3121-5p	CLIP-seq
MIRT1502033	hsa-miR-3160-5p	CLIP-seq
MIRT1502034	hsa-miR-3180-5p	CLIP-seq
MIRT1502035	hsa-miR-362-5p	CLIP-seq
MIRT1502036	hsa-miR-3664-5p	CLIP-seq
MIRT1502037	hsa-miR-3668	CLIP-seq
MIRT1502038	hsa-miR-371-5p	CLIP-seq
MIRT1502039	hsa-miR-371b-5p	CLIP-seq
MIRT1502040	hsa-miR-380	CLIP-seq
MIRT1502041	hsa-miR-381	CLIP-seq
MIRT1502042	hsa-miR-3924	CLIP-seq
MIRT1502043	hsa-miR-3973	CLIP-seq
MIRT1502044	hsa-miR-410	CLIP-seq
MIRT1502045	hsa-miR-4263	CLIP-seq
MIRT1502046	hsa-miR-452	CLIP-seq
MIRT1502047	hsa-miR-4676-3p	CLIP-seq
MIRT1502048	hsa-miR-4677-3p	CLIP-seq
MIRT1502049	hsa-miR-4679	CLIP-seq
MIRT1502050	hsa-miR-4686	CLIP-seq
MIRT1502051	hsa-miR-4694-5p	CLIP-seq
MIRT1502052	hsa-miR-4714-5p	CLIP-seq
MIRT1502053	hsa-miR-4717-3p	CLIP-seq
MIRT1502054	hsa-miR-4719	CLIP-seq
MIRT1502055	hsa-miR-4725-5p	CLIP-seq
MIRT1502056	hsa-miR-4760-3p	CLIP-seq
MIRT1502057	hsa-miR-4762-5p	CLIP-seq
MIRT1502058	hsa-miR-487a	CLIP-seq
MIRT1502059	hsa-miR-495	CLIP-seq
MIRT1502060	hsa-miR-500b	CLIP-seq
MIRT1502061	hsa-miR-501-5p	CLIP-seq
MIRT1502062	hsa-miR-504	CLIP-seq
MIRT1502063	hsa-miR-511	CLIP-seq
MIRT1502064	hsa-miR-513a-3p	CLIP-seq
MIRT1502065	hsa-miR-513c	CLIP-seq
MIRT1502066	hsa-miR-514b-5p	CLIP-seq
MIRT1502067	hsa-miR-520a-5p	CLIP-seq
MIRT1502068	hsa-miR-520g	CLIP-seq
MIRT1502069	hsa-miR-520h	CLIP-seq
MIRT1502070	hsa-miR-525-5p	CLIP-seq
MIRT1502071	hsa-miR-548ae	CLIP-seq
MIRT1502072	hsa-miR-548aj	CLIP-seq
MIRT1502073	hsa-miR-548am	CLIP-seq
MIRT1502074	hsa-miR-548g	CLIP-seq
MIRT1502075	hsa-miR-548x	CLIP-seq
MIRT1502076	hsa-miR-561	CLIP-seq
MIRT1502077	hsa-miR-576-5p	CLIP-seq
MIRT1502078	hsa-miR-587	CLIP-seq
MIRT1502079	hsa-miR-603	CLIP-seq
MIRT1502080	hsa-miR-633	CLIP-seq
MIRT1502081	hsa-miR-654-3p	CLIP-seq
MIRT1502082	hsa-miR-671-5p	CLIP-seq
MIRT1502083	hsa-miR-877	CLIP-seq
MIRT1502084	hsa-miR-889	CLIP-seq
MIRT1502085	hsa-miR-9	CLIP-seq
MIRT1502086	hsa-miR-944	CLIP-seq
MIRT1502087	hsa-miR-1225-5p	CLIP-seq
MIRT1502088	hsa-miR-25	CLIP-seq
MIRT1502089	hsa-miR-298	CLIP-seq
MIRT1502090	hsa-miR-3145-3p	CLIP-seq
MIRT1502091	hsa-miR-32	CLIP-seq
MIRT1502092	hsa-miR-363	CLIP-seq
MIRT1502093	hsa-miR-367	CLIP-seq
MIRT1502094	hsa-miR-3678-3p	CLIP-seq
MIRT1502095	hsa-miR-92a	CLIP-seq
MIRT1502096	hsa-miR-92b	CLIP-seq
MIRT2150922	hsa-miR-1295	CLIP-seq
MIRT2150923	hsa-miR-148a	CLIP-seq
MIRT2150924	hsa-miR-148b	CLIP-seq
MIRT2150925	hsa-miR-152	CLIP-seq
MIRT1502031	hsa-miR-3121-3p	CLIP-seq
MIRT1502032	hsa-miR-3121-5p	CLIP-seq
MIRT1502035	hsa-miR-362-5p	CLIP-seq
MIRT2150926	hsa-miR-3653	CLIP-seq
MIRT2150927	hsa-miR-3658	CLIP-seq
MIRT1502037	hsa-miR-3668	CLIP-seq
MIRT2150928	hsa-miR-374a	CLIP-seq
MIRT2150929	hsa-miR-374b	CLIP-seq
MIRT2150930	hsa-miR-3935	CLIP-seq
MIRT1502044	hsa-miR-410	CLIP-seq
MIRT2150931	hsa-miR-4252	CLIP-seq
MIRT1502045	hsa-miR-4263	CLIP-seq
MIRT2150932	hsa-miR-4276	CLIP-seq
MIRT2150933	hsa-miR-4282	CLIP-seq
MIRT2150934	hsa-miR-4517	CLIP-seq
MIRT2150935	hsa-miR-4668-3p	CLIP-seq
MIRT1502050	hsa-miR-4686	CLIP-seq
MIRT1502051	hsa-miR-4694-5p	CLIP-seq
MIRT2150936	hsa-miR-4717-5p	CLIP-seq
MIRT2150937	hsa-miR-4760-5p	CLIP-seq
MIRT2150938	hsa-miR-4774-3p	CLIP-seq
MIRT1502059	hsa-miR-495	CLIP-seq
MIRT1502060	hsa-miR-500b	CLIP-seq
MIRT1502061	hsa-miR-501-5p	CLIP-seq
MIRT1502077	hsa-miR-576-5p	CLIP-seq
MIRT1502085	hsa-miR-9	CLIP-seq
MIRT2150923	hsa-miR-148a	CLIP-seq
MIRT2150924	hsa-miR-148b	CLIP-seq
MIRT2150925	hsa-miR-152	CLIP-seq
MIRT2371563	hsa-miR-223	CLIP-seq
MIRT1502027	hsa-miR-23a	CLIP-seq
MIRT1502028	hsa-miR-23b	CLIP-seq
MIRT1502029	hsa-miR-23c	CLIP-seq
MIRT2150928	hsa-miR-374a	CLIP-seq
MIRT2150929	hsa-miR-374b	CLIP-seq
MIRT2150932	hsa-miR-4276	CLIP-seq
MIRT2371564	hsa-miR-4307	CLIP-seq
MIRT2371565	hsa-miR-4328	CLIP-seq
MIRT2371566	hsa-miR-4695-3p	CLIP-seq
MIRT1502053	hsa-miR-4717-3p	CLIP-seq
MIRT1502056	hsa-miR-4760-3p	CLIP-seq
MIRT2150937	hsa-miR-4760-5p	CLIP-seq
MIRT2371567	hsa-miR-4773	CLIP-seq
MIRT2150938	hsa-miR-4774-3p	CLIP-seq
MIRT2371568	hsa-miR-4776-3p	CLIP-seq
MIRT2371569	hsa-miR-541	CLIP-seq
MIRT2371570	hsa-miR-654-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	20797634, 21706167
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA
GO:0001817	Process	Regulation of cytokine production	IBA
GO:0002376	Process	Immune system process	IEA
GO:0002682	Process	Regulation of immune system process	IBA
GO:0002711	Process	Positive regulation of T cell mediated immunity	IEA
GO:0002711	Process	Positive regulation of T cell mediated immunity	ISS
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	20211142, 24657165, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IDA	21706167
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA	20797634
GO:0005654	Component	Nucleoplasm	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IMP	24657165
GO:0006338	Process	Chromatin remodeling	IMP	24657165
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	24657165
GO:0008270	Function	Zinc ion binding	IEA
GO:0016604	Component	Nuclear body	IDA	20797634
GO:0019985	Process	Translesion synthesis	IMP	24657165
GO:0030154	Process	Cell differentiation	IEA
GO:0030183	Process	B cell differentiation	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0032825	Process	Positive regulation of natural killer cell differentiation	IEA
GO:0032825	Process	Positive regulation of natural killer cell differentiation	ISS
GO:0033077	Process	T cell differentiation in thymus	IEA
GO:0034644	Process	Cellular response to UV	IMP	24657165
GO:0042789	Process	MRNA transcription by RNA polymerase II	IDA	21706167
GO:0042803	Function	Protein homodimerization activity	IDA	22753936
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0045582	Process	Positive regulation of T cell differentiation	IEA
GO:0045582	Process	Positive regulation of T cell differentiation	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0046982	Function	Protein heterodimerization activity	IDA	22753936
GO:0048538	Process	Thymus development	IEA
GO:0048538	Process	Thymus development	ISS
GO:0051260	Process	Protein homooligomerization	IDA	20797634
GO:0070530	Function	K63-linked polyubiquitin modification-dependent protein binding	IDA	24657165
GO:2000176	Process	Positive regulation of pro-T cell differentiation	IEA
GO:2000176	Process	Positive regulation of pro-T cell differentiation	ISS

Other IDs

• MIM: 616578
• HGNC: 20259
• e!Ensembl: ENSG00000126804

Protein

• UniProt ID: Q9Y2K1
• Protein name: Zinc finger and BTB domain-containing protein 1
• Protein function: Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading,
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00651	BTB	14 → 120	BTB/POZ domain	Domain

• Sequence:

  MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHST
  AQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDAD
  CSSSKCSSSASSKQNSKMIFGVRMYEDTVARNGNEANRWCAEPSSTVNTPHNREADEESL
  QLGNFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTN
  RHLYQNTRSYHRIVDIRDGKDSNIKAEFGEKDSSKTFSAQTDKYRGDTSQAADDSASTTG
  SRKSSTVESEIASEEKSRAAERKRIIIKMEPEDIPTDELKDFNIIKVTDKDCNESTDNDE
  LEDEPEEPFYRYYVEEDVSIKKSGRKTLKPRMSVSADERGGLENMRPPNNSSPVQEDAEN
  ASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNG
  LGNTEEKMDLEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCG
  QRFETENLVVEHMSSCLDQDMFKSAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVH
  TKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSAG
  ETICQVCFQIFPNNEQLEQHMDVHLYTCGICGAKFNLRKDMRSHYNAKHLKRT

• Sequence length: 713

Related Genes

No strongly related genes found yet for ZBTB1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZBTB1.