YBEY (ybeY metalloendoribonuclease)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 54059
• Gene name: YbeY metalloendoribonuclease
• Gene symbol: YBEY
• Synonyms (NCBI Gene): C21orf57
• Chromosome: 21
• Chromosome location: 21q22.3
• Summary: This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. [pr

miRNA Show/Hide all (44)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1498313	hsa-miR-1273d	CLIP-seq
MIRT1498314	hsa-miR-214	CLIP-seq
MIRT1498315	hsa-miR-3165	CLIP-seq
MIRT1498316	hsa-miR-3619-5p	CLIP-seq
MIRT1498317	hsa-miR-4291	CLIP-seq
MIRT1498318	hsa-miR-4660	CLIP-seq
MIRT1498319	hsa-miR-548b-3p	CLIP-seq
MIRT1498320	hsa-miR-761	CLIP-seq
MIRT1498321	hsa-miR-885-3p	CLIP-seq
MIRT1498322	hsa-miR-922	CLIP-seq
MIRT1921078	hsa-miR-1470	CLIP-seq
MIRT1921079	hsa-miR-205	CLIP-seq
MIRT1921080	hsa-miR-2117	CLIP-seq
MIRT1921081	hsa-miR-4273	CLIP-seq
MIRT1921082	hsa-miR-4287	CLIP-seq
MIRT1921083	hsa-miR-4469	CLIP-seq
MIRT1921084	hsa-miR-4667-3p	CLIP-seq
MIRT1921085	hsa-miR-4685-3p	CLIP-seq
MIRT1921086	hsa-miR-4768-5p	CLIP-seq
MIRT1921078	hsa-miR-1470	CLIP-seq
MIRT1921079	hsa-miR-205	CLIP-seq
MIRT1921080	hsa-miR-2117	CLIP-seq
MIRT1921081	hsa-miR-4273	CLIP-seq
MIRT1921082	hsa-miR-4287	CLIP-seq
MIRT1921083	hsa-miR-4469	CLIP-seq
MIRT1921084	hsa-miR-4667-3p	CLIP-seq
MIRT1921085	hsa-miR-4685-3p	CLIP-seq
MIRT1921086	hsa-miR-4768-5p	CLIP-seq
MIRT1498314	hsa-miR-214	CLIP-seq
MIRT1498316	hsa-miR-3619-5p	CLIP-seq
MIRT1498317	hsa-miR-4291	CLIP-seq
MIRT1498320	hsa-miR-761	CLIP-seq
MIRT1498322	hsa-miR-922	CLIP-seq
MIRT2370322	hsa-miR-3152-3p	CLIP-seq
MIRT2370323	hsa-miR-767-3p	CLIP-seq
MIRT1921078	hsa-miR-1470	CLIP-seq
MIRT1921079	hsa-miR-205	CLIP-seq
MIRT1921080	hsa-miR-2117	CLIP-seq
MIRT1921081	hsa-miR-4273	CLIP-seq
MIRT1921082	hsa-miR-4287	CLIP-seq
MIRT1921083	hsa-miR-4469	CLIP-seq
MIRT1921084	hsa-miR-4667-3p	CLIP-seq
MIRT1921085	hsa-miR-4685-3p	CLIP-seq
MIRT1921086	hsa-miR-4768-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004521	Function	RNA endonuclease activity	IDA	28153719
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005634	Component	Nucleus	IDA	22042635
GO:0005634	Component	Nucleus	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0006364	Process	RRNA processing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 617461
• HGNC: 1299
• e!Ensembl: ENSG00000182362

Protein

• UniProt ID: P58557
• Protein name: Endoribonuclease YbeY (EC 3.1.-.-)
• Protein function: Single strand-specific metallo-endoribonuclease involved in rRNA maturation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02130	UPF0054	14 → 148	Uncharacterized protein family UPF0054	Family

• Sequence:

  MSLVIRNLQRVIPIRRAPLRSKIEIVRRILGVQKFDLGIICVDNKNIQHINRIYRDRNVP
  TDVLSFPFHEHLKAGEFPQPDFPDDYNLGDIFLGVEYIFHQCKENEDYNDVLTVTATHGL
  CHLLGFTHGTEAEWQQMFQKEKAVLDELGRRTGTRLQPLTRGLFGGS

• Sequence length: 167

Related Genes

No strongly related genes found yet for YBEY.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to YBEY.