XPO6 (exportin 6)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 23214
• Gene name: Exportin 6
• Gene symbol: XPO6
• Synonyms (NCBI Gene): EXP6, RANBP20
• Chromosome: 16
• Chromosome location: 16p12.1
• Summary: The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-a

miRNA Show/Hide all (190)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003106	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT002751	hsa-miR-1-3p	Microarray	15685193
MIRT002751	hsa-miR-1-3p	Immunoblot, Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22210864
MIRT002751	hsa-miR-1-3p	Immunoblot, Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22210864
MIRT002751	hsa-miR-1-3p	Immunoblot, Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22210864
MIRT002751	hsa-miR-1-3p	Microarray	15685193
MIRT002751	hsa-miR-1-3p	Microarray	18668037
MIRT051247	hsa-miR-16-5p	CLASH	23622248
MIRT047267	hsa-miR-181b-5p	CLASH	23622248
MIRT046690	hsa-miR-222-3p	CLASH	23622248
MIRT045379	hsa-miR-185-5p	CLASH	23622248
MIRT044849	hsa-miR-320a	CLASH	23622248
MIRT043121	hsa-miR-324-5p	CLASH	23622248
MIRT689560	hsa-miR-576-3p	HITS-CLIP	23313552
MIRT689559	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT689558	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT689557	hsa-miR-940	HITS-CLIP	23313552
MIRT689556	hsa-miR-4491	HITS-CLIP	23313552
MIRT689555	hsa-miR-4657	HITS-CLIP	23313552
MIRT689554	hsa-miR-4514	HITS-CLIP	23313552
MIRT689553	hsa-miR-4692	HITS-CLIP	23313552
MIRT689552	hsa-miR-1827	HITS-CLIP	23313552
MIRT689551	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT689550	hsa-miR-6820-5p	HITS-CLIP	23313552
MIRT689549	hsa-miR-766-5p	HITS-CLIP	23313552
MIRT689548	hsa-miR-7154-3p	HITS-CLIP	23313552
MIRT689547	hsa-miR-765	HITS-CLIP	23313552
MIRT689546	hsa-miR-6894-5p	HITS-CLIP	23313552
MIRT689545	hsa-miR-31-5p	HITS-CLIP	23313552
MIRT689544	hsa-miR-885-3p	HITS-CLIP	23313552
MIRT689543	hsa-miR-7847-3p	HITS-CLIP	23313552
MIRT689542	hsa-miR-1273e	HITS-CLIP	23313552
MIRT449094	hsa-miR-3188	PAR-CLIP	22100165
MIRT449093	hsa-miR-1908-5p	PAR-CLIP	22100165
MIRT449092	hsa-miR-663a	PAR-CLIP	22100165
MIRT449091	hsa-miR-6787-5p	PAR-CLIP	22100165
MIRT449089	hsa-miR-6825-5p	PAR-CLIP	22100165
MIRT449090	hsa-miR-3180	PAR-CLIP	22100165
MIRT449088	hsa-miR-3180-3p	PAR-CLIP	22100165
MIRT449087	hsa-miR-3196	PAR-CLIP	22100165
MIRT449086	hsa-miR-6816-5p	PAR-CLIP	22100165
MIRT449085	hsa-miR-4723-5p	PAR-CLIP	22100165
MIRT449084	hsa-miR-5698	PAR-CLIP	22100165
MIRT449083	hsa-miR-6870-5p	PAR-CLIP	22100165
MIRT449082	hsa-miR-7111-5p	PAR-CLIP	22100165
MIRT449081	hsa-miR-1227-5p	PAR-CLIP	22100165
MIRT449080	hsa-miR-4260	PAR-CLIP	22100165
MIRT689560	hsa-miR-576-3p	HITS-CLIP	23313552
MIRT689559	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT689558	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT689557	hsa-miR-940	HITS-CLIP	23313552
MIRT689556	hsa-miR-4491	HITS-CLIP	23313552
MIRT689555	hsa-miR-4657	HITS-CLIP	23313552
MIRT689554	hsa-miR-4514	HITS-CLIP	23313552
MIRT689553	hsa-miR-4692	HITS-CLIP	23313552
MIRT689552	hsa-miR-1827	HITS-CLIP	23313552
MIRT689551	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT689550	hsa-miR-6820-5p	HITS-CLIP	23313552
MIRT689549	hsa-miR-766-5p	HITS-CLIP	23313552
MIRT689548	hsa-miR-7154-3p	HITS-CLIP	23313552
MIRT689547	hsa-miR-765	HITS-CLIP	23313552
MIRT689546	hsa-miR-6894-5p	HITS-CLIP	23313552
MIRT689545	hsa-miR-31-5p	HITS-CLIP	23313552
MIRT689544	hsa-miR-885-3p	HITS-CLIP	23313552
MIRT689543	hsa-miR-7847-3p	HITS-CLIP	23313552
MIRT689542	hsa-miR-1273e	HITS-CLIP	23313552
MIRT449094	hsa-miR-3188	PAR-CLIP	22100165
MIRT449093	hsa-miR-1908-5p	PAR-CLIP	22100165
MIRT449092	hsa-miR-663a	PAR-CLIP	22100165
MIRT449091	hsa-miR-6787-5p	PAR-CLIP	22100165
MIRT449089	hsa-miR-6825-5p	PAR-CLIP	22100165
MIRT449090	hsa-miR-3180	PAR-CLIP	22100165
MIRT449088	hsa-miR-3180-3p	PAR-CLIP	22100165
MIRT449087	hsa-miR-3196	PAR-CLIP	22100165
MIRT449086	hsa-miR-6816-5p	PAR-CLIP	22100165
MIRT449085	hsa-miR-4723-5p	PAR-CLIP	22100165
MIRT449084	hsa-miR-5698	PAR-CLIP	22100165
MIRT449083	hsa-miR-6870-5p	PAR-CLIP	22100165
MIRT449082	hsa-miR-7111-5p	PAR-CLIP	22100165
MIRT449081	hsa-miR-1227-5p	PAR-CLIP	22100165
MIRT449080	hsa-miR-4260	PAR-CLIP	22100165
MIRT1496742	hsa-miR-1	CLIP-seq
MIRT1496743	hsa-miR-122	CLIP-seq
MIRT1496744	hsa-miR-1253	CLIP-seq
MIRT1496745	hsa-miR-206	CLIP-seq
MIRT1496746	hsa-miR-3189-3p	CLIP-seq
MIRT1496747	hsa-miR-3189-5p	CLIP-seq
MIRT1496748	hsa-miR-3192	CLIP-seq
MIRT1496749	hsa-miR-3652	CLIP-seq
MIRT1496750	hsa-miR-3663-5p	CLIP-seq
MIRT1496751	hsa-miR-3673	CLIP-seq
MIRT1496752	hsa-miR-3922-5p	CLIP-seq
MIRT1496753	hsa-miR-4314	CLIP-seq
MIRT1496754	hsa-miR-4327	CLIP-seq
MIRT1496755	hsa-miR-4430	CLIP-seq
MIRT1496756	hsa-miR-4434	CLIP-seq
MIRT1496757	hsa-miR-4440	CLIP-seq
MIRT1496758	hsa-miR-4505	CLIP-seq
MIRT1496759	hsa-miR-4516	CLIP-seq
MIRT1496760	hsa-miR-4527	CLIP-seq
MIRT1496761	hsa-miR-4640-5p	CLIP-seq
MIRT1496762	hsa-miR-4646-5p	CLIP-seq
MIRT1496763	hsa-miR-4710	CLIP-seq
MIRT1496764	hsa-miR-4726-5p	CLIP-seq
MIRT1496765	hsa-miR-4746-3p	CLIP-seq
MIRT1496766	hsa-miR-4786-3p	CLIP-seq
MIRT1496767	hsa-miR-4790-3p	CLIP-seq
MIRT1496768	hsa-miR-4792	CLIP-seq
MIRT1496769	hsa-miR-574-5p	CLIP-seq
MIRT1496770	hsa-miR-613	CLIP-seq
MIRT1496771	hsa-miR-647	CLIP-seq
MIRT1496742	hsa-miR-1	CLIP-seq
MIRT1496743	hsa-miR-122	CLIP-seq
MIRT1496744	hsa-miR-1253	CLIP-seq
MIRT2149595	hsa-miR-1272	CLIP-seq
MIRT2149596	hsa-miR-1343	CLIP-seq
MIRT2149597	hsa-miR-1470	CLIP-seq
MIRT2149598	hsa-miR-182	CLIP-seq
MIRT2149599	hsa-miR-1908	CLIP-seq
MIRT2149600	hsa-miR-1913	CLIP-seq
MIRT1496745	hsa-miR-206	CLIP-seq
MIRT2149601	hsa-miR-2278	CLIP-seq
MIRT2149602	hsa-miR-3074-5p	CLIP-seq
MIRT2149603	hsa-miR-3160-3p	CLIP-seq
MIRT2149604	hsa-miR-3167	CLIP-seq
MIRT1496746	hsa-miR-3189-3p	CLIP-seq
MIRT1496747	hsa-miR-3189-5p	CLIP-seq
MIRT1496748	hsa-miR-3192	CLIP-seq
MIRT2149605	hsa-miR-324-3p	CLIP-seq
MIRT2149606	hsa-miR-329	CLIP-seq
MIRT2149607	hsa-miR-362-3p	CLIP-seq
MIRT1496749	hsa-miR-3652	CLIP-seq
MIRT1496750	hsa-miR-3663-5p	CLIP-seq
MIRT1496751	hsa-miR-3673	CLIP-seq
MIRT1496752	hsa-miR-3922-5p	CLIP-seq
MIRT1496754	hsa-miR-4327	CLIP-seq
MIRT1496755	hsa-miR-4430	CLIP-seq
MIRT1496756	hsa-miR-4434	CLIP-seq
MIRT1496757	hsa-miR-4440	CLIP-seq
MIRT2149608	hsa-miR-4487	CLIP-seq
MIRT1496758	hsa-miR-4505	CLIP-seq
MIRT1496759	hsa-miR-4516	CLIP-seq
MIRT1496760	hsa-miR-4527	CLIP-seq
MIRT1496761	hsa-miR-4640-5p	CLIP-seq
MIRT1496764	hsa-miR-4726-5p	CLIP-seq
MIRT2149609	hsa-miR-4727-5p	CLIP-seq
MIRT1496765	hsa-miR-4746-3p	CLIP-seq
MIRT2149610	hsa-miR-4758-3p	CLIP-seq
MIRT1496766	hsa-miR-4786-3p	CLIP-seq
MIRT1496767	hsa-miR-4790-3p	CLIP-seq
MIRT2149611	hsa-miR-539	CLIP-seq
MIRT2149612	hsa-miR-558	CLIP-seq
MIRT1496769	hsa-miR-574-5p	CLIP-seq
MIRT1496770	hsa-miR-613	CLIP-seq
MIRT1496771	hsa-miR-647	CLIP-seq
MIRT2149613	hsa-miR-663	CLIP-seq
MIRT2149614	hsa-miR-876-5p	CLIP-seq
MIRT1496742	hsa-miR-1	CLIP-seq
MIRT2149595	hsa-miR-1272	CLIP-seq
MIRT2149598	hsa-miR-182	CLIP-seq
MIRT2149600	hsa-miR-1913	CLIP-seq
MIRT1496745	hsa-miR-206	CLIP-seq
MIRT1496746	hsa-miR-3189-3p	CLIP-seq
MIRT1496747	hsa-miR-3189-5p	CLIP-seq
MIRT2149605	hsa-miR-324-3p	CLIP-seq
MIRT1496751	hsa-miR-3673	CLIP-seq
MIRT2149609	hsa-miR-4727-5p	CLIP-seq
MIRT2149610	hsa-miR-4758-3p	CLIP-seq
MIRT1496770	hsa-miR-613	CLIP-seq
MIRT2397101	hsa-miR-1912	CLIP-seq
MIRT2397102	hsa-miR-3194-3p	CLIP-seq
MIRT1496750	hsa-miR-3663-5p	CLIP-seq
MIRT2397103	hsa-miR-4267	CLIP-seq
MIRT1496760	hsa-miR-4527	CLIP-seq
MIRT1496761	hsa-miR-4640-5p	CLIP-seq
MIRT1496764	hsa-miR-4726-5p	CLIP-seq
MIRT1496766	hsa-miR-4786-3p	CLIP-seq
MIRT2397104	hsa-miR-4800-5p	CLIP-seq
MIRT2397105	hsa-miR-711	CLIP-seq
MIRT2149598	hsa-miR-182	CLIP-seq
MIRT2149600	hsa-miR-1913	CLIP-seq
MIRT2149603	hsa-miR-3160-3p	CLIP-seq
MIRT1496746	hsa-miR-3189-3p	CLIP-seq
MIRT1496747	hsa-miR-3189-5p	CLIP-seq
MIRT2149605	hsa-miR-324-3p	CLIP-seq
MIRT1496757	hsa-miR-4440	CLIP-seq
MIRT2149608	hsa-miR-4487	CLIP-seq
MIRT2149609	hsa-miR-4727-5p	CLIP-seq
MIRT2149610	hsa-miR-4758-3p	CLIP-seq
MIRT2149612	hsa-miR-558	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005049	Function	Nuclear export signal receptor activity	IDA	14592989
GO:0005049	Function	Nuclear export signal receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	14592989, 16189514, 21516116, 25416956, 29892012
GO:0005634	Component	Nucleus	IC	14592989
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IC	14592989
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006611	Process	Protein export from nucleus	IBA
GO:0006611	Process	Protein export from nucleus	IDA	14592989
GO:0006611	Process	Protein export from nucleus	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0015031	Process	Protein transport	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0032991	Component	Protein-containing complex	IDA	28246125

Other IDs

• MIM: 608411
• HGNC: 19733
• e!Ensembl: ENSG00000169180

Protein

• UniProt ID: Q96QU8
• Protein name: Exportin-6 (Exp6) (Ran-binding protein 20)
• Protein function: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03810	IBN_N	31 → 97	Importin-beta N-terminal domain	Family
  PF08389	Xpo1	103 → 284	Exportin 1-like protein	Family

• Sequence:

  MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYV
  MMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQ
  DWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQV
  QTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDV
  ESEYICSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDIRARKMASVNGSSQNCV
  SGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRL
  EELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLTLLFKYTFHQPTHEGYFSCLDI
  WTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDD
  DQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGSGHRLN
  ITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTVVERLVKVTLYGSQI
  KLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSEVHRQNTQQFVTLISTTMDA
  ITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNRITDASALRLVDKAQV
  LVCRALSNILLLPWPNLPENEQQWPVRSINHASLISALSRDYRNLKPSAVAPQRKMPLDD
  TKLIIHQTLSVLEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLS
  FFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVV
  QEPGQVFKPFLPSIIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLA
  SVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRT
  AMLFQFVNVLLQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQ
  KSVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL

• Sequence length: 1125

Pathways

KEGG Pathway:

Nucleocytoplasmic transport

Related Genes

No strongly related genes found yet for XPO6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to XPO6.