XKR8 (XK related 8)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55113
• Gene name: XK related 8
• Gene symbol: XKR8
• Synonyms (NCBI Gene): XRG8, hXkr8
• Chromosome: 1
• Chromosome location: 1p35.3

miRNA Show/Hide all (160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031430	hsa-miR-16-5p	Microarray	21199864
MIRT1495922	hsa-miR-1208	CLIP-seq
MIRT1495923	hsa-miR-1238	CLIP-seq
MIRT1495924	hsa-miR-124	CLIP-seq
MIRT1495925	hsa-miR-129-3p	CLIP-seq
MIRT1495926	hsa-miR-150	CLIP-seq
MIRT1495927	hsa-miR-196a	CLIP-seq
MIRT1495928	hsa-miR-196b	CLIP-seq
MIRT1495929	hsa-miR-219-2-3p	CLIP-seq
MIRT1495930	hsa-miR-2964a-3p	CLIP-seq
MIRT1495931	hsa-miR-3124-3p	CLIP-seq
MIRT1495932	hsa-miR-3199	CLIP-seq
MIRT1495933	hsa-miR-3650	CLIP-seq
MIRT1495934	hsa-miR-3714	CLIP-seq
MIRT1495935	hsa-miR-3910	CLIP-seq
MIRT1495936	hsa-miR-3918	CLIP-seq
MIRT1495937	hsa-miR-4266	CLIP-seq
MIRT1495938	hsa-miR-433	CLIP-seq
MIRT1495939	hsa-miR-4420	CLIP-seq
MIRT1495940	hsa-miR-450b-3p	CLIP-seq
MIRT1495941	hsa-miR-4515	CLIP-seq
MIRT1495942	hsa-miR-4685-5p	CLIP-seq
MIRT1495943	hsa-miR-4691-5p	CLIP-seq
MIRT1495944	hsa-miR-4695-5p	CLIP-seq
MIRT1495945	hsa-miR-4713-3p	CLIP-seq
MIRT1495946	hsa-miR-4778-3p	CLIP-seq
MIRT1495947	hsa-miR-4779	CLIP-seq
MIRT1495948	hsa-miR-4790-3p	CLIP-seq
MIRT1495949	hsa-miR-4794	CLIP-seq
MIRT1495950	hsa-miR-506	CLIP-seq
MIRT1495951	hsa-miR-520g	CLIP-seq
MIRT1495952	hsa-miR-520h	CLIP-seq
MIRT1495953	hsa-miR-548m	CLIP-seq
MIRT1495954	hsa-miR-562	CLIP-seq
MIRT1495955	hsa-miR-638	CLIP-seq
MIRT1495956	hsa-miR-769-3p	CLIP-seq
MIRT1495957	hsa-miR-892b	CLIP-seq
MIRT1555609	hsa-let-7a	CLIP-seq
MIRT1555610	hsa-let-7b	CLIP-seq
MIRT1555611	hsa-let-7c	CLIP-seq
MIRT1555612	hsa-let-7d	CLIP-seq
MIRT1555613	hsa-let-7e	CLIP-seq
MIRT1555614	hsa-let-7f	CLIP-seq
MIRT1555615	hsa-let-7g	CLIP-seq
MIRT1555616	hsa-let-7i	CLIP-seq
MIRT1495924	hsa-miR-124	CLIP-seq
MIRT1555617	hsa-miR-151-3p	CLIP-seq
MIRT1555618	hsa-miR-202	CLIP-seq
MIRT1495934	hsa-miR-3714	CLIP-seq
MIRT1495935	hsa-miR-3910	CLIP-seq
MIRT1495937	hsa-miR-4266	CLIP-seq
MIRT1555619	hsa-miR-4458	CLIP-seq
MIRT1555620	hsa-miR-4463	CLIP-seq
MIRT1555621	hsa-miR-4499	CLIP-seq
MIRT1555622	hsa-miR-4500	CLIP-seq
MIRT1495944	hsa-miR-4695-5p	CLIP-seq
MIRT1495947	hsa-miR-4779	CLIP-seq
MIRT1495949	hsa-miR-4794	CLIP-seq
MIRT1495950	hsa-miR-506	CLIP-seq
MIRT1495957	hsa-miR-892b	CLIP-seq
MIRT1555623	hsa-miR-98	CLIP-seq
MIRT2149329	hsa-miR-1179	CLIP-seq
MIRT1495922	hsa-miR-1208	CLIP-seq
MIRT2149330	hsa-miR-1226	CLIP-seq
MIRT2149331	hsa-miR-182	CLIP-seq
MIRT1495929	hsa-miR-219-2-3p	CLIP-seq
MIRT1495930	hsa-miR-2964a-3p	CLIP-seq
MIRT1495931	hsa-miR-3124-3p	CLIP-seq
MIRT2149332	hsa-miR-3147	CLIP-seq
MIRT2149333	hsa-miR-3151	CLIP-seq
MIRT2149334	hsa-miR-3945	CLIP-seq
MIRT2149335	hsa-miR-4253	CLIP-seq
MIRT2149336	hsa-miR-4260	CLIP-seq
MIRT1495938	hsa-miR-433	CLIP-seq
MIRT1495939	hsa-miR-4420	CLIP-seq
MIRT2149337	hsa-miR-4470	CLIP-seq
MIRT2149338	hsa-miR-4680-5p	CLIP-seq
MIRT1495946	hsa-miR-4778-3p	CLIP-seq
MIRT1495948	hsa-miR-4790-3p	CLIP-seq
MIRT2149339	hsa-miR-486-3p	CLIP-seq
MIRT1555609	hsa-let-7a	CLIP-seq
MIRT1555610	hsa-let-7b	CLIP-seq
MIRT1555611	hsa-let-7c	CLIP-seq
MIRT1555612	hsa-let-7d	CLIP-seq
MIRT1555613	hsa-let-7e	CLIP-seq
MIRT1555614	hsa-let-7f	CLIP-seq
MIRT1555615	hsa-let-7g	CLIP-seq
MIRT1555616	hsa-let-7i	CLIP-seq
MIRT1495922	hsa-miR-1208	CLIP-seq
MIRT2149330	hsa-miR-1226	CLIP-seq
MIRT2369778	hsa-miR-1236	CLIP-seq
MIRT2369779	hsa-miR-1267	CLIP-seq
MIRT1555617	hsa-miR-151-3p	CLIP-seq
MIRT2369780	hsa-miR-1972	CLIP-seq
MIRT2369781	hsa-miR-200b	CLIP-seq
MIRT2369782	hsa-miR-200c	CLIP-seq
MIRT1555618	hsa-miR-202	CLIP-seq
MIRT2369783	hsa-miR-3155	CLIP-seq
MIRT2369784	hsa-miR-3155b	CLIP-seq
MIRT2369785	hsa-miR-3183	CLIP-seq
MIRT2369786	hsa-miR-3190	CLIP-seq
MIRT2369787	hsa-miR-342-3p	CLIP-seq
MIRT2369788	hsa-miR-3614-5p	CLIP-seq
MIRT2369789	hsa-miR-3674	CLIP-seq
MIRT2369790	hsa-miR-369-3p	CLIP-seq
MIRT2369791	hsa-miR-376c	CLIP-seq
MIRT2149336	hsa-miR-4260	CLIP-seq
MIRT1495937	hsa-miR-4266	CLIP-seq
MIRT2369792	hsa-miR-4269	CLIP-seq
MIRT2369793	hsa-miR-4284	CLIP-seq
MIRT2369794	hsa-miR-429	CLIP-seq
MIRT1495939	hsa-miR-4420	CLIP-seq
MIRT2369795	hsa-miR-4457	CLIP-seq
MIRT1555619	hsa-miR-4458	CLIP-seq
MIRT1555620	hsa-miR-4463	CLIP-seq
MIRT1555621	hsa-miR-4499	CLIP-seq
MIRT1555622	hsa-miR-4500	CLIP-seq
MIRT2369796	hsa-miR-452	CLIP-seq
MIRT2369797	hsa-miR-4676-3p	CLIP-seq
MIRT2149338	hsa-miR-4680-5p	CLIP-seq
MIRT1495944	hsa-miR-4695-5p	CLIP-seq
MIRT2369798	hsa-miR-4708-3p	CLIP-seq
MIRT2369799	hsa-miR-4723-3p	CLIP-seq
MIRT2369800	hsa-miR-4732-5p	CLIP-seq
MIRT2369801	hsa-miR-4753-3p	CLIP-seq
MIRT2369802	hsa-miR-4755-3p	CLIP-seq
MIRT1495947	hsa-miR-4779	CLIP-seq
MIRT1495949	hsa-miR-4794	CLIP-seq
MIRT2369803	hsa-miR-484	CLIP-seq
MIRT2149339	hsa-miR-486-3p	CLIP-seq
MIRT2369804	hsa-miR-513b	CLIP-seq
MIRT2369805	hsa-miR-563	CLIP-seq
MIRT2369806	hsa-miR-653	CLIP-seq
MIRT2369807	hsa-miR-664	CLIP-seq
MIRT2369808	hsa-miR-668	CLIP-seq
MIRT1495957	hsa-miR-892b	CLIP-seq
MIRT1555623	hsa-miR-98	CLIP-seq
MIRT2463599	hsa-miR-2467-5p	CLIP-seq
MIRT2463600	hsa-miR-3167	CLIP-seq
MIRT2463601	hsa-miR-3188	CLIP-seq
MIRT2463602	hsa-miR-3975	CLIP-seq
MIRT1495938	hsa-miR-433	CLIP-seq
MIRT2463603	hsa-miR-485-5p	CLIP-seq
MIRT2463604	hsa-miR-876-5p	CLIP-seq
MIRT2663389	hsa-miR-1912	CLIP-seq
MIRT2149332	hsa-miR-3147	CLIP-seq
MIRT2149334	hsa-miR-3945	CLIP-seq
MIRT2149335	hsa-miR-4253	CLIP-seq
MIRT2663390	hsa-miR-4259	CLIP-seq
MIRT2663391	hsa-miR-4757-5p	CLIP-seq
MIRT2663392	hsa-miR-571	CLIP-seq
MIRT2663393	hsa-miR-663b	CLIP-seq
MIRT2663389	hsa-miR-1912	CLIP-seq
MIRT2149332	hsa-miR-3147	CLIP-seq
MIRT2149334	hsa-miR-3945	CLIP-seq
MIRT2149335	hsa-miR-4253	CLIP-seq
MIRT2663390	hsa-miR-4259	CLIP-seq
MIRT2663391	hsa-miR-4757-5p	CLIP-seq
MIRT2663392	hsa-miR-571	CLIP-seq
MIRT2663393	hsa-miR-663b	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002513	Process	Tolerance induction to self antigen	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	23845944
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0017128	Function	Phospholipid scramblase activity	IDA	23845944
GO:0017128	Function	Phospholipid scramblase activity	ISS
GO:0043652	Process	Engulfment of apoptotic cell	IBA
GO:0043652	Process	Engulfment of apoptotic cell	IDA	23845944
GO:0043652	Process	Engulfment of apoptotic cell	IEA
GO:0045663	Process	Positive regulation of myoblast differentiation	IDA	28881496
GO:0045663	Process	Positive regulation of myoblast differentiation	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051649	Process	Establishment of localization in cell	IEA
GO:0070782	Process	Phosphatidylserine exposure on apoptotic cell surface	IBA
GO:0070782	Process	Phosphatidylserine exposure on apoptotic cell surface	IDA	23845944
GO:0070782	Process	Phosphatidylserine exposure on apoptotic cell surface	IEA
GO:0070782	Process	Phosphatidylserine exposure on apoptotic cell surface	ISS
GO:0097350	Process	Neutrophil clearance	IEA
GO:0097350	Process	Neutrophil clearance	ISS
GO:1902742	Process	Apoptotic process involved in development	IBA

Other IDs

• MIM: 619940
• HGNC: 25508
• e!Ensembl: ENSG00000158156

Protein

• UniProt ID: Q9H6D3
• Protein name: XK-related protein 8 (hXkr8) [Cleaved into: XK-related protein 8, processed form]
• Protein function: [XK-related protein 8, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:25231987). Phosphatidylserine is a specific marker only present at the surface of apopto
• PDB: 7DCE , 8XEJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09815	XK-related	14 → 344	XK-related protein	Family

• Sequence:

  MPWSSRGALLRDLVLGVLGTAAFLLDLGTDLWAAVQYALGGRYLWAALVLALLGLASVAL
  QLFSWLWLRADPAGLHGSQPPRRCLALLHLLQLGYLYRCVQELRQGLLVWQQEEPSEFDL
  AYADFLALDISMLRLFETFLETAPQLTLVLAIMLQSGRAEYYQWVGICTSFLGISWALLD
  YHRALRTCLPSKPLLGLGSSVIYFLWNLLLLWPRVLAVALFSALFPSYVALHFLGLWLVL
  LLWVWLQGTDFMPDPSSEWLYRVTVATILYFSWFNVAEGRTRGRAIIHFAFLLSDSILLV
  ATWVTHSSWLPSGIPLQLWLPVGCGCFFLGLALRLVYYHWLHPSCCWKPDPDQVDGARSL
  LSPEGYQLPQNRRMTHLAQKFFPKAKDEAASPVKG

• Sequence length: 395

Pathways

KEGG Pathway:

Efferocytosis

Related Genes

No strongly related genes found yet for XKR8.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to XKR8.