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Gene Gene information from NCBI Gene database.
Entrez ID 26118
Gene name WD repeat and SOCS box containing 1
Gene symbol WSB1
Synonyms (NCBI Gene)
SWIP1WSB-1
Chromosome 17
Chromosome location 17q11.1
Summary This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcri
miRNA miRNA information provided by mirtarbase database.
699 Show/Hide all (699)
miRTarBase ID miRNA Experiments Reference
MIRT697635 hsa-miR-302f HITS-CLIP 23313552
MIRT697634 hsa-miR-6808-5p HITS-CLIP 23313552
MIRT697633 hsa-miR-6893-5p HITS-CLIP 23313552
MIRT697632 hsa-miR-940 HITS-CLIP 23313552
MIRT697631 hsa-miR-3929 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9 Show/Hide all (9)
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IBA
GO:0005515 Function Protein binding IPI 18093972, 27273569, 32814053
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol TAS
GO:0016567 Process Protein ubiquitination IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610091 19221 ENSG00000109046
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y6I7
Protein name WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1)
Protein function Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronin
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 246 → 284 WD domain, G-beta repeat Repeat
PF00400 WD40 160 → 199 WD domain, G-beta repeat Repeat
PF00400 WD40 204 → 242 WD domain, G-beta repeat Repeat
PF00400 WD40 350 → 378 WD domain, G-beta repeat Repeat
PF00400 WD40 292 → 339 WD domain, G-beta repeat Repeat
PF07525 SOCS_box 384 → 419 SOCS box Domain
Sequence
MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL
VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP
EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP
DGSLILVSASRDKTLRVWD
LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL
WN
MDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP
PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR
IDEDYPVQVAPLSNGLCCAFS
TDGSVLAAGTHDGSVYFW
ATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR
I
Sequence length 421
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation