WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 124857
• Gene name: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
• Gene symbol: WFIKKN2
• Synonyms (NCBI Gene): GASP-1, WFDC20B, WFIKKNRP, hGASP-1
• Chromosome: 17
• Chromosome location: 17q21.33
• Summary: The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, fo

miRNA Show/Hide all (73)

miRTarBase ID	miRNA	Experiments	Reference
MIRT459076	hsa-miR-3200-5p	PAR-CLIP	23592263
MIRT459075	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT459074	hsa-miR-4784	PAR-CLIP	23592263
MIRT459073	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT459072	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT459071	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT459070	hsa-miR-5194	PAR-CLIP	23592263
MIRT459069	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT459068	hsa-miR-765	PAR-CLIP	23592263
MIRT459067	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT459066	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT459065	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT459064	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT459062	hsa-miR-6762-5p	PAR-CLIP	23592263
MIRT459063	hsa-miR-6845-5p	PAR-CLIP	23592263
MIRT459061	hsa-miR-128-1-5p	PAR-CLIP	23592263
MIRT459060	hsa-miR-128-2-5p	PAR-CLIP	23592263
MIRT459059	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT459058	hsa-miR-1227-5p	PAR-CLIP	23592263
MIRT459076	hsa-miR-3200-5p	PAR-CLIP	23592263
MIRT459075	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT459074	hsa-miR-4784	PAR-CLIP	23592263
MIRT459073	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT459072	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT459071	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT459070	hsa-miR-5194	PAR-CLIP	23592263
MIRT459069	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT459068	hsa-miR-765	PAR-CLIP	23592263
MIRT459067	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT459066	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT459065	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT459064	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT459062	hsa-miR-6762-5p	PAR-CLIP	23592263
MIRT459063	hsa-miR-6845-5p	PAR-CLIP	23592263
MIRT459061	hsa-miR-128-1-5p	PAR-CLIP	23592263
MIRT459060	hsa-miR-128-2-5p	PAR-CLIP	23592263
MIRT459059	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT459058	hsa-miR-1227-5p	PAR-CLIP	23592263
MIRT1492374	hsa-miR-1324	CLIP-seq
MIRT1492375	hsa-miR-508-5p	CLIP-seq
MIRT2148451	hsa-miR-2467-3p	CLIP-seq
MIRT2148452	hsa-miR-3160-3p	CLIP-seq
MIRT2148453	hsa-miR-3170	CLIP-seq
MIRT2148454	hsa-miR-3660	CLIP-seq
MIRT2148455	hsa-miR-3678-3p	CLIP-seq
MIRT2148456	hsa-miR-370	CLIP-seq
MIRT2148457	hsa-miR-4446-5p	CLIP-seq
MIRT2148458	hsa-miR-4447	CLIP-seq
MIRT2148459	hsa-miR-4472	CLIP-seq
MIRT2148460	hsa-miR-4526	CLIP-seq
MIRT2148461	hsa-miR-4645-3p	CLIP-seq
MIRT2148462	hsa-miR-4755-5p	CLIP-seq
MIRT2148463	hsa-miR-626	CLIP-seq
MIRT2148464	hsa-miR-670	CLIP-seq
MIRT2368872	hsa-miR-2115	CLIP-seq
MIRT2368873	hsa-miR-214	CLIP-seq
MIRT2368874	hsa-miR-3121-5p	CLIP-seq
MIRT2368875	hsa-miR-3127-5p	CLIP-seq
MIRT2368876	hsa-miR-342-3p	CLIP-seq
MIRT2368877	hsa-miR-3619-5p	CLIP-seq
MIRT2368878	hsa-miR-3918	CLIP-seq
MIRT2368879	hsa-miR-4291	CLIP-seq
MIRT2368880	hsa-miR-4453	CLIP-seq
MIRT2368881	hsa-miR-4488	CLIP-seq
MIRT2368882	hsa-miR-4538	CLIP-seq
MIRT2368883	hsa-miR-4697-5p	CLIP-seq
MIRT2368884	hsa-miR-4719	CLIP-seq
MIRT2368885	hsa-miR-4726-3p	CLIP-seq
MIRT2368886	hsa-miR-486-3p	CLIP-seq
MIRT2368887	hsa-miR-646	CLIP-seq
MIRT2368888	hsa-miR-761	CLIP-seq
MIRT2368889	hsa-miR-922	CLIP-seq
MIRT1492374	hsa-miR-1324	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IEA
GO:0004857	Function	Enzyme inhibitor activity	IEA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	18596030
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	12595574
GO:0005615	Component	Extracellular space	IEA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IBA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IEA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	ISS	12595574
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IDA	21054789
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0048019	Function	Receptor antagonist activity	IBA
GO:0048019	Function	Receptor antagonist activity	IDA	21054789
GO:0048019	Function	Receptor antagonist activity	IEA
GO:0050431	Function	Transforming growth factor beta binding	IBA
GO:0050431	Function	Transforming growth factor beta binding	IDA	21054789
GO:0050431	Function	Transforming growth factor beta binding	IEA
GO:0050431	Function	Transforming growth factor beta binding	IPI	12595574
GO:0055001	Process	Muscle cell development	IEA
GO:0060021	Process	Roof of mouth development	IEA

Other IDs

• MIM: 610895
• HGNC: 30916
• e!Ensembl: ENSG00000173714

Protein

• UniProt ID: Q8TEU8
• Protein name: WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 (Growth and differentiation factor-associated serum protein 1) (GASP-1) (hGASP-1) (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein) (WFIKKN-related p
• Protein function: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity). {ECO:0000
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00014	Kunitz_BPTI	385 → 437	Kunitz/Bovine pancreatic trypsin inhibitor domain	Domain
  PF00014	Kunitz_BPTI	327 → 379	Kunitz/Bovine pancreatic trypsin inhibitor domain	Domain
  PF00095	WAP	42 → 91		Domain
  PF01759	NTR	456 → 562	UNC-6/NTR/C345C module	Domain
  PF07679	I-set	210 → 304	Immunoglobulin I-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney. {ECO:0000269|PubMed:11928817}.
• Sequence:

  MWAPRCRRFWSRWEQVAALLLLLLLLGVPPRSLALPPIRYSHAGICPNDMNPNLWVDAQS
  TCRRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQG
  SECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFT
  WPNTSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPE
  ITWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADF
  PLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGH
  CHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCE
  GNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDSGR
  ALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAML
  RPDSFVGASSARRVRKLREVMHKKTCDVLKEFLGLH

• Sequence length: 576

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
DIVERTICULAR DISEASE	—	GWAS catalog	30177863	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for WFIKKN2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to WFIKKN2.