WFDC8 (WAP four-disulfide core domain 8)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 90199
• Gene name: WAP four-disulfide core domain 8
• Gene symbol: WFDC8
• Synonyms (NCBI Gene): C20orf170, HEL-S-292, WAP8, dJ461P17.1
• Chromosome: 20
• Chromosome location: 20q13.12
• Summary: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The enco

miRNA Show/Hide all (103)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1492348	hsa-miR-1224-3p	CLIP-seq
MIRT1492349	hsa-miR-1260	CLIP-seq
MIRT1492350	hsa-miR-1260b	CLIP-seq
MIRT1492351	hsa-miR-128	CLIP-seq
MIRT1492352	hsa-miR-1280	CLIP-seq
MIRT1492353	hsa-miR-1293	CLIP-seq
MIRT1492354	hsa-miR-199a-3p	CLIP-seq
MIRT1492355	hsa-miR-199b-3p	CLIP-seq
MIRT1492356	hsa-miR-3129-5p	CLIP-seq
MIRT1492357	hsa-miR-3165	CLIP-seq
MIRT1492358	hsa-miR-34b	CLIP-seq
MIRT1492359	hsa-miR-3622a-3p	CLIP-seq
MIRT1492360	hsa-miR-3622b-3p	CLIP-seq
MIRT1492361	hsa-miR-4269	CLIP-seq
MIRT1492362	hsa-miR-4433	CLIP-seq
MIRT1492363	hsa-miR-4435	CLIP-seq
MIRT1492364	hsa-miR-4459	CLIP-seq
MIRT1492365	hsa-miR-4483	CLIP-seq
MIRT1492366	hsa-miR-4645-5p	CLIP-seq
MIRT1492367	hsa-miR-4673	CLIP-seq
MIRT1492368	hsa-miR-4694-3p	CLIP-seq
MIRT1492369	hsa-miR-4755-3p	CLIP-seq
MIRT1492370	hsa-miR-522	CLIP-seq
MIRT1492371	hsa-miR-532-3p	CLIP-seq
MIRT1492372	hsa-miR-544b	CLIP-seq
MIRT1492373	hsa-miR-936	CLIP-seq
MIRT2148443	hsa-miR-1285	CLIP-seq
MIRT2148444	hsa-miR-3187-5p	CLIP-seq
MIRT1492358	hsa-miR-34b	CLIP-seq
MIRT2148445	hsa-miR-3613-3p	CLIP-seq
MIRT2148446	hsa-miR-3945	CLIP-seq
MIRT2148447	hsa-miR-4253	CLIP-seq
MIRT2148448	hsa-miR-541	CLIP-seq
MIRT2148449	hsa-miR-612	CLIP-seq
MIRT2148450	hsa-miR-654-5p	CLIP-seq
MIRT1492348	hsa-miR-1224-3p	CLIP-seq
MIRT1492349	hsa-miR-1260	CLIP-seq
MIRT1492350	hsa-miR-1260b	CLIP-seq
MIRT1492351	hsa-miR-128	CLIP-seq
MIRT1492352	hsa-miR-1280	CLIP-seq
MIRT1492358	hsa-miR-34b	CLIP-seq
MIRT2368870	hsa-miR-4679	CLIP-seq
MIRT1492371	hsa-miR-532-3p	CLIP-seq
MIRT2148448	hsa-miR-541	CLIP-seq
MIRT2148450	hsa-miR-654-5p	CLIP-seq
MIRT2368871	hsa-miR-890	CLIP-seq
MIRT1492358	hsa-miR-34b	CLIP-seq
MIRT2148443	hsa-miR-1285	CLIP-seq
MIRT2148444	hsa-miR-3187-5p	CLIP-seq
MIRT2148445	hsa-miR-3613-3p	CLIP-seq
MIRT2463489	hsa-miR-3675-3p	CLIP-seq
MIRT2148446	hsa-miR-3945	CLIP-seq
MIRT2148447	hsa-miR-4253	CLIP-seq
MIRT2463490	hsa-miR-4684-5p	CLIP-seq
MIRT2148448	hsa-miR-541	CLIP-seq
MIRT2463491	hsa-miR-548aa	CLIP-seq
MIRT2463492	hsa-miR-548c-3p	CLIP-seq
MIRT2148449	hsa-miR-612	CLIP-seq
MIRT2148450	hsa-miR-654-5p	CLIP-seq
MIRT2368871	hsa-miR-890	CLIP-seq
MIRT2148443	hsa-miR-1285	CLIP-seq
MIRT2148444	hsa-miR-3187-5p	CLIP-seq
MIRT2148445	hsa-miR-3613-3p	CLIP-seq
MIRT2463489	hsa-miR-3675-3p	CLIP-seq
MIRT2148446	hsa-miR-3945	CLIP-seq
MIRT2148447	hsa-miR-4253	CLIP-seq
MIRT2463490	hsa-miR-4684-5p	CLIP-seq
MIRT2463491	hsa-miR-548aa	CLIP-seq
MIRT2463492	hsa-miR-548c-3p	CLIP-seq
MIRT2148449	hsa-miR-612	CLIP-seq
MIRT1492348	hsa-miR-1224-3p	CLIP-seq
MIRT1492349	hsa-miR-1260	CLIP-seq
MIRT1492350	hsa-miR-1260b	CLIP-seq
MIRT1492352	hsa-miR-1280	CLIP-seq
MIRT2148443	hsa-miR-1285	CLIP-seq
MIRT2148444	hsa-miR-3187-5p	CLIP-seq
MIRT1492358	hsa-miR-34b	CLIP-seq
MIRT2148445	hsa-miR-3613-3p	CLIP-seq
MIRT2463489	hsa-miR-3675-3p	CLIP-seq
MIRT2148446	hsa-miR-3945	CLIP-seq
MIRT2148447	hsa-miR-4253	CLIP-seq
MIRT2368870	hsa-miR-4679	CLIP-seq
MIRT2463490	hsa-miR-4684-5p	CLIP-seq
MIRT2148448	hsa-miR-541	CLIP-seq
MIRT2463491	hsa-miR-548aa	CLIP-seq
MIRT2463492	hsa-miR-548c-3p	CLIP-seq
MIRT2148449	hsa-miR-612	CLIP-seq
MIRT2148450	hsa-miR-654-5p	CLIP-seq
MIRT2368871	hsa-miR-890	CLIP-seq
MIRT2148443	hsa-miR-1285	CLIP-seq
MIRT2148444	hsa-miR-3187-5p	CLIP-seq
MIRT1492358	hsa-miR-34b	CLIP-seq
MIRT2148445	hsa-miR-3613-3p	CLIP-seq
MIRT2463489	hsa-miR-3675-3p	CLIP-seq
MIRT2148446	hsa-miR-3945	CLIP-seq
MIRT2148447	hsa-miR-4253	CLIP-seq
MIRT2463490	hsa-miR-4684-5p	CLIP-seq
MIRT2148448	hsa-miR-541	CLIP-seq
MIRT2463491	hsa-miR-548aa	CLIP-seq
MIRT2463492	hsa-miR-548c-3p	CLIP-seq
MIRT2148449	hsa-miR-612	CLIP-seq
MIRT2148450	hsa-miR-654-5p	CLIP-seq
MIRT2368871	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0030414	Function	Peptidase inhibitor activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8IUA0
• Protein name: WAP four-disulfide core domain protein 8 (Putative protease inhibitor WAP8)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00014	Kunitz_BPTI	94 → 146	Kunitz/Bovine pancreatic trypsin inhibitor domain	Domain
  PF00095	WAP	47 → 90		Domain
  PF00095	WAP	150 → 193		Domain
  PF00095	WAP	197 → 239		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed ubiquitously, the highest levels are found in the epididymis followed by testis and trachea.
• Sequence:

  MWTVRTEGGHFPLHSPTFSWRNVAFLLLLSLALEWTSAMLTKKIKHKPGLCPKERLTCTT
  ELPDSCNTDFDCKEYQKCCFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRC
  TPFKYRGCEGNANNFLNEDACRTACMLIVKDGQCPLFPFTERKECPPSCHSDIDCPQTDK
  CCESRCGFVCARAWTVKKGFCPRKPLLCTKIDKPKCLQDEECPLVEKCCSHCGLKCMDPR
  R

• Sequence length: 241

Related Genes

No strongly related genes found yet for WFDC8.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to WFDC8.