WFDC6 (WAP four-disulfide core domain 6)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 140870
• Gene name: WAP four-disulfide core domain 6
• Gene symbol: WFDC6
• Synonyms (NCBI Gene): C20orf171, HEL-S-295, WAP6, dJ461P17.11
• Chromosome: 20
• Chromosome location: 20q13.12
• Summary: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFD

miRNA Show/Hide all (85)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029633	hsa-miR-26b-5p	Microarray	19088304
MIRT683259	hsa-miR-5571-5p	HITS-CLIP	23313552
MIRT683258	hsa-miR-4438	HITS-CLIP	23313552
MIRT683257	hsa-miR-1244	HITS-CLIP	23313552
MIRT683256	hsa-miR-4715-5p	HITS-CLIP	23313552
MIRT683255	hsa-miR-4259	HITS-CLIP	23313552
MIRT683254	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT683253	hsa-miR-4740-3p	HITS-CLIP	23313552
MIRT683252	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT683251	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT683250	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT683249	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT683248	hsa-miR-1976	HITS-CLIP	23313552
MIRT633203	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT683247	hsa-miR-4703-3p	HITS-CLIP	23313552
MIRT683246	hsa-miR-4425	HITS-CLIP	23313552
MIRT683245	hsa-miR-5095	HITS-CLIP	23313552
MIRT683244	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT683243	hsa-miR-6715b-3p	HITS-CLIP	23313552
MIRT683242	hsa-miR-4279	HITS-CLIP	23313552
MIRT683241	hsa-miR-450b-3p	HITS-CLIP	23313552
MIRT683240	hsa-miR-769-3p	HITS-CLIP	23313552
MIRT683239	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT683238	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT683237	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT683236	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT633213	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT633212	hsa-miR-764	HITS-CLIP	23824327
MIRT633211	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT633210	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT633209	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT633208	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT633207	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT633206	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT633204	hsa-miR-4454	HITS-CLIP	23824327
MIRT633205	hsa-miR-4290	HITS-CLIP	23824327
MIRT633203	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633202	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT633201	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT633200	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT683259	hsa-miR-5571-5p	HITS-CLIP	23313552
MIRT683258	hsa-miR-4438	HITS-CLIP	23313552
MIRT683257	hsa-miR-1244	HITS-CLIP	23313552
MIRT683256	hsa-miR-4715-5p	HITS-CLIP	23313552
MIRT683255	hsa-miR-4259	HITS-CLIP	23313552
MIRT683254	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT683253	hsa-miR-4740-3p	HITS-CLIP	23313552
MIRT683252	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT683251	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT683250	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT683249	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT683248	hsa-miR-1976	HITS-CLIP	23313552
MIRT633203	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT683247	hsa-miR-4703-3p	HITS-CLIP	23313552
MIRT683246	hsa-miR-4425	HITS-CLIP	23313552
MIRT683245	hsa-miR-5095	HITS-CLIP	23313552
MIRT683244	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT683243	hsa-miR-6715b-3p	HITS-CLIP	23313552
MIRT683242	hsa-miR-4279	HITS-CLIP	23313552
MIRT683241	hsa-miR-450b-3p	HITS-CLIP	23313552
MIRT683240	hsa-miR-769-3p	HITS-CLIP	23313552
MIRT683239	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT683238	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT683237	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT683236	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT633213	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT633212	hsa-miR-764	HITS-CLIP	23824327
MIRT633211	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT633210	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT633209	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT633208	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT633207	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT633206	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT633204	hsa-miR-4454	HITS-CLIP	23824327
MIRT633205	hsa-miR-4290	HITS-CLIP	23824327
MIRT633203	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633202	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT633201	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT633200	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT2148437	hsa-miR-1254	CLIP-seq
MIRT2148438	hsa-miR-185	CLIP-seq
MIRT2148439	hsa-miR-3116	CLIP-seq
MIRT2148440	hsa-miR-4306	CLIP-seq
MIRT2148441	hsa-miR-4644	CLIP-seq
MIRT2148442	hsa-miR-556-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0030414	Function	Peptidase inhibitor activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9BQY6
• Protein name: WAP four-disulfide core domain protein 6 (Putative protease inhibitor WAP6)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00014	Kunitz_BPTI	90 → 128	Kunitz/Bovine pancreatic trypsin inhibitor domain	Domain
  PF00095	WAP	31 → 72		Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed, but the highest levels are found in epididymis, testis and trachea.
• Sequence:

  MGLSGLLPILVPFILLGDIQEPGHAEGILGKPCPKIKVECEVEEIDQCTKPRDCPENMKC
  CPFSRGKKCLDFRKIYAVCHRRLAPAWPPYHTGGTIKKTKICSEFIYGGSQGNNNNFQTE
  AICLVTCKKYH

• Sequence length: 131

Related Genes

No strongly related genes found yet for WFDC6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to WFDC6.