WDR91 (WD repeat domain 91)

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Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 29062
• Gene name: WD repeat domain 91
• Gene symbol: WDR91
• Synonyms (NCBI Gene): HSPC049, SORF-1, SORF1
• Chromosome: 7
• Chromosome location: 7q33

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs373727223	C>A,T	Pathogenic	Missense variant, 5 prime UTR variant, coding sequence variant, genic upstream transcript variant, non coding transcript variant, stop gained

miRNA Show/Hide all (236)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028975	hsa-miR-26b-5p	Microarray	19088304
MIRT631644	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT631643	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT631642	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT631640	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT631641	hsa-miR-6131	HITS-CLIP	23313552
MIRT693867	hsa-miR-378a-5p	HITS-CLIP	23313552
MIRT631639	hsa-miR-513c-5p	HITS-CLIP	23313552
MIRT631638	hsa-miR-514b-5p	HITS-CLIP	23313552
MIRT631637	hsa-miR-548s	HITS-CLIP	23313552
MIRT631636	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT631635	hsa-miR-588	HITS-CLIP	23313552
MIRT631634	hsa-miR-4435	HITS-CLIP	23313552
MIRT631633	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT631632	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT631631	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT631644	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT631643	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631642	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT631640	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT631641	hsa-miR-6131	HITS-CLIP	23824327
MIRT631639	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT631638	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT631637	hsa-miR-548s	HITS-CLIP	23824327
MIRT631636	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT631635	hsa-miR-588	HITS-CLIP	23824327
MIRT631634	hsa-miR-4435	HITS-CLIP	23824327
MIRT631633	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT631632	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT631631	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT631644	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT631643	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT631642	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT631640	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT631641	hsa-miR-6131	HITS-CLIP	23313552
MIRT693867	hsa-miR-378a-5p	HITS-CLIP	23313552
MIRT631639	hsa-miR-513c-5p	HITS-CLIP	23313552
MIRT631638	hsa-miR-514b-5p	HITS-CLIP	23313552
MIRT631637	hsa-miR-548s	HITS-CLIP	23313552
MIRT631636	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT631635	hsa-miR-588	HITS-CLIP	23313552
MIRT631634	hsa-miR-4435	HITS-CLIP	23313552
MIRT631633	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT631632	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT631631	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT631644	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT631643	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631642	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT631640	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT631641	hsa-miR-6131	HITS-CLIP	23824327
MIRT631639	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT631638	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT631637	hsa-miR-548s	HITS-CLIP	23824327
MIRT631636	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT631635	hsa-miR-588	HITS-CLIP	23824327
MIRT631634	hsa-miR-4435	HITS-CLIP	23824327
MIRT631633	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT631632	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT631631	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT1492007	hsa-miR-1200	CLIP-seq
MIRT1492008	hsa-miR-1273d	CLIP-seq
MIRT1492009	hsa-miR-1281	CLIP-seq
MIRT1492010	hsa-miR-1293	CLIP-seq
MIRT1492011	hsa-miR-1307	CLIP-seq
MIRT1492012	hsa-miR-1323	CLIP-seq
MIRT1492013	hsa-miR-1343	CLIP-seq
MIRT1492014	hsa-miR-194	CLIP-seq
MIRT1492015	hsa-miR-2467-5p	CLIP-seq
MIRT1492016	hsa-miR-3127-5p	CLIP-seq
MIRT1492017	hsa-miR-3154	CLIP-seq
MIRT1492018	hsa-miR-3179	CLIP-seq
MIRT1492019	hsa-miR-3182	CLIP-seq
MIRT1492020	hsa-miR-3188	CLIP-seq
MIRT1492021	hsa-miR-3607-3p	CLIP-seq
MIRT1492022	hsa-miR-3622a-5p	CLIP-seq
MIRT1492023	hsa-miR-3686	CLIP-seq
MIRT1492024	hsa-miR-3689a-3p	CLIP-seq
MIRT1492025	hsa-miR-3689c	CLIP-seq
MIRT1492026	hsa-miR-378g	CLIP-seq
MIRT1492027	hsa-miR-3918	CLIP-seq
MIRT1492028	hsa-miR-3975	CLIP-seq
MIRT1492029	hsa-miR-4251	CLIP-seq
MIRT1492030	hsa-miR-4284	CLIP-seq
MIRT1492031	hsa-miR-4316	CLIP-seq
MIRT1492032	hsa-miR-4323	CLIP-seq
MIRT1492033	hsa-miR-4324	CLIP-seq
MIRT1492034	hsa-miR-4419a	CLIP-seq
MIRT1492035	hsa-miR-4423-3p	CLIP-seq
MIRT1492036	hsa-miR-4434	CLIP-seq
MIRT1492037	hsa-miR-4437	CLIP-seq
MIRT1492038	hsa-miR-4483	CLIP-seq
MIRT1492039	hsa-miR-4505	CLIP-seq
MIRT1492040	hsa-miR-4510	CLIP-seq
MIRT1492041	hsa-miR-4516	CLIP-seq
MIRT1492042	hsa-miR-4530	CLIP-seq
MIRT1492043	hsa-miR-4638-5p	CLIP-seq
MIRT1492044	hsa-miR-4640-5p	CLIP-seq
MIRT1492045	hsa-miR-4674	CLIP-seq
MIRT1492046	hsa-miR-4695-3p	CLIP-seq
MIRT1492047	hsa-miR-4715-3p	CLIP-seq
MIRT1492048	hsa-miR-4722-3p	CLIP-seq
MIRT1492049	hsa-miR-4726-5p	CLIP-seq
MIRT1492050	hsa-miR-4728-5p	CLIP-seq
MIRT1492051	hsa-miR-4772-3p	CLIP-seq
MIRT1492052	hsa-miR-4793-5p	CLIP-seq
MIRT1492053	hsa-miR-485-5p	CLIP-seq
MIRT1492054	hsa-miR-495	CLIP-seq
MIRT1492055	hsa-miR-544b	CLIP-seq
MIRT1492056	hsa-miR-548o	CLIP-seq
MIRT1492057	hsa-miR-580	CLIP-seq
MIRT1492058	hsa-miR-922	CLIP-seq
MIRT1492007	hsa-miR-1200	CLIP-seq
MIRT2148362	hsa-miR-1254	CLIP-seq
MIRT1492009	hsa-miR-1281	CLIP-seq
MIRT1492013	hsa-miR-1343	CLIP-seq
MIRT1492014	hsa-miR-194	CLIP-seq
MIRT2148363	hsa-miR-2467-3p	CLIP-seq
MIRT2148364	hsa-miR-3116	CLIP-seq
MIRT1492019	hsa-miR-3182	CLIP-seq
MIRT1492021	hsa-miR-3607-3p	CLIP-seq
MIRT1492023	hsa-miR-3686	CLIP-seq
MIRT1492026	hsa-miR-378g	CLIP-seq
MIRT1492029	hsa-miR-4251	CLIP-seq
MIRT1492033	hsa-miR-4324	CLIP-seq
MIRT1492037	hsa-miR-4437	CLIP-seq
MIRT1492045	hsa-miR-4674	CLIP-seq
MIRT1492048	hsa-miR-4722-3p	CLIP-seq
MIRT1492054	hsa-miR-495	CLIP-seq
MIRT1492055	hsa-miR-544b	CLIP-seq
MIRT1492057	hsa-miR-580	CLIP-seq
MIRT2368746	hsa-miR-1203	CLIP-seq
MIRT2368747	hsa-miR-1237	CLIP-seq
MIRT2368748	hsa-miR-1238	CLIP-seq
MIRT2368749	hsa-miR-1248	CLIP-seq
MIRT2148362	hsa-miR-1254	CLIP-seq
MIRT2368750	hsa-miR-1324	CLIP-seq
MIRT2368751	hsa-miR-185	CLIP-seq
MIRT2368752	hsa-miR-1912	CLIP-seq
MIRT2368753	hsa-miR-200b	CLIP-seq
MIRT2368754	hsa-miR-200c	CLIP-seq
MIRT2368755	hsa-miR-221	CLIP-seq
MIRT2368756	hsa-miR-222	CLIP-seq
MIRT2148364	hsa-miR-3116	CLIP-seq
MIRT2368757	hsa-miR-3124-3p	CLIP-seq
MIRT2368758	hsa-miR-3130-5p	CLIP-seq
MIRT2368759	hsa-miR-3144-5p	CLIP-seq
MIRT2368760	hsa-miR-3155	CLIP-seq
MIRT2368761	hsa-miR-3192	CLIP-seq
MIRT2368762	hsa-miR-326	CLIP-seq
MIRT2368763	hsa-miR-330-5p	CLIP-seq
MIRT2368764	hsa-miR-342-3p	CLIP-seq
MIRT2368765	hsa-miR-3913-3p	CLIP-seq
MIRT2368766	hsa-miR-410	CLIP-seq
MIRT2368767	hsa-miR-4254	CLIP-seq
MIRT2368768	hsa-miR-4277	CLIP-seq
MIRT2368769	hsa-miR-4279	CLIP-seq
MIRT2368770	hsa-miR-429	CLIP-seq
MIRT2368771	hsa-miR-4306	CLIP-seq
MIRT2368772	hsa-miR-4314	CLIP-seq
MIRT2368773	hsa-miR-4474-5p	CLIP-seq
MIRT2368774	hsa-miR-4482	CLIP-seq
MIRT1492042	hsa-miR-4530	CLIP-seq
MIRT2368775	hsa-miR-4644	CLIP-seq
MIRT2368776	hsa-miR-4646-5p	CLIP-seq
MIRT2368777	hsa-miR-4666-5p	CLIP-seq
MIRT2368778	hsa-miR-4691-3p	CLIP-seq
MIRT2368779	hsa-miR-4691-5p	CLIP-seq
MIRT1492048	hsa-miR-4722-3p	CLIP-seq
MIRT2368780	hsa-miR-4724-3p	CLIP-seq
MIRT2368781	hsa-miR-4747-5p	CLIP-seq
MIRT2368782	hsa-miR-4768-3p	CLIP-seq
MIRT2368783	hsa-miR-4773	CLIP-seq
MIRT2368784	hsa-miR-4778-3p	CLIP-seq
MIRT2368785	hsa-miR-548ag	CLIP-seq
MIRT2368786	hsa-miR-548ai	CLIP-seq
MIRT2368787	hsa-miR-568	CLIP-seq
MIRT2368788	hsa-miR-593	CLIP-seq
MIRT1492058	hsa-miR-922	CLIP-seq
MIRT2148362	hsa-miR-1254	CLIP-seq
MIRT2368751	hsa-miR-185	CLIP-seq
MIRT2148364	hsa-miR-3116	CLIP-seq
MIRT2368767	hsa-miR-4254	CLIP-seq
MIRT2368768	hsa-miR-4277	CLIP-seq
MIRT2368771	hsa-miR-4306	CLIP-seq
MIRT2368775	hsa-miR-4644	CLIP-seq
MIRT2368782	hsa-miR-4768-3p	CLIP-seq
MIRT1492016	hsa-miR-3127-5p	CLIP-seq
MIRT1492027	hsa-miR-3918	CLIP-seq
MIRT1492039	hsa-miR-4505	CLIP-seq
MIRT1492042	hsa-miR-4530	CLIP-seq
MIRT1492044	hsa-miR-4640-5p	CLIP-seq
MIRT1492049	hsa-miR-4726-5p	CLIP-seq
MIRT1492058	hsa-miR-922	CLIP-seq
MIRT2148362	hsa-miR-1254	CLIP-seq
MIRT2662319	hsa-miR-1273f	CLIP-seq
MIRT1492009	hsa-miR-1281	CLIP-seq
MIRT1492013	hsa-miR-1343	CLIP-seq
MIRT2662320	hsa-miR-197	CLIP-seq
MIRT2148364	hsa-miR-3116	CLIP-seq
MIRT2368759	hsa-miR-3144-5p	CLIP-seq
MIRT2662321	hsa-miR-3170	CLIP-seq
MIRT1492026	hsa-miR-378g	CLIP-seq
MIRT2368765	hsa-miR-3913-3p	CLIP-seq
MIRT2662322	hsa-miR-411	CLIP-seq
MIRT2662323	hsa-miR-4311	CLIP-seq
MIRT1492037	hsa-miR-4437	CLIP-seq
MIRT1492045	hsa-miR-4674	CLIP-seq
MIRT2368778	hsa-miR-4691-3p	CLIP-seq
MIRT1492047	hsa-miR-4715-3p	CLIP-seq
MIRT2662324	hsa-miR-4716-5p	CLIP-seq
MIRT1492048	hsa-miR-4722-3p	CLIP-seq
MIRT2662325	hsa-miR-4735-5p	CLIP-seq
MIRT2662326	hsa-miR-4753-3p	CLIP-seq
MIRT2662327	hsa-miR-4775	CLIP-seq
MIRT2662328	hsa-miR-4794	CLIP-seq
MIRT2662329	hsa-miR-496	CLIP-seq
MIRT2662330	hsa-miR-5096	CLIP-seq
MIRT2662331	hsa-miR-590-3p	CLIP-seq
MIRT2662332	hsa-miR-630	CLIP-seq
MIRT2662333	hsa-miR-661	CLIP-seq
MIRT2148362	hsa-miR-1254	CLIP-seq
MIRT2662319	hsa-miR-1273f	CLIP-seq
MIRT2662320	hsa-miR-197	CLIP-seq
MIRT2148364	hsa-miR-3116	CLIP-seq
MIRT2662321	hsa-miR-3170	CLIP-seq
MIRT2662322	hsa-miR-411	CLIP-seq
MIRT2368778	hsa-miR-4691-3p	CLIP-seq
MIRT1492047	hsa-miR-4715-3p	CLIP-seq
MIRT2662324	hsa-miR-4716-5p	CLIP-seq
MIRT1492048	hsa-miR-4722-3p	CLIP-seq
MIRT2662325	hsa-miR-4735-5p	CLIP-seq
MIRT2662327	hsa-miR-4775	CLIP-seq
MIRT2662328	hsa-miR-4794	CLIP-seq
MIRT2662330	hsa-miR-5096	CLIP-seq
MIRT2662331	hsa-miR-590-3p	CLIP-seq
MIRT2662333	hsa-miR-661	CLIP-seq

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17500595, 26783301, 27126989, 32814053
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IDA	26783301
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	28404643
GO:0010008	Component	Endosome membrane	IDA	26783301
GO:0016020	Component	Membrane	IEA
GO:0031901	Component	Early endosome membrane	IBA
GO:0031901	Component	Early endosome membrane	IDA	26783301
GO:0031901	Component	Early endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	IBA
GO:0031902	Component	Late endosome membrane	IDA	26783301, 28404643
GO:0031902	Component	Late endosome membrane	IEA
GO:0035014	Function	Phosphatidylinositol 3-kinase regulator activity	IBA
GO:0042176	Process	Regulation of protein catabolic process	IMP	27126989
GO:0045022	Process	Early endosome to late endosome transport	IBA
GO:0045022	Process	Early endosome to late endosome transport	IEA
GO:0045022	Process	Early endosome to late endosome transport	IMP	26783301, 27126989
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0141039	Function	Phosphatidylinositol 3-kinase inhibitor activity	IEA
GO:0141039	Function	Phosphatidylinositol 3-kinase inhibitor activity	IMP	26783301

Other IDs

• MIM: 616303
• HGNC: 24997
• e!Ensembl: ENSG00000105875

Protein

• UniProt ID: A4D1P6
• Protein name: WD repeat-containing protein 91
• Protein function: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may re
• PDB: 6VYC , 8KB8 , 8KB9 , 8SHJ , 8T55 , 9DTA , 9DTB , 9EJO , 9EJP , 9MK7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	552 → 590	WD domain, G-beta repeat	Repeat

• Sequence:

  MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAA
  LRDYWSYLERRLFSRLEDIYRPTIHKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQ
  NQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNFDA
  ECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQPEEEEALVQHKLPPYVSNMDRLGDS
  ELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQPQSSAKKESFGGQGTK
  GKDPTSGAKDGKSLLSGLATGESGWSQHRQRRLQDHGKERKELFSTTTSQCAEKKPEASG
  PEAEPCPELHTEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSG
  RRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDT
  EAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPG
  RLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSW
  RAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSG
  YKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWS
  TAMDCGTCLTASMDGKIKLTTLLAHKA

• Sequence length: 747

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Neurodevelopmental disorder with brain malformations and multiple congenital anomalies	Pathogenic	rs373727223	RCV001003466	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Related Genes

No strongly related genes found yet for WDR91.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to WDR91.