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Gene Gene information from NCBI Gene database.
Entrez ID 54853
Gene name WD repeat domain 55
Gene symbol WDR55
Synonyms (NCBI Gene)
-
Chromosome 5
Chromosome location 5q31.3
miRNA miRNA information provided by mirtarbase database.
545 Show/Hide all (545)
miRTarBase ID miRNA Experiments Reference
MIRT052095 hsa-let-7b-5p CLASH 23622248
MIRT665438 hsa-miR-5582-5p HITS-CLIP 23824327
MIRT665437 hsa-miR-128-3p HITS-CLIP 23824327
MIRT665436 hsa-miR-216a-3p HITS-CLIP 23824327
MIRT665435 hsa-miR-3681-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8 Show/Hide all (8)
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
GO:0005730 Component Nucleolus IDA
GO:0005730 Component Nucleolus IEA
GO:0005730 Component Nucleolus ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620832 25971 ENSG00000120314
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H6Y2
Protein name WD repeat-containing protein 55
Protein function Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).
PDB 7KQQ , 8FKY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 284 → 323 WD domain, G-beta repeat Repeat
PF12894 ANAPC4_WD40 44 → 138 Anaphase-promoting complex subunit 4 WD40 domain Repeat
Sequence
MDRTCEERPAEDGSDEEDPDSMEAPTRIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDG
DVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLER
RVSKAHGAPINSLLLVDE
NVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAK
KLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWN
GFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEE
LALSHCGRFLASSGHDQRLKFWD
MAQLRAVVVDDYRRRKKKGGPLRALSSKTWSTDDFFA
GLREEGEDSMAQEEKEETGDDSD
Sequence length 383
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Ovarian serous cystadenocarcinoma Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations