WDR47 (WD repeat domain 47)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 22911
• Gene name: WD repeat domain 47
• Gene symbol: WDR47
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p13.3

miRNA Show/Hide all (112)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024637	hsa-miR-215-5p	Microarray	19074876
MIRT026954	hsa-miR-192-5p	Microarray	19074876
MIRT1490768	hsa-miR-203	CLIP-seq
MIRT1490769	hsa-miR-217	CLIP-seq
MIRT1490770	hsa-miR-3140-3p	CLIP-seq
MIRT1490771	hsa-miR-3163	CLIP-seq
MIRT1490772	hsa-miR-3692	CLIP-seq
MIRT1490773	hsa-miR-4436b-5p	CLIP-seq
MIRT1490774	hsa-miR-4668-3p	CLIP-seq
MIRT1490775	hsa-miR-548c-3p	CLIP-seq
MIRT1490776	hsa-miR-576-5p	CLIP-seq
MIRT1490777	hsa-miR-935	CLIP-seq
MIRT1490778	hsa-miR-15a	CLIP-seq
MIRT1490779	hsa-miR-15b	CLIP-seq
MIRT1490780	hsa-miR-16	CLIP-seq
MIRT1490781	hsa-miR-195	CLIP-seq
MIRT1490782	hsa-miR-3173-3p	CLIP-seq
MIRT1490783	hsa-miR-338-5p	CLIP-seq
MIRT1490784	hsa-miR-3670	CLIP-seq
MIRT1490785	hsa-miR-3688-3p	CLIP-seq
MIRT1490786	hsa-miR-369-3p	CLIP-seq
MIRT1490787	hsa-miR-374c	CLIP-seq
MIRT1490788	hsa-miR-3941	CLIP-seq
MIRT1490789	hsa-miR-424	CLIP-seq
MIRT1490790	hsa-miR-4256	CLIP-seq
MIRT1490791	hsa-miR-4428	CLIP-seq
MIRT1490792	hsa-miR-4477b	CLIP-seq
MIRT1490793	hsa-miR-450b-3p	CLIP-seq
MIRT1490794	hsa-miR-4528	CLIP-seq
MIRT1490795	hsa-miR-466	CLIP-seq
MIRT1490796	hsa-miR-4666-3p	CLIP-seq
MIRT1490797	hsa-miR-4672	CLIP-seq
MIRT1490798	hsa-miR-4690-5p	CLIP-seq
MIRT1490799	hsa-miR-4699-3p	CLIP-seq
MIRT1490800	hsa-miR-4713-3p	CLIP-seq
MIRT1490801	hsa-miR-4717-3p	CLIP-seq
MIRT1490802	hsa-miR-4731-3p	CLIP-seq
MIRT1490803	hsa-miR-4778-5p	CLIP-seq
MIRT1490804	hsa-miR-4801	CLIP-seq
MIRT1490805	hsa-miR-4802-3p	CLIP-seq
MIRT1490806	hsa-miR-497	CLIP-seq
MIRT1490807	hsa-miR-513a-3p	CLIP-seq
MIRT1490808	hsa-miR-544	CLIP-seq
MIRT1490809	hsa-miR-638	CLIP-seq
MIRT1490810	hsa-miR-655	CLIP-seq
MIRT1490811	hsa-miR-7	CLIP-seq
MIRT1490812	hsa-miR-769-3p	CLIP-seq
MIRT2147927	hsa-miR-1343	CLIP-seq
MIRT2147928	hsa-miR-3074-5p	CLIP-seq
MIRT2147929	hsa-miR-3117-5p	CLIP-seq
MIRT2147930	hsa-miR-3124-3p	CLIP-seq
MIRT2147931	hsa-miR-3690	CLIP-seq
MIRT2147932	hsa-miR-3936	CLIP-seq
MIRT2147933	hsa-miR-4254	CLIP-seq
MIRT2147934	hsa-miR-4638-3p	CLIP-seq
MIRT2147935	hsa-miR-4757-5p	CLIP-seq
MIRT2147936	hsa-miR-517a	CLIP-seq
MIRT2147937	hsa-miR-517c	CLIP-seq
MIRT2396950	hsa-miR-4499	CLIP-seq
MIRT2463426	hsa-miR-4709-3p	CLIP-seq
MIRT2463426	hsa-miR-4709-3p	CLIP-seq
MIRT2661999	hsa-miR-1253	CLIP-seq
MIRT1490768	hsa-miR-203	CLIP-seq
MIRT1490769	hsa-miR-217	CLIP-seq
MIRT1490771	hsa-miR-3163	CLIP-seq
MIRT1490783	hsa-miR-338-5p	CLIP-seq
MIRT2662000	hsa-miR-3591-3p	CLIP-seq
MIRT1490785	hsa-miR-3688-3p	CLIP-seq
MIRT1490786	hsa-miR-369-3p	CLIP-seq
MIRT1490787	hsa-miR-374c	CLIP-seq
MIRT2662001	hsa-miR-425	CLIP-seq
MIRT1490790	hsa-miR-4256	CLIP-seq
MIRT1490793	hsa-miR-450b-3p	CLIP-seq
MIRT2662002	hsa-miR-4539	CLIP-seq
MIRT2662003	hsa-miR-4646-5p	CLIP-seq
MIRT2662004	hsa-miR-4654	CLIP-seq
MIRT1490796	hsa-miR-4666-3p	CLIP-seq
MIRT1490800	hsa-miR-4713-3p	CLIP-seq
MIRT2662005	hsa-miR-4769-5p	CLIP-seq
MIRT1490805	hsa-miR-4802-3p	CLIP-seq
MIRT2662006	hsa-miR-494	CLIP-seq
MIRT2662007	hsa-miR-548a-5p	CLIP-seq
MIRT2662008	hsa-miR-548ab	CLIP-seq
MIRT2662009	hsa-miR-548ak	CLIP-seq
MIRT2662010	hsa-miR-548b-5p	CLIP-seq
MIRT2662011	hsa-miR-548c-5p	CLIP-seq
MIRT2662012	hsa-miR-548d-5p	CLIP-seq
MIRT2662013	hsa-miR-548h	CLIP-seq
MIRT2662014	hsa-miR-548i	CLIP-seq
MIRT2662015	hsa-miR-548j	CLIP-seq
MIRT2662016	hsa-miR-548n	CLIP-seq
MIRT2662017	hsa-miR-548p	CLIP-seq
MIRT2662018	hsa-miR-548w	CLIP-seq
MIRT2662019	hsa-miR-548y	CLIP-seq
MIRT2662020	hsa-miR-559	CLIP-seq
MIRT1490809	hsa-miR-638	CLIP-seq
MIRT1490810	hsa-miR-655	CLIP-seq
MIRT2662021	hsa-miR-656	CLIP-seq
MIRT1490812	hsa-miR-769-3p	CLIP-seq
MIRT2662000	hsa-miR-3591-3p	CLIP-seq
MIRT1490786	hsa-miR-369-3p	CLIP-seq
MIRT1490787	hsa-miR-374c	CLIP-seq
MIRT2147932	hsa-miR-3936	CLIP-seq
MIRT2662001	hsa-miR-425	CLIP-seq
MIRT2662004	hsa-miR-4654	CLIP-seq
MIRT2147935	hsa-miR-4757-5p	CLIP-seq
MIRT2662005	hsa-miR-4769-5p	CLIP-seq
MIRT1490805	hsa-miR-4802-3p	CLIP-seq
MIRT2662006	hsa-miR-494	CLIP-seq
MIRT2147936	hsa-miR-517a	CLIP-seq
MIRT2147937	hsa-miR-517c	CLIP-seq
MIRT1490810	hsa-miR-655	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0006914	Process	Autophagy	IEA
GO:0007026	Process	Negative regulation of microtubule depolymerization	IEA
GO:0007420	Process	Brain development	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0021801	Process	Cerebral cortex radial glia-guided migration	IEA
GO:0021960	Process	Anterior commissure morphogenesis	IEA
GO:0021987	Process	Cerebral cortex development	IEA
GO:0022038	Process	Corpus callosum development	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030426	Component	Growth cone	IEA
GO:0031175	Process	Neuron projection development	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0061351	Process	Neural precursor cell proliferation	IEA
GO:0061744	Process	Motor behavior	IEA
GO:0097150	Process	Neuronal stem cell population maintenance	IEA
GO:0120168	Process	Detection of hot stimulus involved in thermoception	IEA

Other IDs

• MIM: 615734
• HGNC: 29141
• e!Ensembl: ENSG00000085433

Protein

• UniProt ID: O94967
• Protein name: WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	649 → 687	WD domain, G-beta repeat	Repeat
  PF00400	WD40	745 → 782	WD domain, G-beta repeat	Repeat
  PF00400	WD40	832 → 870	WD domain, G-beta repeat	Repeat
  PF00400	WD40	787 → 828	WD domain, G-beta repeat	Repeat
  PF17814	LisH_TPL	12 → 40		Domain

• Sequence:

  MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ
  WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHLEFTMQEAVQC
  LHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVAEFIPADR
  KLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLCGNGCDDL
  DLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSPYPSSPMR
  RPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGVQNLSRSL
  MLENTECHSIYEESPERDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPAKQEKNELR
  DSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLTEQFLNRSI
  QKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLTHDASNIHT
  STPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCI
  NILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHH
  KGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGP
  ESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRF
  WDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHP
  HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQD
  LSFLSSSADRTVTLWTYNG

• Sequence length: 919

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	39609633	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (6)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cardiovascular Abnormalities	Cardiovascular abnormalities	Pubtator	35474353	Associate	★☆☆☆☆ Found in Text Mining only
Heart Defects Congenital	Congenital heart defect	Pubtator	35474353	Associate	★☆☆☆☆ Found in Text Mining only
Heterotaxy Syndrome	Heterotaxy syndrome	Pubtator	35474353	Associate	★☆☆☆☆ Found in Text Mining only
Lissencephaly	Lissencephaly	BEFREE	29078390		★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	BEFREE	29078390		★☆☆☆☆ Found in Text Mining only
Situs Inversus	Situs inversus	Pubtator	35474353	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for WDR47.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to WDR47.