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Gene Gene information from NCBI Gene database.
Entrez ID 115825
Gene name WD repeat and FYVE domain containing 2
Gene symbol WDFY2
Synonyms (NCBI Gene)
PROFWDF2ZFYVE22
Chromosome 13
Chromosome location 13q14.3
Summary This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
440 Show/Hide all (440)
miRTarBase ID miRNA Experiments Reference
MIRT437528 hsa-miR-19b-3p Immunoprecipitaion 22382630
MIRT651610 hsa-miR-24-3p HITS-CLIP 23824327
MIRT651609 hsa-miR-4255 HITS-CLIP 23824327
MIRT651608 hsa-miR-10b-3p HITS-CLIP 23824327
MIRT651607 hsa-miR-545-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13 Show/Hide all (13)
GO ID Ontology Definition Evidence Reference
GO:0001934 Process Positive regulation of protein phosphorylation IDA 17313651
GO:0005515 Function Protein binding IPI 16792529, 17313651, 25036637, 32296183, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005768 Component Endosome IEA
GO:0005769 Component Early endosome IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610418 20482 ENSG00000139668
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96P53
Protein name WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22)
Protein function Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 189 → 227 WD domain, G-beta repeat Repeat
PF00400 WD40 356 → 394 WD domain, G-beta repeat Repeat
PF00400 WD40 233 → 270 WD domain, G-beta repeat Repeat
PF01363 FYVE 279 → 353 FYVE zinc finger Domain
Sequence
MAAEIQPKPLTRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYW
PSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMI
LFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVT
ILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQG
HNDRVQALSYAQHTRQLISCGGDGGIVVWN
MDVERQETPEWLDSDSCQKCDQPFFWNFKQ
MWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITD
EERAPTA
TFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWD
MTPVVS
Sequence length 400
Interactions View interactions