WASHC2C (WASH complex subunit 2C)

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Gene Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 253725
• Gene name: WASH complex subunit 2C
• Gene symbol: WASHC2C
• Synonyms (NCBI Gene): FAM21A, FAM21C, VPEF
• Chromosome: 10
• Chromosome location: 10q11.22

Gene ontology (GO) Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19922874, 22070227, 23331060, 24643499, 24980502, 25355947, 35271311
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IDA	20498093
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	20498093
GO:0005730	Component	Nucleolus	IDA
GO:0005768	Component	Endosome	IDA	20923837
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IBA
GO:0005769	Component	Early endosome	IDA	19922874
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0010314	Function	Phosphatidylinositol-5-phosphate binding	IDA	20498093
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016197	Process	Endosomal transport	NAS	19922875
GO:0031901	Component	Early endosome membrane	IEA
GO:0031901	Component	Early endosome membrane	NAS	19922874
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IDA	20498093
GO:0032456	Process	Endocytic recycling	IMP	25278552
GO:0034315	Process	Regulation of Arp2/3 complex-mediated actin nucleation	NAS	19922875
GO:0036010	Process	Protein localization to endosome	IBA
GO:0036010	Process	Protein localization to endosome	IMP	28892079
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IMP	19922874
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	IDA	20498093
GO:0070273	Function	Phosphatidylinositol-4-phosphate binding	IDA	20498093
GO:0071203	Component	WASH complex	IBA
GO:0071203	Component	WASH complex	IDA	19922875
GO:0071203	Component	WASH complex	NAS	19922875
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IDA	20498093
GO:1900024	Process	Regulation of substrate adhesion-dependent cell spreading	IDA	22070227
GO:1901981	Function	Phosphatidylinositol phosphate binding	IBA
GO:1905394	Function	Retromer complex binding	IBA
GO:1905394	Function	Retromer complex binding	IDA	23331060
GO:1905394	Function	Retromer complex binding	IMP	27385586
GO:2000813	Process	Negative regulation of barbed-end actin filament capping	IDA	20498093

Other IDs

• MIM: 613631
• HGNC: 23414
• e!Ensembl: ENSG00000172661

Protein

• UniProt ID: Q9Y4E1
• Protein name: WASH complex subunit 2C (Vaccinia virus penetration factor) (VPEF)
• Protein function: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15255	CAP-ZIP_m	923 → 1060	WASH complex subunit CAP-Z interacting, central region	Family

• Sequence:

  MMNRTTPDQELVPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHE
  IKKQVDGLIRETKATDCRLHNVFNDFLMLSNTQFIENRVYDEEVEEPVLKAEAEKTEQEK
  TREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYI
  DRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDN
  EQNQHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGD
  AMGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGL
  FSGGKGLFDDEDEESDLFTEASQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFG
  AASVPSLKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTRKVQSTA
  DIFGDEEGDLFKEKAVASPEATVSQTDENKARAEKKVTLSYSKNLKPSSETKTQKGLFSD
  EEDSEDLFSSQSASNLKGASLLPGKLPTSVSLFDDEDEEDNLFGGTAAKKQTLSLQAQRE
  EKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVK
  KTSLFEEDKEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVS
  EAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHS
  DLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNIIQAPQKEVGKGCDPDAHPKSTGVF
  QDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEK
  KRVVKKDHSVNSFKNQKHPESIQGSKEKGIWKPETPQANLAINPAALLPTAASQISEVKP
  VLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGKRRPQ
  TRAARRLAAQESSEAEDMSVPRGPIAQWADGAISPNGHRPQLRAASGEDSTEEALAAAAA
  PWEGGPVPGVDTSPFAKSLGHSRGEADLFDSGDIFSTGTGSQSVERTKPKAKIAENPANP
  PVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFPLLEDEDDLFTDQKVKKNETKS
  SSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLESNLFDDNIDIFADLTVKPKEKS
  KKKVEAKSIFDDDMDDIFSTGIQAKTTKPKSRSAQAAPEPRFEHKVSNIFDDPLNAFGGQ
  

• Sequence length: 1320

Pathways

KEGG Pathway:

Endocytosis

Related Genes

No strongly related genes found yet for WASHC2C.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to WASHC2C.