Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	387680
Gene name	WASH complex subunit 2A
Gene symbol	WASHC2A
Synonyms (NCBI Gene)	FAM21AFAM21BbA56A21.1bA98I6.1
Chromosome	10
Chromosome location	10q11.23

23 Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25355947, 29084197
GO:0005730	Component	Nucleolus	IDA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IBA
GO:0005769	Component	Early endosome	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016197	Process	Endosomal transport	NAS	19922875
GO:0031901	Component	Early endosome membrane	IEA
GO:0031901	Component	Early endosome membrane	NAS	19922874
GO:0034315	Process	Regulation of Arp2/3 complex-mediated actin nucleation	NAS	19922875
GO:0036010	Process	Protein localization to endosome	IBA
GO:0036010	Process	Protein localization to endosome	IMP	28892079
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0042147	Process	Retrograde transport, endosome to Golgi	ISS
GO:0071203	Component	WASH complex	IBA
GO:0071203	Component	WASH complex	ISS
GO:0071203	Component	WASH complex	NAS	19922875
GO:1901981	Function	Phosphatidylinositol phosphate binding	IBA
GO:1905394	Function	Retromer complex binding	IBA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q641Q2

Protein name

WASH complex subunit 2A

Protein function

Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is

PDB

8RKS , 8TTA , 8TTC , 8TTD , 8TTT , 8TTU , 8TTV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15255	CAP-ZIP_m	944 → 1081	WASH complex subunit CAP-Z interacting, central region	Family

Sequence

MMNRTTPDQELAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHE
IKKQVDGLIRETKATDCRLHNVFNDFLMLSNTQFIENRVYDEEVEEPVLKAEAEKTEQEK
TREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYI
DRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDN
EQNRHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGD
AVGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGL
FSGGKGLFDDEDEESDLFTEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFG
AASVPSMKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTGKVQSTA
DIFGDEEGDLFKEKAVASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSD
EEDSEDLFSSQSASKLKGASLLPGKLPTLVSLFDDEDEEDNLFGGTAAKKQTLCLQAQRE
EKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVK
KTSLFEEDEEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVS
EAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHS
DLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNIIQAPQKEVGKGRDPDAHPKSTGVF
QDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEK
KRVVKKDHSVDSFKNQKHPESIQGSKEKGIWKPETPQDSSGLAPFKTKEPSTRIGKIQAN
LAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQ
ADTLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADGAISPNGHR
PQLRAASGEDSTEEALAAAAAPWEGGPVPGVDRSPFAKSLGHSRGEADLFDSGDIFSTGT
GSQSVERTKPKAKIAENPANPPVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFP
LLEDEDDLFTDQKVKKNETKSNSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLES
NLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDMDDIFSSGIQAKTTKPKSRSAQAAPE
PRFEHKVSNIFDDPLNAFGGQ

Sequence length

1341

Interactions

View interactions

KEGG Pathway
Endocytosis

Related Genes Genes most often co-reported with WASHC2A across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for WASHC2A.

Diseases Linked via Similar Genes Diseases curated for genes most similar to WASHC2A (see Related Genes above), that are NOT already directly curated for WASHC2A itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to WASHC2A.

WASHC2A (WASH complex subunit 2A)

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