VWA5A (von Willebrand factor A domain containing 5A)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 4013
• Gene name: Von Willebrand factor A domain containing 5A
• Gene symbol: VWA5A
• Synonyms (NCBI Gene): BCSC-1, BCSC1, LOH11CR2A
• Chromosome: 11
• Chromosome location: 11q24.2

miRNA Show/Hide all (95)

miRTarBase ID	miRNA	Experiments	Reference
MIRT572423	hsa-miR-6761-3p	PAR-CLIP	20371350
MIRT572421	hsa-miR-5193	PAR-CLIP	20371350
MIRT572420	hsa-miR-660-3p	PAR-CLIP	20371350
MIRT572419	hsa-miR-1291	PAR-CLIP	20371350
MIRT572418	hsa-miR-6775-3p	PAR-CLIP	20371350
MIRT572417	hsa-miR-6851-3p	PAR-CLIP	20371350
MIRT572416	hsa-miR-328-3p	PAR-CLIP	20371350
MIRT572423	hsa-miR-6761-3p	PAR-CLIP	20371350
MIRT572421	hsa-miR-5193	PAR-CLIP	20371350
MIRT572420	hsa-miR-660-3p	PAR-CLIP	20371350
MIRT572419	hsa-miR-1291	PAR-CLIP	20371350
MIRT572418	hsa-miR-6775-3p	PAR-CLIP	20371350
MIRT572417	hsa-miR-6851-3p	PAR-CLIP	20371350
MIRT572416	hsa-miR-328-3p	PAR-CLIP	20371350
MIRT1488300	hsa-miR-1264	CLIP-seq
MIRT1488301	hsa-miR-2682	CLIP-seq
MIRT1488302	hsa-miR-3190	CLIP-seq
MIRT1488303	hsa-miR-34a	CLIP-seq
MIRT1488304	hsa-miR-34c-5p	CLIP-seq
MIRT1488305	hsa-miR-3613-5p	CLIP-seq
MIRT1488306	hsa-miR-3617	CLIP-seq
MIRT1488307	hsa-miR-3691-3p	CLIP-seq
MIRT1488308	hsa-miR-4269	CLIP-seq
MIRT1488309	hsa-miR-449a	CLIP-seq
MIRT1488310	hsa-miR-449b	CLIP-seq
MIRT1488311	hsa-miR-449c	CLIP-seq
MIRT1488312	hsa-miR-4514	CLIP-seq
MIRT1488313	hsa-miR-4692	CLIP-seq
MIRT1488314	hsa-miR-4731-3p	CLIP-seq
MIRT1488315	hsa-miR-4742-5p	CLIP-seq
MIRT1488316	hsa-miR-4801	CLIP-seq
MIRT1488317	hsa-miR-641	CLIP-seq
MIRT1488318	hsa-miR-7	CLIP-seq
MIRT1488319	hsa-miR-298	CLIP-seq
MIRT1488302	hsa-miR-3190	CLIP-seq
MIRT1488305	hsa-miR-3613-5p	CLIP-seq
MIRT1488306	hsa-miR-3617	CLIP-seq
MIRT1488320	hsa-miR-3647-3p	CLIP-seq
MIRT1488321	hsa-miR-4684-5p	CLIP-seq
MIRT1488322	hsa-miR-4735-5p	CLIP-seq
MIRT1488323	hsa-miR-4760-3p	CLIP-seq
MIRT1488317	hsa-miR-641	CLIP-seq
MIRT1488318	hsa-miR-7	CLIP-seq
MIRT1488324	hsa-miR-4270	CLIP-seq
MIRT1488325	hsa-miR-4441	CLIP-seq
MIRT1488326	hsa-miR-5095	CLIP-seq
MIRT1488327	hsa-miR-513a-3p	CLIP-seq
MIRT1488328	hsa-miR-539	CLIP-seq
MIRT2147033	hsa-miR-3120-3p	CLIP-seq
MIRT1488314	hsa-miR-4731-3p	CLIP-seq
MIRT1488316	hsa-miR-4801	CLIP-seq
MIRT2661032	hsa-miR-3147	CLIP-seq
MIRT2661033	hsa-miR-3616-3p	CLIP-seq
MIRT2661034	hsa-miR-3945	CLIP-seq
MIRT2661035	hsa-miR-4303	CLIP-seq
MIRT2661036	hsa-miR-4425	CLIP-seq
MIRT2661037	hsa-miR-4649-3p	CLIP-seq
MIRT2661038	hsa-miR-4721	CLIP-seq
MIRT2661039	hsa-miR-4761-3p	CLIP-seq
MIRT2661040	hsa-miR-4762-3p	CLIP-seq
MIRT2661041	hsa-miR-4781-3p	CLIP-seq
MIRT2661042	hsa-miR-668	CLIP-seq
MIRT2695109	hsa-miR-2052	CLIP-seq
MIRT2661032	hsa-miR-3147	CLIP-seq
MIRT2695110	hsa-miR-3153	CLIP-seq
MIRT2695111	hsa-miR-3545-3p	CLIP-seq
MIRT2695112	hsa-miR-3609	CLIP-seq
MIRT2661033	hsa-miR-3616-3p	CLIP-seq
MIRT2695113	hsa-miR-3622a-3p	CLIP-seq
MIRT2695114	hsa-miR-3622b-3p	CLIP-seq
MIRT2661034	hsa-miR-3945	CLIP-seq
MIRT2695115	hsa-miR-4254	CLIP-seq
MIRT2695116	hsa-miR-4292	CLIP-seq
MIRT2661035	hsa-miR-4303	CLIP-seq
MIRT2695117	hsa-miR-4307	CLIP-seq
MIRT2695118	hsa-miR-4308	CLIP-seq
MIRT2661036	hsa-miR-4425	CLIP-seq
MIRT2695119	hsa-miR-4446-5p	CLIP-seq
MIRT2695120	hsa-miR-4468	CLIP-seq
MIRT2661037	hsa-miR-4649-3p	CLIP-seq
MIRT2695121	hsa-miR-4668-5p	CLIP-seq
MIRT2695122	hsa-miR-4680-5p	CLIP-seq
MIRT2661038	hsa-miR-4721	CLIP-seq
MIRT2695123	hsa-miR-4755-5p	CLIP-seq
MIRT2661039	hsa-miR-4761-3p	CLIP-seq
MIRT2661040	hsa-miR-4762-3p	CLIP-seq
MIRT2661041	hsa-miR-4781-3p	CLIP-seq
MIRT2695124	hsa-miR-490-3p	CLIP-seq
MIRT2695125	hsa-miR-520g	CLIP-seq
MIRT2695126	hsa-miR-520h	CLIP-seq
MIRT2695127	hsa-miR-548ah	CLIP-seq
MIRT2695128	hsa-miR-619	CLIP-seq
MIRT2661042	hsa-miR-668	CLIP-seq
MIRT2695129	hsa-miR-670	CLIP-seq
MIRT2695130	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA

Other IDs

• MIM: 602929
• HGNC: 6658
• e!Ensembl: ENSG00000110002

Protein

• UniProt ID: O00534
• Protein name: von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein)
• Protein function: May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08487	VIT	17 → 129	Vault protein inter-alpha-trypsin domain	Family
  PF13768	VWA_3	280 → 443	von Willebrand factor type A domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested. {ECO:0000269|PubMed:14504409}.
• Sequence:

  MVHFCGLLTLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSA
  VYSFEALVDGKKIVAELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPG
  SKAAVTLKYVQELPLEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTPIVPVEDLPYTL
  SMVATIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQVSLAAGHKFDRDVELLIYYNEVHTP
  SVVLEMGMPNMKPGHLMGDPSAMVSFYPNIPEDQPSNTCGEFIFLMDRSGSMQSPMSSQD
  TSQLRIQAAKETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLM
  QADLGGTEILAPLQNIYRGPSIPGHPLQLFVFTDGEVTDTFSVIKEVRINRQKHRCFSFG
  IGEGTSTSLIKGIARASGGTSEFITGKDRMQSKALRTLKRSLQPVVEDVSLSWHLPPGLS
  AKMLSPEQTVIFRGQRLISYAQLTGRMPAAETTGEVCLKYTLQGKTFEDKVTFPLQPKPD
  VNLTIHRLAAKSLLQTKDMGLRETPASDKKDALNLSLESGVISSFTAFIAINKELNKPVQ
  GPLAHRDVPRPILLGASAPLKIKCQSGFRKALHSDRPPSASQPRGELMCYKAKTFQMDDY
  SLCGLISHKDQHSPGFGENHLVQLIYHQNANGSWDLNEDLAKILGMSLEEIMAAQPAELV
  DSSGWATILAVIWLHSNGKDLKCEWELLERKAVAWMRAHAGSTMPSVVKAAITFLKSSVD
  PAIFAF

• Sequence length: 786

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (13)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	21803008, 29512758, 29552138		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21803008	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	38291227	Inhibit	★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	21154811		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	21803008, 38291227	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29512758, 29552138		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19656157, 29512758, 29552138		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	22594792		★☆☆☆☆ Found in Text Mining only
Metastatic melanoma	Metastatic Melanoma	BEFREE	22594792		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	19656157		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19656157, 21803008, 22594792, 29512758, 29552138, 9417908		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	34716291	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for VWA5A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to VWA5A.