VTI1B (vesicle transport through interaction with t-SNAREs 1B)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10490
• Gene name: Vesicle transport through interaction with t-SNAREs 1B
• Gene symbol: VTI1B
• Synonyms (NCBI Gene): VTI1, VTI1-LIKE, VTI1L, VTI2, v-SNARE, vti1-rp1
• Chromosome: 14
• Chromosome location: 14q24.1

miRNA Show/Hide all (161)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001397	hsa-miR-16-5p	pSILAC	18668040
MIRT028226	hsa-miR-33a-5p	Sequencing	20371350
MIRT001397	hsa-miR-16-5p	Microarray	21199864
MIRT001397	hsa-miR-16-5p	Proteomics	18668040
MIRT495497	hsa-miR-596	PAR-CLIP	22291592
MIRT495496	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT495495	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT495494	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT495493	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT495492	hsa-miR-940	PAR-CLIP	22291592
MIRT495491	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT495490	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT495489	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT495488	hsa-miR-4722-3p	PAR-CLIP	22291592
MIRT495487	hsa-miR-6727-3p	PAR-CLIP	22291592
MIRT495486	hsa-miR-4763-5p	PAR-CLIP	22291592
MIRT495485	hsa-miR-4423-3p	PAR-CLIP	22291592
MIRT495497	hsa-miR-596	PAR-CLIP	22291592
MIRT495496	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT495495	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT495494	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT495493	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT495492	hsa-miR-940	PAR-CLIP	22291592
MIRT495491	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT495490	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT495489	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT495488	hsa-miR-4722-3p	PAR-CLIP	22291592
MIRT495487	hsa-miR-6727-3p	PAR-CLIP	22291592
MIRT495486	hsa-miR-4763-5p	PAR-CLIP	22291592
MIRT495485	hsa-miR-4423-3p	PAR-CLIP	22291592
MIRT1488179	hsa-miR-1238	CLIP-seq
MIRT1488180	hsa-miR-1284	CLIP-seq
MIRT1488181	hsa-miR-140-5p	CLIP-seq
MIRT1488182	hsa-miR-1470	CLIP-seq
MIRT1488183	hsa-miR-148a	CLIP-seq
MIRT1488184	hsa-miR-148b	CLIP-seq
MIRT1488185	hsa-miR-152	CLIP-seq
MIRT1488186	hsa-miR-15a	CLIP-seq
MIRT1488187	hsa-miR-15b	CLIP-seq
MIRT1488188	hsa-miR-16	CLIP-seq
MIRT1488189	hsa-miR-186	CLIP-seq
MIRT1488190	hsa-miR-188-3p	CLIP-seq
MIRT1488191	hsa-miR-195	CLIP-seq
MIRT1488192	hsa-miR-205	CLIP-seq
MIRT1488193	hsa-miR-23a	CLIP-seq
MIRT1488194	hsa-miR-23b	CLIP-seq
MIRT1488195	hsa-miR-23c	CLIP-seq
MIRT1488196	hsa-miR-3124-3p	CLIP-seq
MIRT1488197	hsa-miR-3133	CLIP-seq
MIRT1488198	hsa-miR-3200-3p	CLIP-seq
MIRT1488199	hsa-miR-324-5p	CLIP-seq
MIRT1488200	hsa-miR-3545-3p	CLIP-seq
MIRT1488201	hsa-miR-362-5p	CLIP-seq
MIRT1488202	hsa-miR-3663-5p	CLIP-seq
MIRT1488203	hsa-miR-3942-5p	CLIP-seq
MIRT1488204	hsa-miR-3974	CLIP-seq
MIRT1488205	hsa-miR-424	CLIP-seq
MIRT1488206	hsa-miR-4310	CLIP-seq
MIRT1488207	hsa-miR-4326	CLIP-seq
MIRT1488208	hsa-miR-4457	CLIP-seq
MIRT1488209	hsa-miR-4469	CLIP-seq
MIRT1488210	hsa-miR-4667-3p	CLIP-seq
MIRT1488211	hsa-miR-4690-3p	CLIP-seq
MIRT1488212	hsa-miR-4691-5p	CLIP-seq
MIRT1488213	hsa-miR-4703-5p	CLIP-seq
MIRT1488214	hsa-miR-4724-3p	CLIP-seq
MIRT1488215	hsa-miR-4729	CLIP-seq
MIRT1488216	hsa-miR-4794	CLIP-seq
MIRT1488217	hsa-miR-497	CLIP-seq
MIRT1488218	hsa-miR-500b	CLIP-seq
MIRT1488219	hsa-miR-513b	CLIP-seq
MIRT1488220	hsa-miR-532-3p	CLIP-seq
MIRT1488221	hsa-miR-556-3p	CLIP-seq
MIRT1488222	hsa-miR-586	CLIP-seq
MIRT1488223	hsa-miR-624	CLIP-seq
MIRT1488179	hsa-miR-1238	CLIP-seq
MIRT1488180	hsa-miR-1284	CLIP-seq
MIRT1488181	hsa-miR-140-5p	CLIP-seq
MIRT1488182	hsa-miR-1470	CLIP-seq
MIRT1488183	hsa-miR-148a	CLIP-seq
MIRT1488184	hsa-miR-148b	CLIP-seq
MIRT1488185	hsa-miR-152	CLIP-seq
MIRT1488186	hsa-miR-15a	CLIP-seq
MIRT1488187	hsa-miR-15b	CLIP-seq
MIRT1488188	hsa-miR-16	CLIP-seq
MIRT1488190	hsa-miR-188-3p	CLIP-seq
MIRT1488191	hsa-miR-195	CLIP-seq
MIRT1488192	hsa-miR-205	CLIP-seq
MIRT1488193	hsa-miR-23a	CLIP-seq
MIRT1488194	hsa-miR-23b	CLIP-seq
MIRT1488195	hsa-miR-23c	CLIP-seq
MIRT1488196	hsa-miR-3124-3p	CLIP-seq
MIRT1488199	hsa-miR-324-5p	CLIP-seq
MIRT1488200	hsa-miR-3545-3p	CLIP-seq
MIRT1488201	hsa-miR-362-5p	CLIP-seq
MIRT1488202	hsa-miR-3663-5p	CLIP-seq
MIRT1488203	hsa-miR-3942-5p	CLIP-seq
MIRT1488205	hsa-miR-424	CLIP-seq
MIRT1488207	hsa-miR-4326	CLIP-seq
MIRT1488209	hsa-miR-4469	CLIP-seq
MIRT1488210	hsa-miR-4667-3p	CLIP-seq
MIRT1488211	hsa-miR-4690-3p	CLIP-seq
MIRT1488212	hsa-miR-4691-5p	CLIP-seq
MIRT1488213	hsa-miR-4703-5p	CLIP-seq
MIRT1488216	hsa-miR-4794	CLIP-seq
MIRT1488217	hsa-miR-497	CLIP-seq
MIRT1488218	hsa-miR-500b	CLIP-seq
MIRT1488220	hsa-miR-532-3p	CLIP-seq
MIRT1488179	hsa-miR-1238	CLIP-seq
MIRT1488180	hsa-miR-1284	CLIP-seq
MIRT1488182	hsa-miR-1470	CLIP-seq
MIRT1488183	hsa-miR-148a	CLIP-seq
MIRT1488184	hsa-miR-148b	CLIP-seq
MIRT1488185	hsa-miR-152	CLIP-seq
MIRT1488189	hsa-miR-186	CLIP-seq
MIRT1488190	hsa-miR-188-3p	CLIP-seq
MIRT2367521	hsa-miR-3074-3p	CLIP-seq
MIRT1488196	hsa-miR-3124-3p	CLIP-seq
MIRT1488197	hsa-miR-3133	CLIP-seq
MIRT1488198	hsa-miR-3200-3p	CLIP-seq
MIRT1488199	hsa-miR-324-5p	CLIP-seq
MIRT1488200	hsa-miR-3545-3p	CLIP-seq
MIRT1488201	hsa-miR-362-5p	CLIP-seq
MIRT1488202	hsa-miR-3663-5p	CLIP-seq
MIRT1488203	hsa-miR-3942-5p	CLIP-seq
MIRT1488204	hsa-miR-3974	CLIP-seq
MIRT1488206	hsa-miR-4310	CLIP-seq
MIRT1488208	hsa-miR-4457	CLIP-seq
MIRT1488209	hsa-miR-4469	CLIP-seq
MIRT1488210	hsa-miR-4667-3p	CLIP-seq
MIRT1488212	hsa-miR-4691-5p	CLIP-seq
MIRT1488213	hsa-miR-4703-5p	CLIP-seq
MIRT1488214	hsa-miR-4724-3p	CLIP-seq
MIRT1488215	hsa-miR-4729	CLIP-seq
MIRT1488216	hsa-miR-4794	CLIP-seq
MIRT2367522	hsa-miR-487a	CLIP-seq
MIRT1488218	hsa-miR-500b	CLIP-seq
MIRT1488219	hsa-miR-513b	CLIP-seq
MIRT1488220	hsa-miR-532-3p	CLIP-seq
MIRT1488221	hsa-miR-556-3p	CLIP-seq
MIRT1488222	hsa-miR-586	CLIP-seq
MIRT1488223	hsa-miR-624	CLIP-seq
MIRT1488186	hsa-miR-15a	CLIP-seq
MIRT1488187	hsa-miR-15b	CLIP-seq
MIRT1488188	hsa-miR-16	CLIP-seq
MIRT1488191	hsa-miR-195	CLIP-seq
MIRT1488203	hsa-miR-3942-5p	CLIP-seq
MIRT1488205	hsa-miR-424	CLIP-seq
MIRT1488211	hsa-miR-4690-3p	CLIP-seq
MIRT1488213	hsa-miR-4703-5p	CLIP-seq
MIRT1488217	hsa-miR-497	CLIP-seq
MIRT1488222	hsa-miR-586	CLIP-seq
MIRT1488186	hsa-miR-15a	CLIP-seq
MIRT1488187	hsa-miR-15b	CLIP-seq
MIRT1488188	hsa-miR-16	CLIP-seq
MIRT1488191	hsa-miR-195	CLIP-seq
MIRT1488203	hsa-miR-3942-5p	CLIP-seq
MIRT1488205	hsa-miR-424	CLIP-seq
MIRT1488211	hsa-miR-4690-3p	CLIP-seq
MIRT1488213	hsa-miR-4703-5p	CLIP-seq
MIRT1488217	hsa-miR-497	CLIP-seq

Gene ontology (GO) Show/Hide all (50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0000149	Function	SNARE binding	IDA	24550300
GO:0005484	Function	SNAP receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	16189514, 18033301, 21516116, 25416956, 28514442, 31515488, 32296183, 33961781, 35156780, 35271311, 36012204
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	18033301, 23217709
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	19224922
GO:0005829	Component	Cytosol	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006891	Process	Intra-Golgi vesicle-mediated transport	IBA
GO:0006896	Process	Golgi to vacuole transport	IBA
GO:0006904	Process	Vesicle docking involved in exocytosis	TAS	9446565
GO:0008021	Component	Synaptic vesicle	IEA
GO:0008021	Component	Synaptic vesicle	ISS
GO:0012505	Component	Endomembrane system	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016192	Process	Vesicle-mediated transport	TAS	9446565
GO:0016236	Process	Macroautophagy	IBA
GO:0019869	Function	Chloride channel inhibitor activity	IDA	18570918
GO:0031093	Component	Platelet alpha granule lumen	TAS
GO:0031201	Component	SNARE complex	IBA
GO:0031201	Component	SNARE complex	IEA
GO:0031901	Component	Early endosome membrane	IDA	18033301
GO:0031901	Component	Early endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	IBA
GO:0031902	Component	Late endosome membrane	IDA	18033301, 23217709
GO:0031902	Component	Late endosome membrane	IEA
GO:0031982	Component	Vesicle	IDA	18570918
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043025	Component	Neuronal cell body	ISS
GO:0048280	Process	Vesicle fusion with Golgi apparatus	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	18570918
GO:0055037	Component	Recycling endosome	IDA	18570918
GO:0055038	Component	Recycling endosome membrane	IDA	18033301
GO:0055038	Component	Recycling endosome membrane	IEA
GO:0061025	Process	Membrane fusion	TAS	9446565
GO:0097352	Process	Autophagosome maturation	IMP	23217709
GO:0098954	Component	Presynaptic endosome membrane	IEA
GO:1903076	Process	Regulation of protein localization to plasma membrane	IBA
GO:1903076	Process	Regulation of protein localization to plasma membrane	IDA	18570918

Other IDs

• MIM: 603207
• HGNC: 17793
• e!Ensembl: ENSG00000100568

Protein

• UniProt ID: Q9UEU0
• Protein name: Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1)
• Protein function: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.
• PDB: 2V8S
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05008	V-SNARE	18 → 97	Vesicle transport v-SNARE protein N-terminus	Family
  PF12352	V-SNARE_C	137 → 202		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in all tissues examined.
• Sequence:

  MASSAASSEHFEKLHEIFRGLHEDLQGVPERLLGTAGTEEKKKLIRDFDEKQQEANETLA
  EMEEELRYAPLSFRNPMMSKLRNYRKDLAKLHREVRSTPLTATPGGRGDMKYGIYAVENE
  HMNRLQSQRAMLLQGTESLNRATQSIERSHRIATETDQIGSEIIEELGEQRDQLERTKSR
  LVNTSENLSKSRKILRSMSRKVTTNKLLLSIIILLELAILGGLVYYKFFRSH

• Sequence length: 232

Pathways

KEGG Pathway:

SNARE interactions in vesicular transport

Reactome Pathway:

Platelet degranulation

Related Genes

No strongly related genes found yet for VTI1B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to VTI1B.