VSIR (V-set immunoregulatory receptor)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 64115
• Gene name: V-set immunoregulatory receptor
• Gene symbol: VSIR
• Synonyms (NCBI Gene): B7-H5, B7H5, C10orf54, DD1alpha, Dies1, GI24, PD-1H, PP2135, SISP1, VISTA
• Chromosome: 10
• Chromosome location: 10q22.1

miRNA Show/Hide all (33)

miRTarBase ID	miRNA	Experiments	Reference
MIRT487394	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT487393	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT487392	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT487391	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT487390	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT487389	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT487388	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT487387	hsa-miR-759	PAR-CLIP	23592263
MIRT487386	hsa-miR-922	PAR-CLIP	23592263
MIRT487385	hsa-miR-4533	PAR-CLIP	23592263
MIRT487384	hsa-miR-3202	PAR-CLIP	23592263
MIRT487383	hsa-miR-6081	PAR-CLIP	23592263
MIRT487382	hsa-miR-765	PAR-CLIP	23592263
MIRT487381	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT487380	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT487379	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT487378	hsa-miR-4525	PAR-CLIP	23592263
MIRT487377	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT487375	hsa-miR-6835-5p	PAR-CLIP	23592263
MIRT487376	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT487374	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT487373	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT487372	hsa-miR-4651	PAR-CLIP	23592263
MIRT487371	hsa-miR-608	PAR-CLIP	23592263
MIRT487370	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT487369	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT487368	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT487367	hsa-miR-4447	PAR-CLIP	23592263
MIRT487366	hsa-miR-4472	PAR-CLIP	23592263
MIRT487365	hsa-miR-1275	PAR-CLIP	23592263
MIRT487364	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT487363	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT487362	hsa-miR-6803-5p	PAR-CLIP	23592263

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20666777
GO:0005886	Component	Plasma membrane	IEA
GO:0010628	Process	Positive regulation of gene expression	IMP	20666777
GO:0010950	Process	Positive regulation of endopeptidase activity	IDA	20666777
GO:0016020	Component	Membrane	IEA
GO:0019899	Function	Enzyme binding	IPI	20666777
GO:0030335	Process	Positive regulation of cell migration	IDA	20666777
GO:0031638	Process	Zymogen activation	IDA	20666777
GO:0032689	Process	Negative regulation of type II interferon production	IDA	24691993
GO:0032693	Process	Negative regulation of interleukin-10 production	IDA	24691993
GO:0032700	Process	Negative regulation of interleukin-17 production	IDA	24691993
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IDA	24691993
GO:0042802	Function	Identical protein binding	IPI	26228159
GO:0045591	Process	Positive regulation of regulatory T cell differentiation	IMP	24691993
GO:0046636	Process	Negative regulation of alpha-beta T cell activation	IBA
GO:0050776	Process	Regulation of immune response	IEA
GO:0061133	Function	Endopeptidase activator activity	IDA	20666777
GO:0120158	Process	Positive regulation of collagen catabolic process	IDA	20666777
GO:2000562	Process	Negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP	24691993
GO:2000565	Process	Negative regulation of CD8-positive, alpha-beta T cell proliferation	IMP	24691993

Other IDs

• MIM: 615608
• HGNC: 30085
• e!Ensembl: ENSG00000107738

Protein

• UniProt ID: Q9H7M9
• Protein name: V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor)
• Protein function: Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {E
• PDB: 6MVL , 6OIL , 6U6V , 8TBQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	38 → 169	Immunoglobulin V-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at hig
• Sequence:

  MGVPTALEAGSWRWGSLLFALFLAASLGPVAAFKVATPYSLYVCPEGQNVTLTCRLLGPV
  DKGHDVTFYKTWYRSSRGEVQTCSERRPIRNLTFQDLHLHHGGHQAANTSHDLAQRHGLE
  SASDHHGNFSITMRNLTLLDSGLYCCLVVEIRHHHSEHRVHGAMELQVQTGKDAPSNCVV
  YPSSSQDSENITAAALATGACIVGILCLPLILLLVYKQRQAASNRRAQELVRMDSNIQGI
  ENPGFEASPPAQGIPEAKVRHPLSYVAQRQPSESGRHLLSEPSTPLSPPGPGDVFFPSLD
  PVPDSPNFEVI

• Sequence length: 311

Pathways

KEGG Pathway:

Cell adhesion molecules

Related Genes

No strongly related genes found yet for VSIR.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to VSIR.