VILL (villin like)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 50853
• Gene name: Villin like
• Gene symbol: VILL
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3p22.2
• Summary: The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. [provided by RefSeq, Jul 2008]

miRNA Show/Hide all (13)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018239	hsa-miR-335-5p	Microarray	18185580
MIRT2145907	hsa-miR-2355-5p	CLIP-seq
MIRT2145908	hsa-miR-338-3p	CLIP-seq
MIRT2145909	hsa-miR-3918	CLIP-seq
MIRT2145910	hsa-miR-4310	CLIP-seq
MIRT2145911	hsa-miR-4512	CLIP-seq
MIRT2145907	hsa-miR-2355-5p	CLIP-seq
MIRT2366327	hsa-miR-3190	CLIP-seq
MIRT2145908	hsa-miR-338-3p	CLIP-seq
MIRT2145909	hsa-miR-3918	CLIP-seq
MIRT2145910	hsa-miR-4310	CLIP-seq
MIRT2145911	hsa-miR-4512	CLIP-seq
MIRT2366328	hsa-miR-671-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	9179494
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0008154	Process	Actin polymerization or depolymerization	IBA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0015629	Component	Actin cytoskeleton	TAS	9179494
GO:0051014	Process	Actin filament severing	IBA
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IEA
GO:0051016	Process	Barbed-end actin filament capping	IBA
GO:0051693	Process	Actin filament capping	IEA

Other IDs

• MIM: 619666
• HGNC: 30906
• e!Ensembl: ENSG00000136059

Protein

• UniProt ID: O15195
• Protein name: Villin-like protein
• Protein function: Possible tumor suppressor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00626	Gelsolin	266 → 341	Gelsolin repeat	Domain
  PF00626	Gelsolin	624 → 699	Gelsolin repeat	Domain
  PF00626	Gelsolin	400 → 482	Gelsolin repeat	Domain
  PF00626	Gelsolin	144 → 220	Gelsolin repeat	Domain
  PF00626	Gelsolin	21 → 106	Gelsolin repeat	Domain
  PF00626	Gelsolin	519 → 588	Gelsolin repeat	Domain
  PF02209	VHP	821 → 856	Villin headpiece domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed in 16 tissues examined.
• Sequence:

  MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDL
  HYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGL
  ASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKT
  SISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPS
  KDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRM
  SSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGR
  DKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCY
  LVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPH
  FLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFL
  LVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSN
  KRLPEEVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAAS
  EWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVV
  DGSPAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSR
  TSSSVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYS
  MATWRQRQEKKQLGFF

• Sequence length: 856

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Melanoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VILL-related disorder	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	23478628	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	23478628	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for VILL.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to VILL.