Gene Gene information from NCBI Gene database.
Entrez ID 7423
Gene name Vascular endothelial growth factor B
Gene symbol VEGFB
Synonyms (NCBI Gene)
VEGFLVRF
Chromosome 11
Chromosome location 11q13.1
Summary This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a lig
miRNA miRNA information provided by mirtarbase database.
106
miRTarBase ID miRNA Experiments Reference
MIRT651751 hsa-miR-361-5p HITS-CLIP 23824327
MIRT651750 hsa-miR-6768-5p HITS-CLIP 23824327
MIRT651749 hsa-miR-6808-5p HITS-CLIP 23824327
MIRT651748 hsa-miR-6893-5p HITS-CLIP 23824327
MIRT651747 hsa-miR-940 HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
7
Transcription factor Regulation Reference
FOXM1 Unknown 21860419
FOXO3 Unknown 21860419
HDGF Activation 14662017
HIF1A Unknown 21731766
STAT3 Unknown 16899623;21731766
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
41
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IBA
GO:0001938 Process Positive regulation of endothelial cell proliferation IDA 8637916, 11122379
GO:0002040 Process Sprouting angiogenesis IBA
GO:0005172 Function Vascular endothelial growth factor receptor binding IBA
GO:0005515 Function Protein binding IPI 11122379, 19483306, 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601398 12681 ENSG00000173511
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P49765
Protein name Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF)
Protein function Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
PDB 2C7W , 2VWE , 2XAC , 6TKK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00341 PDGF 47 124 PDGF/VEGF domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Sequence
MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVEL
MGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHS
QCEC
RPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAP
STTSALTPGPAAAAADAAASSVAKGGA
Sequence length 207
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Familial cancer of breast Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenoma Adenoma BEFREE 12754739, 28110235
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 31332262 Stimulate
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 36680854, 36905877, 37354922 Associate
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 11303624
★☆☆☆☆
Found in Text Mining only
Behcet Syndrome Behcet Syndrome BEFREE 30420902
★☆☆☆☆
Found in Text Mining only
Behcet Syndrome Behcet disease Pubtator 30420902 Associate
★☆☆☆☆
Found in Text Mining only
Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia BEFREE 15107801
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 19424629
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma CTD_human_DG 23146280
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 10551327 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations