USPL1 (ubiquitin specific peptidase like 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10208
• Gene name: Ubiquitin specific peptidase like 1
• Gene symbol: USPL1
• Synonyms (NCBI Gene): C13orf22, D13S106E, bA121O19.1
• Chromosome: 13
• Chromosome location: 13q12.3

miRNA Show/Hide all (28)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044741	hsa-miR-320a	CLASH	23622248
MIRT043177	hsa-miR-324-5p	CLASH	23622248
MIRT1480848	hsa-miR-1206	CLIP-seq
MIRT1480849	hsa-miR-3200-3p	CLIP-seq
MIRT1480850	hsa-miR-33a	CLIP-seq
MIRT1480851	hsa-miR-33b	CLIP-seq
MIRT1480852	hsa-miR-375	CLIP-seq
MIRT1480853	hsa-miR-3977	CLIP-seq
MIRT1480854	hsa-miR-4666-5p	CLIP-seq
MIRT2365040	hsa-miR-1825	CLIP-seq
MIRT2365041	hsa-miR-199a-5p	CLIP-seq
MIRT2365042	hsa-miR-199b-5p	CLIP-seq
MIRT2365043	hsa-miR-3941	CLIP-seq
MIRT2365044	hsa-miR-466	CLIP-seq
MIRT2365045	hsa-miR-4672	CLIP-seq
MIRT2365046	hsa-miR-4731-3p	CLIP-seq
MIRT2365047	hsa-miR-4801	CLIP-seq
MIRT2365048	hsa-miR-568	CLIP-seq
MIRT2365040	hsa-miR-1825	CLIP-seq
MIRT2365041	hsa-miR-199a-5p	CLIP-seq
MIRT2365042	hsa-miR-199b-5p	CLIP-seq
MIRT2365043	hsa-miR-3941	CLIP-seq
MIRT2365044	hsa-miR-466	CLIP-seq
MIRT2365045	hsa-miR-4672	CLIP-seq
MIRT2365046	hsa-miR-4731-3p	CLIP-seq
MIRT2365047	hsa-miR-4801	CLIP-seq
MIRT2434505	hsa-miR-556-3p	CLIP-seq
MIRT2365048	hsa-miR-568	CLIP-seq

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21988832, 22878415, 24413172, 25416956, 35914814
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008283	Process	Cell population proliferation	IMP	22878415
GO:0009301	Process	SnRNA transcription	IMP	24413172
GO:0015030	Component	Cajal body	IBA
GO:0015030	Component	Cajal body	IDA	22878415, 24413172
GO:0015030	Component	Cajal body	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016926	Process	Protein desumoylation	IBA
GO:0016926	Process	Protein desumoylation	IDA	22878415
GO:0016929	Function	DeSUMOylase activity	IDA	22878415
GO:0030576	Process	Cajal body organization	IBA
GO:0030576	Process	Cajal body organization	IEA
GO:0030576	Process	Cajal body organization	IMP	22878415
GO:0032183	Function	SUMO binding	IBA
GO:0032183	Function	SUMO binding	IDA	22878415
GO:0032183	Function	SUMO binding	IEA
GO:0043130	Function	Ubiquitin binding	IDA	22878415

Other IDs

• MIM: 617470
• HGNC: 20294
• e!Ensembl: ENSG00000132952

Protein

• UniProt ID: Q5W0Q7
• Protein name: SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1)
• Protein function: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (Pu
• PDB: 7P99 , 7ZJU , 7ZJV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15499	Peptidase_C98	226 → 498	Ubiquitin-specific peptidase-like, SUMO isopeptidase	Family
  PF15509	DUF4650	572 → 1090	Domain of unknown function (DUF4650)	Family

• Sequence:

  MMDSPKIGNGLPVIGPGTDIGISSLHMVGYLGKNFDSAKVPSDEYCPACREKGKLKALKT
  YRISFQESIFLCEDLQCIYPLGSKSLNNLISPDLEECHTPHKPQKRKSLESSYKDSLLLA
  NSKKTRNYIAIDGGKVLNSKHNGEVYDETSSNLPDSSGQQNPIRTADSLERNEILEADTV
  DMATTKDPATVDVSGTGRPSPQNEGCTSKLEMPLESKCTSFPQALCVQWKNAYALCWLDC
  ILSALVHSEELKNTVTGLCSKEESIFWRLLTKYNQANTLLYTSQLSGVKDGDCKKLTSEI
  FAEIETCLNEVRDEIFISLQPQLRCTLGDMESPVFAFPLLLKLETHIEKLFLYSFSWDFE
  CSQCGHQYQNRHMKSLVTFTNVIPEWHPLNAAHFGPCNNCNSKSQIRKMVLEKVSPIFML
  HFVEGLPQNDLQHYAFHFEGCLYQITSVIQYRANNHFITWILDADGSWLECDDLKGPCSE
  RHKKFEVPASEIHIVIWERKISQVTDKEAACLPLKKTNDQHALSNEKPVSLTSCSVGDAA
  SAETASVTHPKDISVAPRTLSQDTAVTHGDHLLSGPKGLVDNILPLTLEETIQKTASVSQ
  LNSEAFLLENKPVAENTGILKTNTLLSQESLMASSVSAPCNEKLIQDQFVDISFPSQVVN
  TNMQSVQLNTEDTVNTKSVNNTDATGLIQGVKSVEIEKDAQLKQFLTPKTEQLKPERVTS
  QVSNLKKKETTADSQTTTSKSLQNQSLKENQKKPFVGSWVKGLISRGASFMPLCVSAHNR
  NTITDLQPSVKGVNNFGGFKTKGINQKASHVSKKARKSASKPPPISKPPAGPPSSNGTAA
  HPHAHAASEVLEKSGSTSCGAQLNHSSYGNGISSANHEDLVEGQIHKLRLKLRKKLKAEK
  KKLAALMSSPQSRTVRSENLEQVPQDGSPNDCESIEDLLNELPYPIDIASESACTTVPGV
  SLYSSQTHEEILAELLSPTPVSTELSENGEGDFRYLGMGDSHIPPPVPSEFNDVSQNTHL
  RQDHNYCSPTKKNPCEVQPDSLTNNACVRTLNLESPMKTDIFDEFFSSSALNALANDTLD
  LPHFDEYLFENY

• Sequence length: 1092

Related Genes

No strongly related genes found yet for USPL1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to USPL1.