USP51 (ubiquitin specific peptidase 51)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 158880
• Gene name: Ubiquitin specific peptidase 51
• Gene symbol: USP51
• Synonyms (NCBI Gene): -
• Chromosome: X
• Chromosome location: Xp11.21

miRNA Show/Hide all (115)

miRTarBase ID	miRNA	Experiments	Reference
MIRT503520	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503519	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT503518	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT503517	hsa-miR-4798-3p	HITS-CLIP	21572407
MIRT503516	hsa-miR-3680-5p	HITS-CLIP	21572407
MIRT503515	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503514	hsa-miR-342-3p	HITS-CLIP	21572407
MIRT503513	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503512	hsa-miR-377-3p	HITS-CLIP	21572407
MIRT503520	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT503517	hsa-miR-4798-3p	HITS-CLIP	23313552
MIRT503516	hsa-miR-3680-5p	HITS-CLIP	23313552
MIRT503515	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT503514	hsa-miR-342-3p	HITS-CLIP	23313552
MIRT503513	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT503512	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT503520	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503519	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT503518	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT503517	hsa-miR-4798-3p	PAR-CLIP	21572407
MIRT503516	hsa-miR-3680-5p	PAR-CLIP	21572407
MIRT503515	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503514	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT503513	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503512	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT526349	hsa-miR-4668-3p	PAR-CLIP	22012620
MIRT526348	hsa-miR-338-5p	PAR-CLIP	22012620
MIRT526347	hsa-miR-3163	PAR-CLIP	22012620
MIRT526346	hsa-miR-95-5p	PAR-CLIP	22012620
MIRT526345	hsa-miR-4705	PAR-CLIP	22012620
MIRT526344	hsa-miR-4719	PAR-CLIP	22012620
MIRT526343	hsa-miR-187-5p	PAR-CLIP	22012620
MIRT503520	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503519	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT503518	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT503517	hsa-miR-4798-3p	PAR-CLIP	23446348
MIRT503516	hsa-miR-3680-5p	PAR-CLIP	23446348
MIRT503515	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503514	hsa-miR-342-3p	PAR-CLIP	23446348
MIRT503513	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503512	hsa-miR-377-3p	PAR-CLIP	23446348
MIRT503520	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503519	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT503518	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT503517	hsa-miR-4798-3p	HITS-CLIP	21572407
MIRT503516	hsa-miR-3680-5p	HITS-CLIP	21572407
MIRT503515	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503514	hsa-miR-342-3p	HITS-CLIP	21572407
MIRT503513	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503512	hsa-miR-377-3p	HITS-CLIP	21572407
MIRT503520	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT503517	hsa-miR-4798-3p	HITS-CLIP	23313552
MIRT503516	hsa-miR-3680-5p	HITS-CLIP	23313552
MIRT503515	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT503514	hsa-miR-342-3p	HITS-CLIP	23313552
MIRT503513	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT503512	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT503520	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503519	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT503518	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT503517	hsa-miR-4798-3p	PAR-CLIP	21572407
MIRT503516	hsa-miR-3680-5p	PAR-CLIP	21572407
MIRT503515	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503514	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT503513	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503512	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT526349	hsa-miR-4668-3p	PAR-CLIP	22012620
MIRT526348	hsa-miR-338-5p	PAR-CLIP	22012620
MIRT526347	hsa-miR-3163	PAR-CLIP	22012620
MIRT526346	hsa-miR-95-5p	PAR-CLIP	22012620
MIRT526345	hsa-miR-4705	PAR-CLIP	22012620
MIRT526344	hsa-miR-4719	PAR-CLIP	22012620
MIRT526343	hsa-miR-187-5p	PAR-CLIP	22012620
MIRT503520	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503519	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT503518	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT503517	hsa-miR-4798-3p	PAR-CLIP	23446348
MIRT503516	hsa-miR-3680-5p	PAR-CLIP	23446348
MIRT503515	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503514	hsa-miR-342-3p	PAR-CLIP	23446348
MIRT503513	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503512	hsa-miR-377-3p	PAR-CLIP	23446348
MIRT1480245	hsa-miR-1193	CLIP-seq
MIRT1480246	hsa-miR-1225-3p	CLIP-seq
MIRT1480247	hsa-miR-27a	CLIP-seq
MIRT1480248	hsa-miR-27b	CLIP-seq
MIRT1480249	hsa-miR-335	CLIP-seq
MIRT1480250	hsa-miR-3942-3p	CLIP-seq
MIRT1480251	hsa-miR-4662a-3p	CLIP-seq
MIRT1480252	hsa-miR-4679	CLIP-seq
MIRT1480253	hsa-miR-4684-5p	CLIP-seq
MIRT1480254	hsa-miR-4790-3p	CLIP-seq
MIRT1480255	hsa-miR-513a-5p	CLIP-seq
MIRT1480256	hsa-miR-513b	CLIP-seq
MIRT1480257	hsa-miR-942	CLIP-seq
MIRT2144503	hsa-miR-4729	CLIP-seq
MIRT2364790	hsa-miR-1179	CLIP-seq
MIRT2364791	hsa-miR-202	CLIP-seq
MIRT2364792	hsa-miR-3973	CLIP-seq
MIRT2364793	hsa-miR-4271	CLIP-seq
MIRT2364794	hsa-miR-4279	CLIP-seq
MIRT2364795	hsa-miR-4283	CLIP-seq
MIRT2364796	hsa-miR-431	CLIP-seq
MIRT2364797	hsa-miR-4443	CLIP-seq
MIRT2364798	hsa-miR-4489	CLIP-seq
MIRT2364799	hsa-miR-4528	CLIP-seq
MIRT2364800	hsa-miR-4635	CLIP-seq
MIRT2364801	hsa-miR-4716-3p	CLIP-seq
MIRT2364802	hsa-miR-4725-3p	CLIP-seq
MIRT1480254	hsa-miR-4790-3p	CLIP-seq
MIRT2364803	hsa-miR-511	CLIP-seq
MIRT2364804	hsa-miR-548k	CLIP-seq
MIRT2364805	hsa-miR-548m	CLIP-seq
MIRT2364806	hsa-miR-579	CLIP-seq
MIRT2364807	hsa-miR-625	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IDA	27083998
GO:0004843	Function	Cysteine-type deubiquitinase activity	IDA	14715245, 34188037
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0005634	Component	Nucleus	IC	34188037
GO:0005694	Component	Chromosome	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0006974	Process	DNA damage response	IDA	19500350, 34188037
GO:0006974	Process	DNA damage response	IDA	27083998, 34188037
GO:0006974	Process	DNA damage response	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010564	Process	Regulation of cell cycle process	IMP	27083998
GO:0010569	Process	Regulation of double-strand break repair via homologous recombination	IMP	27083998
GO:0016579	Process	Protein deubiquitination	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0042393	Function	Histone binding	IDA	27083998
GO:0046872	Function	Metal ion binding	IEA
GO:0140861	Process	DNA repair-dependent chromatin remodeling	IMP	27083998
GO:0140950	Function	Histone H2A deubiquitinase activity	IDA	27083998
GO:0140950	Function	Histone H2A deubiquitinase activity	IEA
GO:2001032	Process	Regulation of double-strand break repair via nonhomologous end joining	IMP	27083998

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q70EK9
• Protein name: Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.4.19.12) (Deubiquitinating enzyme 51) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51)
• Protein function: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998, PubMed:33022275). USP51 is recruited to chromatin after DNA damage and reg
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00443	UCH	363 → 703	Ubiquitin carboxyl-terminal hydrolase	Family
  PF02148	zf-UBP	236 → 297	Zn-finger in ubiquitin-hydrolases and other protein	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in prostate, brain, lung, aorta and kidney. {ECO:0000269|PubMed:14715245}.
• Sequence:

  MAQVRETSLPSGSGVRWISGGGGGASPEEAVEKAGKMEEAAAGATKASSRREAEEMKLEP
  LQEREPAPEENLTWSSSGGDEKVLPSIPLRCHSSSSPVCPRRKPRPRPQPRARSRSQPGL
  SAPPPPPARPPPPPPPPPPPAPRPRAWRGSRRRSRPGSRPQTRRSCSGDLDGSGDPGGLG
  DWLLEVEFGQGPTGCSHVESFKVGKNWQKNLRLIYQRFVWSGTPETRKRKAKSCICHVCS
  THMNRLHSCLSCVFFGCFTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYVYDKDIEQI
  AKETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCETKEQEPKLVKPKKKRRKKSVYTV
  GLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYS
  GSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRHSKDDSGGQEANNPNCC
  NCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRD
  DHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFE
  HVGKQRRKINTFISFPLELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGT
  LESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLYSEGYLLFYHKQGLEKD

• Sequence length: 711

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Short stature	Pathogenic	rs1569197778	RCV000736242	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ANDROGENETIC ALOPECIA	—	GWAS catalog	30573740	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (10)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	29119051		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37816999	Associate	★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	31217854		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	37816999	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	32468048	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29119051		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	31217854		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27132940		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	26261572	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36603607	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for USP51.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to USP51.