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Gene Gene information from NCBI Gene database.
Entrez ID 57695
Gene name Ubiquitin specific peptidase 37
Gene symbol USP37
Synonyms (NCBI Gene)
-
Chromosome 2
Chromosome location 2q35
miRNA miRNA information provided by mirtarbase database.
772 Show/Hide all (772)
miRTarBase ID miRNA Experiments Reference
MIRT031252 hsa-miR-19b-3p Sequencing 20371350
MIRT051589 hsa-let-7e-5p CLASH 23622248
MIRT047922 hsa-miR-30c-5p CLASH 23622248
MIRT697766 hsa-miR-548av-3p HITS-CLIP 23313552
MIRT697765 hsa-miR-191-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28 Show/Hide all (28)
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IBA
GO:0000082 Process G1/S transition of mitotic cell cycle IDA 21596315
GO:0004197 Function Cysteine-type endopeptidase activity IDA 21596315
GO:0004843 Function Cysteine-type deubiquitinase activity IBA
GO:0004843 Function Cysteine-type deubiquitinase activity IDA 14715245, 21596315
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620226 20063 ENSG00000135913
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86T82
Protein name Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37)
Protein function Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed:26299517, PubMed:27296872, PubMed:31911859, PubMed:34509474). Antagonizes the anaphase-promoting complex (APC
PDB 3U12
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00443 UCH 341 → 948 Ubiquitin carboxyl-terminal hydrolase Family
PF02809 UIM 828 → 844 Ubiquitin interaction motif Motif
PF02809 UIM 806 → 822 Ubiquitin interaction motif Motif
PF16674 UCH_N 1 → 105 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in brain and prostate. {ECO:0000269|PubMed:14715245}.
Sequence
Sequence length 979
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Ub-specific processing proteases