UPRT (uracil phosphoribosyltransferase homolog)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 139596
• Gene name: Uracil phosphoribosyltransferase homolog
• Gene symbol: UPRT
• Synonyms (NCBI Gene): FUR1, UPP
• Chromosome: X
• Chromosome location: Xq13.3
• Summary: This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salv

miRNA Show/Hide all (85)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1476443	hsa-miR-1251	CLIP-seq
MIRT1476444	hsa-miR-193a-3p	CLIP-seq
MIRT1476445	hsa-miR-193b	CLIP-seq
MIRT1476446	hsa-miR-3187-3p	CLIP-seq
MIRT1476447	hsa-miR-3646	CLIP-seq
MIRT1476448	hsa-miR-3662	CLIP-seq
MIRT1476449	hsa-miR-3688-5p	CLIP-seq
MIRT1476450	hsa-miR-411	CLIP-seq
MIRT1476451	hsa-miR-4307	CLIP-seq
MIRT1476452	hsa-miR-4501	CLIP-seq
MIRT1476453	hsa-miR-4529-5p	CLIP-seq
MIRT1476454	hsa-miR-4699-3p	CLIP-seq
MIRT1476455	hsa-miR-4732-5p	CLIP-seq
MIRT1476456	hsa-miR-494	CLIP-seq
MIRT1476457	hsa-miR-513a-3p	CLIP-seq
MIRT1476458	hsa-miR-548c-3p	CLIP-seq
MIRT1476459	hsa-miR-889	CLIP-seq
MIRT1476460	hsa-miR-892b	CLIP-seq
MIRT2143538	hsa-miR-30a	CLIP-seq
MIRT2143539	hsa-miR-30b	CLIP-seq
MIRT2143540	hsa-miR-30c	CLIP-seq
MIRT2143541	hsa-miR-30d	CLIP-seq
MIRT2143542	hsa-miR-30e	CLIP-seq
MIRT2143543	hsa-miR-3125	CLIP-seq
MIRT2143544	hsa-miR-3916	CLIP-seq
MIRT2143545	hsa-miR-4287	CLIP-seq
MIRT2143546	hsa-miR-4469	CLIP-seq
MIRT2143547	hsa-miR-4685-3p	CLIP-seq
MIRT2143548	hsa-miR-4709-5p	CLIP-seq
MIRT2143549	hsa-miR-877	CLIP-seq
MIRT2363724	hsa-miR-1	CLIP-seq
MIRT2363725	hsa-miR-1302	CLIP-seq
MIRT2363726	hsa-miR-206	CLIP-seq
MIRT2143543	hsa-miR-3125	CLIP-seq
MIRT2363727	hsa-miR-3133	CLIP-seq
MIRT1476449	hsa-miR-3688-5p	CLIP-seq
MIRT2143544	hsa-miR-3916	CLIP-seq
MIRT2363728	hsa-miR-4298	CLIP-seq
MIRT2363729	hsa-miR-4511	CLIP-seq
MIRT2363730	hsa-miR-4648	CLIP-seq
MIRT2363731	hsa-miR-613	CLIP-seq
MIRT2143549	hsa-miR-877	CLIP-seq
MIRT2363732	hsa-miR-936	CLIP-seq
MIRT1476443	hsa-miR-1251	CLIP-seq
MIRT2657449	hsa-miR-1323	CLIP-seq
MIRT2657450	hsa-miR-155	CLIP-seq
MIRT1476444	hsa-miR-193a-3p	CLIP-seq
MIRT1476445	hsa-miR-193b	CLIP-seq
MIRT2657451	hsa-miR-2054	CLIP-seq
MIRT2657452	hsa-miR-219-5p	CLIP-seq
MIRT2657453	hsa-miR-2467-5p	CLIP-seq
MIRT2657454	hsa-miR-3121-3p	CLIP-seq
MIRT2657455	hsa-miR-3129-3p	CLIP-seq
MIRT1476446	hsa-miR-3187-3p	CLIP-seq
MIRT2657456	hsa-miR-33a	CLIP-seq
MIRT2657457	hsa-miR-33b	CLIP-seq
MIRT1476447	hsa-miR-3646	CLIP-seq
MIRT1476448	hsa-miR-3662	CLIP-seq
MIRT2657458	hsa-miR-4445	CLIP-seq
MIRT2657459	hsa-miR-4474-3p	CLIP-seq
MIRT2657460	hsa-miR-4477a	CLIP-seq
MIRT2657461	hsa-miR-4496	CLIP-seq
MIRT2657462	hsa-miR-4522	CLIP-seq
MIRT1476453	hsa-miR-4529-5p	CLIP-seq
MIRT1476454	hsa-miR-4699-3p	CLIP-seq
MIRT2657463	hsa-miR-4715-3p	CLIP-seq
MIRT2657464	hsa-miR-4735-5p	CLIP-seq
MIRT2657465	hsa-miR-4775	CLIP-seq
MIRT2657466	hsa-miR-4782-3p	CLIP-seq
MIRT2657467	hsa-miR-4795-3p	CLIP-seq
MIRT1476456	hsa-miR-494	CLIP-seq
MIRT2657468	hsa-miR-498	CLIP-seq
MIRT2657469	hsa-miR-508-3p	CLIP-seq
MIRT1476457	hsa-miR-513a-3p	CLIP-seq
MIRT1476458	hsa-miR-548c-3p	CLIP-seq
MIRT2657470	hsa-miR-548o	CLIP-seq
MIRT2657471	hsa-miR-579	CLIP-seq
MIRT2657472	hsa-miR-590-3p	CLIP-seq
MIRT2657473	hsa-miR-656	CLIP-seq
MIRT1476460	hsa-miR-892b	CLIP-seq
MIRT2657453	hsa-miR-2467-5p	CLIP-seq
MIRT2657459	hsa-miR-4474-3p	CLIP-seq
MIRT2657462	hsa-miR-4522	CLIP-seq
MIRT2657468	hsa-miR-498	CLIP-seq
MIRT2657471	hsa-miR-579	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 31515488, 32296183
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006222	Process	UMP biosynthetic process	IEA
GO:0007565	Process	Female pregnancy	IEA
GO:0007595	Process	Lactation	IEA
GO:0032868	Process	Response to insulin	IEA
GO:0050262	Function	Ribosylnicotinamide kinase activity	IBA
GO:0061769	Function	Ribosylnicotinate kinase activity	IBA

Other IDs

• MIM: 300656
• HGNC: 28334
• e!Ensembl: ENSG00000094841

Protein

• UniProt ID: Q96BW1
• Protein name: Uracil phosphoribosyltransferase homolog
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14681	UPRTase	113 → 308		Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle. {ECO:0000269|PubMed:17384901}.
• Sequence:

  MATELQCPDSMPCHNQQVNSASTPSPEQLRPGDLILDHAGGNRASRAKVILLTGYAHSSL
  PAELDSGACGGSSLNSEGNSGSGDSSSYDAPAGNSFLEDCELSRQIGAQLKLLPMNDQIR
  ELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYKECMVTTPTGYKYEGVKFEKGNC
  GVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPI
  LSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTH
  FGQKYFGTD

• Sequence length: 309

Related Genes

No strongly related genes found yet for UPRT.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to UPRT.