UPK1A (uroplakin 1A)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 11045
• Gene name: Uroplakin 1A
• Gene symbol: UPK1A
• Synonyms (NCBI Gene): TSPAN21, UP1A, UPIA, UPKA
• Chromosome: 19
• Chromosome location: 19q13.12
• Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate

miRNA Show/Hide all (68)

miRTarBase ID	miRNA	Experiments	Reference
MIRT732993	hsa-miR-658	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR	32368305
MIRT1476224	hsa-miR-105	CLIP-seq
MIRT1476225	hsa-miR-106a	CLIP-seq
MIRT1476226	hsa-miR-106b	CLIP-seq
MIRT1476227	hsa-miR-17	CLIP-seq
MIRT1476228	hsa-miR-20a	CLIP-seq
MIRT1476229	hsa-miR-20b	CLIP-seq
MIRT1476230	hsa-miR-3144-5p	CLIP-seq
MIRT1476231	hsa-miR-3180-5p	CLIP-seq
MIRT1476232	hsa-miR-3191	CLIP-seq
MIRT1476233	hsa-miR-3609	CLIP-seq
MIRT1476234	hsa-miR-3670	CLIP-seq
MIRT1476235	hsa-miR-4645-3p	CLIP-seq
MIRT1476236	hsa-miR-4652-5p	CLIP-seq
MIRT1476237	hsa-miR-4705	CLIP-seq
MIRT1476238	hsa-miR-4719	CLIP-seq
MIRT1476239	hsa-miR-4796-3p	CLIP-seq
MIRT1476240	hsa-miR-519d	CLIP-seq
MIRT1476241	hsa-miR-520a-5p	CLIP-seq
MIRT1476242	hsa-miR-525-5p	CLIP-seq
MIRT1476243	hsa-miR-542-3p	CLIP-seq
MIRT1476244	hsa-miR-548ah	CLIP-seq
MIRT1476245	hsa-miR-93	CLIP-seq
MIRT1476224	hsa-miR-105	CLIP-seq
MIRT1476225	hsa-miR-106a	CLIP-seq
MIRT1476226	hsa-miR-106b	CLIP-seq
MIRT2363701	hsa-miR-1252	CLIP-seq
MIRT1476227	hsa-miR-17	CLIP-seq
MIRT1476228	hsa-miR-20a	CLIP-seq
MIRT1476229	hsa-miR-20b	CLIP-seq
MIRT2363702	hsa-miR-2115	CLIP-seq
MIRT2363703	hsa-miR-3173-3p	CLIP-seq
MIRT1476231	hsa-miR-3180-5p	CLIP-seq
MIRT1476233	hsa-miR-3609	CLIP-seq
MIRT1476234	hsa-miR-3670	CLIP-seq
MIRT2363704	hsa-miR-3919	CLIP-seq
MIRT2363705	hsa-miR-4291	CLIP-seq
MIRT2363706	hsa-miR-451b	CLIP-seq
MIRT1476235	hsa-miR-4645-3p	CLIP-seq
MIRT2363707	hsa-miR-4659a-5p	CLIP-seq
MIRT2363708	hsa-miR-4659b-5p	CLIP-seq
MIRT1476237	hsa-miR-4705	CLIP-seq
MIRT1476238	hsa-miR-4719	CLIP-seq
MIRT2363709	hsa-miR-4722-3p	CLIP-seq
MIRT2363710	hsa-miR-4756-3p	CLIP-seq
MIRT2363711	hsa-miR-4763-5p	CLIP-seq
MIRT2363712	hsa-miR-4769-3p	CLIP-seq
MIRT1476239	hsa-miR-4796-3p	CLIP-seq
MIRT1476240	hsa-miR-519d	CLIP-seq
MIRT1476241	hsa-miR-520a-5p	CLIP-seq
MIRT1476242	hsa-miR-525-5p	CLIP-seq
MIRT1476243	hsa-miR-542-3p	CLIP-seq
MIRT2363713	hsa-miR-545	CLIP-seq
MIRT1476244	hsa-miR-548ah	CLIP-seq
MIRT2363714	hsa-miR-553	CLIP-seq
MIRT2363715	hsa-miR-765	CLIP-seq
MIRT1476245	hsa-miR-93	CLIP-seq
MIRT1476225	hsa-miR-106a	CLIP-seq
MIRT1476226	hsa-miR-106b	CLIP-seq
MIRT1476227	hsa-miR-17	CLIP-seq
MIRT1476228	hsa-miR-20a	CLIP-seq
MIRT1476229	hsa-miR-20b	CLIP-seq
MIRT1476233	hsa-miR-3609	CLIP-seq
MIRT1476239	hsa-miR-4796-3p	CLIP-seq
MIRT1476240	hsa-miR-519d	CLIP-seq
MIRT1476243	hsa-miR-542-3p	CLIP-seq
MIRT1476244	hsa-miR-548ah	CLIP-seq
MIRT1476245	hsa-miR-93	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28228557
GO:0005783	Component	Endoplasmic reticulum	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	15088894
GO:0009986	Component	Cell surface	IDA	28228557
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016324	Component	Apical plasma membrane	IEA
GO:0030855	Process	Epithelial cell differentiation	IDA	10514386
GO:0032991	Component	Protein-containing complex	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0120001	Component	Apical plasma membrane urothelial plaque	IEA

Other IDs

• MIM: 611557
• HGNC: 12577
• e!Ensembl: ENSG00000105668

Protein

• UniProt ID: O00322
• Protein name: Uroplakin-1a (UP1a) (Tetraspanin-21) (Tspan-21) (Uroplakin Ia) (UPIa) (UPKa)
• Protein function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane perme
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00335	Tetraspanin	16 → 258	Tetraspanin family	Family

• Tissue specificity: TISSUE SPECIFICITY: High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate. Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies.
• Sequence:

  MASAAAAEAEKGSPVVVGLLVVGNIIILLSGLSLFAETIWVTADQYRVYPLMGVSGKDDV
  FAGAWIAIFCGFSFFMVASFGVGAALCRRRSMVLTYLVLMLIVYIFECASCITSYTHRDY
  MVSNPSLITKQMLTFYSADTDQGQELTRLWDRVMIEQECCGTSGPMDWVNFTSAFRAATP
  EVVFPWPPLCCRRTGNFIPLNEEGCRLGHMDYLFTKGCFEHIGHAIDSYTWGISWFGFAI
  LMWTLPVMLIAMYFYTML

• Sequence length: 258

Related Genes

No strongly related genes found yet for UPK1A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to UPK1A.