UNC5A (unc-5 netrin receptor A)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 90249
• Gene name: Unc-5 netrin receptor A
• Gene symbol: UNC5A
• Synonyms (NCBI Gene): UNC5H1
• Chromosome: 5
• Chromosome location: 5q35.2
• Summary: UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]

miRNA Show/Hide all (68)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044601	hsa-miR-320a	CLASH	23622248
MIRT1475436	hsa-miR-1182	CLIP-seq
MIRT1475437	hsa-miR-1207-5p	CLIP-seq
MIRT1475438	hsa-miR-2861	CLIP-seq
MIRT1475439	hsa-miR-3144-5p	CLIP-seq
MIRT1475440	hsa-miR-3181	CLIP-seq
MIRT1475441	hsa-miR-3191	CLIP-seq
MIRT1475442	hsa-miR-3944-3p	CLIP-seq
MIRT1475443	hsa-miR-4292	CLIP-seq
MIRT1475444	hsa-miR-4652-5p	CLIP-seq
MIRT1475445	hsa-miR-4665-3p	CLIP-seq
MIRT1475446	hsa-miR-4667-5p	CLIP-seq
MIRT1475447	hsa-miR-4700-5p	CLIP-seq
MIRT1475448	hsa-miR-4728-5p	CLIP-seq
MIRT1475449	hsa-miR-4750	CLIP-seq
MIRT1475450	hsa-miR-4763-3p	CLIP-seq
MIRT1475451	hsa-miR-615-3p	CLIP-seq
MIRT1922467	hsa-miR-197	CLIP-seq
MIRT1922468	hsa-miR-603	CLIP-seq
MIRT2143250	hsa-miR-138	CLIP-seq
MIRT2143251	hsa-miR-1912	CLIP-seq
MIRT2143252	hsa-miR-214	CLIP-seq
MIRT1475438	hsa-miR-2861	CLIP-seq
MIRT2143253	hsa-miR-3130-5p	CLIP-seq
MIRT2143254	hsa-miR-320b	CLIP-seq
MIRT2143255	hsa-miR-320c	CLIP-seq
MIRT2143256	hsa-miR-320d	CLIP-seq
MIRT2143257	hsa-miR-320e	CLIP-seq
MIRT2143258	hsa-miR-3619-5p	CLIP-seq
MIRT2143259	hsa-miR-4269	CLIP-seq
MIRT2143260	hsa-miR-4280	CLIP-seq
MIRT2143261	hsa-miR-4299	CLIP-seq
MIRT2143262	hsa-miR-4429	CLIP-seq
MIRT2143263	hsa-miR-4482	CLIP-seq
MIRT2143264	hsa-miR-4530	CLIP-seq
MIRT2143265	hsa-miR-4690-5p	CLIP-seq
MIRT2143266	hsa-miR-4693-3p	CLIP-seq
MIRT2143267	hsa-miR-4710	CLIP-seq
MIRT2143268	hsa-miR-4792	CLIP-seq
MIRT2143269	hsa-miR-761	CLIP-seq
MIRT2363547	hsa-miR-1293	CLIP-seq
MIRT2363548	hsa-miR-342-5p	CLIP-seq
MIRT2363549	hsa-miR-3657	CLIP-seq
MIRT1475443	hsa-miR-4292	CLIP-seq
MIRT2363550	hsa-miR-4308	CLIP-seq
MIRT2363551	hsa-miR-4483	CLIP-seq
MIRT2363552	hsa-miR-4651	CLIP-seq
MIRT2363553	hsa-miR-4664-5p	CLIP-seq
MIRT1475448	hsa-miR-4728-5p	CLIP-seq
MIRT2363554	hsa-miR-608	CLIP-seq
MIRT1475437	hsa-miR-1207-5p	CLIP-seq
MIRT2363547	hsa-miR-1293	CLIP-seq
MIRT2396687	hsa-miR-1909	CLIP-seq
MIRT2396688	hsa-miR-3184	CLIP-seq
MIRT2363548	hsa-miR-342-5p	CLIP-seq
MIRT2363549	hsa-miR-3657	CLIP-seq
MIRT2396689	hsa-miR-423-5p	CLIP-seq
MIRT1475443	hsa-miR-4292	CLIP-seq
MIRT2363550	hsa-miR-4308	CLIP-seq
MIRT2363551	hsa-miR-4483	CLIP-seq
MIRT2396690	hsa-miR-4505	CLIP-seq
MIRT2363552	hsa-miR-4651	CLIP-seq
MIRT2363553	hsa-miR-4664-5p	CLIP-seq
MIRT2396691	hsa-miR-4688	CLIP-seq
MIRT1475450	hsa-miR-4763-3p	CLIP-seq
MIRT2396692	hsa-miR-486-3p	CLIP-seq
MIRT1922468	hsa-miR-603	CLIP-seq
MIRT2363554	hsa-miR-608	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005042	Function	Netrin receptor activity	IBA
GO:0005042	Function	Netrin receptor activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0031175	Process	Neuron projection development	ISS
GO:0032589	Component	Neuron projection membrane	ISS
GO:0032809	Component	Neuronal cell body membrane	ISS
GO:0033564	Process	Anterior/posterior axon guidance	IBA
GO:0033564	Process	Anterior/posterior axon guidance	IEA
GO:0038007	Process	Netrin-activated signaling pathway	IEA
GO:0038007	Process	Netrin-activated signaling pathway	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0045121	Component	Membrane raft	IEA

Other IDs

• MIM: 607869
• HGNC: 12567
• e!Ensembl: ENSG00000113763

Protein

• UniProt ID: Q6ZN44
• Protein name: Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A)
• Protein function: Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin
• PDB: 4V2A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00531	Death	760 → 834	Death domain	Domain
  PF00791	ZU5	442 → 539	ZU5 domain	Family
  PF07679	I-set	149 → 239	Immunoglobulin I-set domain	Domain
  PF17217	UPA	589 → 728	UPA domain	Domain

• Sequence:

  MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP
  VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLE
  EYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE
  VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVY
  VDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGP
  EDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADN
  PHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE
  EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYL
  TLHKPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSC
  EGSWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAP
  VACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVP
  SSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSF
  SINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTL
  AQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEA
  EC

• Sequence length: 842

Pathways

KEGG Pathway:

Axon guidance

Reactome Pathway:

Netrin-1 signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
UNC5A-related disorder	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (24)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bladder Neoplasm	Bladder Neoplasm	BEFREE	24737586		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29720215		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29720215, 36531485	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	29720215	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	24737586		★☆☆☆☆ Found in Text Mining only
Cirrhosis	Cirrhosis	BEFREE	28783179		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30811036		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36551254	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	28710382		★☆☆☆☆ Found in Text Mining only
Isaacs syndrome	Isaacs Syndrome	BEFREE	28251919		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28783179, 29277614		★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	28783179		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29720215		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	24737586		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28783179		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	29720215		★☆☆☆☆ Found in Text Mining only
Myasthenia Gravis	Myasthenia gravis	Pubtator	28251919	Associate	★☆☆☆☆ Found in Text Mining only
Myasthenia Gravis	Myasthenia Gravis	BEFREE	28251919		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24737586, 29720215		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	35234293	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	36551254	Associate	★☆☆☆☆ Found in Text Mining only
Thymoma	Thymoma	BEFREE	28251919		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	24737586, 36551254	Associate	★☆☆☆☆ Found in Text Mining only
Venous Thromboembolism	Venous thromboembolism	Pubtator	29117201	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

NTN4 2 shared pathwaysAxon guidance, Netrin-1 signaling Related via 2 shared pathways including Axon guidance, Netrin-1 signaling. NTN1 2 shared pathwaysAxon guidance, Netrin-1 signaling Related via 2 shared pathways including Axon guidance, Netrin-1 signaling. DCC 2 shared pathwaysAxon guidance, Netrin-1 signaling Related via 2 shared pathways including Axon guidance, Netrin-1 signaling.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
NTN4	0	[]	2	["Axon guidance","Netrin-1 signaling"]	0	[]
NTN1	0	[]	2	["Axon guidance","Netrin-1 signaling"]	0	[]
DCC	0	[]	2	["Axon guidance","Netrin-1 signaling"]	0	[]

Diseases Linked via Similar Genes

Gastroesophageal reflux disease Linked via 2 of 3 related genesNTN4, DCC Psychiatric disorders Linked via 2 of 3 related genesNTN4, DCC Central nervous system cancer Linked via 2 of 3 related genesNTN1, DCC Congenital mirror movements Linked via 2 of 3 related genesNTN1, DCC Glioblastoma Linked via 2 of 3 related genesNTN1, DCC

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Gastroesophageal reflux disease	2	["NTN4","DCC"]
Psychiatric disorders	2	["NTN4","DCC"]
Central nervous system cancer	2	["NTN1","DCC"]
Congenital mirror movements	2	["NTN1","DCC"]
Glioblastoma	2	["NTN1","DCC"]