UEVLD (UEV and lactate/malate dehyrogenase domains)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55293
• Gene name: UEV and lactate/malate dehyrogenase domains
• Gene symbol: UEVLD
• Synonyms (NCBI Gene): ATTP, UEV3
• Chromosome: 11
• Chromosome location: 11p15.1

miRNA Show/Hide all (211)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050487	hsa-miR-20a-5p	CLASH	23622248
MIRT721563	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT721562	hsa-miR-1976	HITS-CLIP	19536157
MIRT721561	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT721560	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT651906	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT721559	hsa-miR-378a-5p	HITS-CLIP	19536157
MIRT651904	hsa-miR-7641	HITS-CLIP	19536157
MIRT671551	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT671550	hsa-miR-5693	HITS-CLIP	23824327
MIRT671549	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT671548	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT671547	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT671546	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT671545	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT671543	hsa-miR-4634	HITS-CLIP	23824327
MIRT671544	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT671542	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT671541	hsa-miR-5698	HITS-CLIP	23824327
MIRT651923	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT651922	hsa-miR-371b-3p	HITS-CLIP	23824327
MIRT651921	hsa-miR-371a-3p	HITS-CLIP	23824327
MIRT651920	hsa-miR-33b-3p	HITS-CLIP	23824327
MIRT651919	hsa-miR-515-3p	HITS-CLIP	23824327
MIRT651918	hsa-miR-519e-3p	HITS-CLIP	23824327
MIRT651917	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT651916	hsa-miR-4671-3p	HITS-CLIP	23824327
MIRT651915	hsa-miR-4473	HITS-CLIP	23824327
MIRT651914	hsa-miR-4477a	HITS-CLIP	23824327
MIRT651913	hsa-miR-3591-5p	HITS-CLIP	23824327
MIRT651912	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT651911	hsa-miR-4676-5p	HITS-CLIP	23824327
MIRT651910	hsa-miR-575	HITS-CLIP	23824327
MIRT651909	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT651908	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT651906	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT651907	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT651905	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT651904	hsa-miR-7641	HITS-CLIP	23824327
MIRT651903	hsa-miR-5096	HITS-CLIP	23824327
MIRT553078	hsa-miR-4282	PAR-CLIP	21572407
MIRT553077	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT553076	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT553075	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT553074	hsa-miR-4495	PAR-CLIP	21572407
MIRT553073	hsa-miR-627-3p	PAR-CLIP	21572407
MIRT553072	hsa-miR-4666b	PAR-CLIP	21572407
MIRT721563	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT721562	hsa-miR-1976	HITS-CLIP	19536157
MIRT721561	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT721560	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT651906	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT721559	hsa-miR-378a-5p	HITS-CLIP	19536157
MIRT651904	hsa-miR-7641	HITS-CLIP	19536157
MIRT671551	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT671550	hsa-miR-5693	HITS-CLIP	23824327
MIRT671549	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT671548	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT671547	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT671546	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT671545	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT671543	hsa-miR-4634	HITS-CLIP	23824327
MIRT671544	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT671542	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT671541	hsa-miR-5698	HITS-CLIP	23824327
MIRT651923	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT651922	hsa-miR-371b-3p	HITS-CLIP	23824327
MIRT651921	hsa-miR-371a-3p	HITS-CLIP	23824327
MIRT651920	hsa-miR-33b-3p	HITS-CLIP	23824327
MIRT651919	hsa-miR-515-3p	HITS-CLIP	23824327
MIRT651918	hsa-miR-519e-3p	HITS-CLIP	23824327
MIRT651917	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT651916	hsa-miR-4671-3p	HITS-CLIP	23824327
MIRT651915	hsa-miR-4473	HITS-CLIP	23824327
MIRT651914	hsa-miR-4477a	HITS-CLIP	23824327
MIRT651913	hsa-miR-3591-5p	HITS-CLIP	23824327
MIRT651912	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT651911	hsa-miR-4676-5p	HITS-CLIP	23824327
MIRT651910	hsa-miR-575	HITS-CLIP	23824327
MIRT651909	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT651908	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT651906	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT651907	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT651905	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT651904	hsa-miR-7641	HITS-CLIP	23824327
MIRT651903	hsa-miR-5096	HITS-CLIP	23824327
MIRT553078	hsa-miR-4282	PAR-CLIP	21572407
MIRT553077	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT553076	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT553075	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT553074	hsa-miR-4495	PAR-CLIP	21572407
MIRT553073	hsa-miR-627-3p	PAR-CLIP	21572407
MIRT553072	hsa-miR-4666b	PAR-CLIP	21572407
MIRT1472824	hsa-miR-106a	CLIP-seq
MIRT1472825	hsa-miR-106b	CLIP-seq
MIRT1472826	hsa-miR-17	CLIP-seq
MIRT1472827	hsa-miR-20a	CLIP-seq
MIRT1472828	hsa-miR-20b	CLIP-seq
MIRT1472829	hsa-miR-3609	CLIP-seq
MIRT1472830	hsa-miR-4796-3p	CLIP-seq
MIRT1472831	hsa-miR-519a	CLIP-seq
MIRT1472832	hsa-miR-519d	CLIP-seq
MIRT1472833	hsa-miR-548ah	CLIP-seq
MIRT1472834	hsa-miR-93	CLIP-seq
MIRT1472824	hsa-miR-106a	CLIP-seq
MIRT1472825	hsa-miR-106b	CLIP-seq
MIRT2142349	hsa-miR-1254	CLIP-seq
MIRT2142350	hsa-miR-1290	CLIP-seq
MIRT1472826	hsa-miR-17	CLIP-seq
MIRT1472827	hsa-miR-20a	CLIP-seq
MIRT1472828	hsa-miR-20b	CLIP-seq
MIRT2142351	hsa-miR-2861	CLIP-seq
MIRT2142352	hsa-miR-3116	CLIP-seq
MIRT2142353	hsa-miR-3163	CLIP-seq
MIRT1472829	hsa-miR-3609	CLIP-seq
MIRT2142354	hsa-miR-3941	CLIP-seq
MIRT2142355	hsa-miR-4446-5p	CLIP-seq
MIRT2142356	hsa-miR-466	CLIP-seq
MIRT2142357	hsa-miR-4672	CLIP-seq
MIRT2142358	hsa-miR-4731-3p	CLIP-seq
MIRT2142359	hsa-miR-4775	CLIP-seq
MIRT2142360	hsa-miR-4781-3p	CLIP-seq
MIRT1472830	hsa-miR-4796-3p	CLIP-seq
MIRT2142361	hsa-miR-4801	CLIP-seq
MIRT2142362	hsa-miR-494	CLIP-seq
MIRT1472831	hsa-miR-519a	CLIP-seq
MIRT1472832	hsa-miR-519d	CLIP-seq
MIRT1472833	hsa-miR-548ah	CLIP-seq
MIRT2142363	hsa-miR-548c-3p	CLIP-seq
MIRT2142364	hsa-miR-548n	CLIP-seq
MIRT2142365	hsa-miR-548t	CLIP-seq
MIRT2142366	hsa-miR-587	CLIP-seq
MIRT2142367	hsa-miR-590-3p	CLIP-seq
MIRT2142368	hsa-miR-605	CLIP-seq
MIRT2142369	hsa-miR-642b	CLIP-seq
MIRT2142370	hsa-miR-656	CLIP-seq
MIRT2142371	hsa-miR-802	CLIP-seq
MIRT1472834	hsa-miR-93	CLIP-seq
MIRT1472824	hsa-miR-106a	CLIP-seq
MIRT1472825	hsa-miR-106b	CLIP-seq
MIRT2142349	hsa-miR-1254	CLIP-seq
MIRT2142350	hsa-miR-1290	CLIP-seq
MIRT1472826	hsa-miR-17	CLIP-seq
MIRT1472827	hsa-miR-20a	CLIP-seq
MIRT1472828	hsa-miR-20b	CLIP-seq
MIRT2142351	hsa-miR-2861	CLIP-seq
MIRT2142352	hsa-miR-3116	CLIP-seq
MIRT2142353	hsa-miR-3163	CLIP-seq
MIRT2362903	hsa-miR-340	CLIP-seq
MIRT1472829	hsa-miR-3609	CLIP-seq
MIRT2142354	hsa-miR-3941	CLIP-seq
MIRT2142356	hsa-miR-466	CLIP-seq
MIRT2142357	hsa-miR-4672	CLIP-seq
MIRT2362904	hsa-miR-4690-5p	CLIP-seq
MIRT2142358	hsa-miR-4731-3p	CLIP-seq
MIRT2142360	hsa-miR-4781-3p	CLIP-seq
MIRT1472830	hsa-miR-4796-3p	CLIP-seq
MIRT2142361	hsa-miR-4801	CLIP-seq
MIRT2142362	hsa-miR-494	CLIP-seq
MIRT1472831	hsa-miR-519a	CLIP-seq
MIRT1472832	hsa-miR-519d	CLIP-seq
MIRT2362905	hsa-miR-548a-5p	CLIP-seq
MIRT2362906	hsa-miR-548ab	CLIP-seq
MIRT1472833	hsa-miR-548ah	CLIP-seq
MIRT2362907	hsa-miR-548ak	CLIP-seq
MIRT2362908	hsa-miR-548b-5p	CLIP-seq
MIRT2142363	hsa-miR-548c-3p	CLIP-seq
MIRT2362909	hsa-miR-548c-5p	CLIP-seq
MIRT2362910	hsa-miR-548d-5p	CLIP-seq
MIRT2362911	hsa-miR-548h	CLIP-seq
MIRT2362912	hsa-miR-548i	CLIP-seq
MIRT2362913	hsa-miR-548j	CLIP-seq
MIRT2142364	hsa-miR-548n	CLIP-seq
MIRT2142365	hsa-miR-548t	CLIP-seq
MIRT2362914	hsa-miR-548w	CLIP-seq
MIRT2362915	hsa-miR-548y	CLIP-seq
MIRT2362916	hsa-miR-559	CLIP-seq
MIRT2362917	hsa-miR-562	CLIP-seq
MIRT2142366	hsa-miR-587	CLIP-seq
MIRT2142368	hsa-miR-605	CLIP-seq
MIRT2142369	hsa-miR-642b	CLIP-seq
MIRT1472834	hsa-miR-93	CLIP-seq
MIRT2142349	hsa-miR-1254	CLIP-seq
MIRT2142351	hsa-miR-2861	CLIP-seq
MIRT2142352	hsa-miR-3116	CLIP-seq
MIRT2142368	hsa-miR-605	CLIP-seq
MIRT2142349	hsa-miR-1254	CLIP-seq
MIRT2142351	hsa-miR-2861	CLIP-seq
MIRT2142352	hsa-miR-3116	CLIP-seq
MIRT2142353	hsa-miR-3163	CLIP-seq
MIRT2362903	hsa-miR-340	CLIP-seq
MIRT2142359	hsa-miR-4775	CLIP-seq
MIRT2142360	hsa-miR-4781-3p	CLIP-seq
MIRT2142364	hsa-miR-548n	CLIP-seq
MIRT2142365	hsa-miR-548t	CLIP-seq
MIRT2142367	hsa-miR-590-3p	CLIP-seq
MIRT2142368	hsa-miR-605	CLIP-seq
MIRT2142369	hsa-miR-642b	CLIP-seq
MIRT2142349	hsa-miR-1254	CLIP-seq
MIRT2142351	hsa-miR-2861	CLIP-seq
MIRT2142352	hsa-miR-3116	CLIP-seq
MIRT2142353	hsa-miR-3163	CLIP-seq
MIRT2362903	hsa-miR-340	CLIP-seq
MIRT2142359	hsa-miR-4775	CLIP-seq
MIRT2142360	hsa-miR-4781-3p	CLIP-seq
MIRT2142364	hsa-miR-548n	CLIP-seq
MIRT2142365	hsa-miR-548t	CLIP-seq
MIRT2142367	hsa-miR-590-3p	CLIP-seq
MIRT2142368	hsa-miR-605	CLIP-seq
MIRT2142369	hsa-miR-642b	CLIP-seq
MIRT2142370	hsa-miR-656	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000813	Component	ESCRT I complex	IBA
GO:0003824	Function	Catalytic activity	IEA
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0008333	Process	Endosome to lysosome transport	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0019752	Process	Carboxylic acid metabolic process	IEA
GO:0031982	Component	Vesicle	IEA
GO:0043130	Function	Ubiquitin binding	IBA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

Other IDs

• MIM: 610985
• HGNC: 30866
• e!Ensembl: ENSG00000151116

Protein

• UniProt ID: Q8IX04
• Protein name: Ubiquitin-conjugating enzyme E2 variant 3 (UEV-3) (EV and lactate/malate dehydrogenase domain-containing protein)
• Protein function: Possible negative regulator of polyubiquitination.
• PDB: 2I6T , 3DL2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00056	Ldh_1_N	183 → 316	lactate/malate dehydrogenase, NAD binding domain	Family
  PF02866	Ldh_1_C	319 → 470	lactate/malate dehydrogenase, alpha/beta C-terminal domain	Domain
  PF05743	UEV	21 → 141	UEV domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes. {ECO:0000269|PubMed:12427560}.
• Sequence:

  MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYVFKDSSQKDLLNFTGTIP
  VMYQGNTYNIPIRFWILDSHPFAPPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHP
  KSVIVGLIKEMIAKFQEELPMYSLSSSDEARQVDLLAYIAKITEGVSDTNSKSWANHENK
  TVNKITVVGGGELGIACTLAISAKGIADRLVLLDLSEGTKGATMDLEIFNLPNVEISKDL
  SASAHSKVVIFTVNSLGSSQSYLDVVQSNVDMFRALVPALGHYSQHSVLLVASQPVEIMT
  YVTWKLSTFPANRVIGIGCNLDSQRLQYIITNVLKAQTSGKEVWVIGEQGEDKVLTWSGQ
  EEVVSHTSQVQLSNRAMELLRVKGQRSWSVGLSVADMVDSIVNNKKKVHSVSALAKGYYD
  INSEVFLSLPCILGTNGVSEVIKTTLKEDTVTEKLQSSASSIHSLQQQLKL

• Sequence length: 471

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	28507274	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for UEVLD.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to UEVLD.