UCK1 (uridine-cytidine kinase 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 83549
• Gene name: Uridine-cytidine kinase 1
• Gene symbol: UCK1
• Synonyms (NCBI Gene): URK1
• Chromosome: 9
• Chromosome location: 9q34.13
• Summary: This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzy

miRNA Show/Hide all (198)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024597	hsa-miR-215-5p	Microarray	19074876
MIRT026790	hsa-miR-192-5p	Microarray	19074876
MIRT052275	hsa-let-7b-5p	CLASH	23622248
MIRT043656	hsa-miR-326	CLASH	23622248
MIRT484978	hsa-miR-3125	PAR-CLIP	23592263
MIRT484977	hsa-miR-3916	PAR-CLIP	23592263
MIRT484976	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT484975	hsa-miR-331-3p	PAR-CLIP	23592263
MIRT484974	hsa-miR-4292	PAR-CLIP	23592263
MIRT484973	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT484972	hsa-miR-6852-5p	PAR-CLIP	23592263
MIRT484971	hsa-miR-7155-5p	PAR-CLIP	23592263
MIRT484969	hsa-miR-3195	PAR-CLIP	23592263
MIRT484970	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT484968	hsa-miR-342-5p	PAR-CLIP	23592263
MIRT484967	hsa-miR-4664-5p	PAR-CLIP	23592263
MIRT484966	hsa-miR-4651	PAR-CLIP	23592263
MIRT484965	hsa-miR-608	PAR-CLIP	23592263
MIRT484964	hsa-miR-6747-5p	PAR-CLIP	23592263
MIRT484963	hsa-miR-6737-5p	PAR-CLIP	23592263
MIRT484962	hsa-miR-6812-5p	PAR-CLIP	23592263
MIRT484961	hsa-miR-6819-5p	PAR-CLIP	23592263
MIRT484960	hsa-miR-8060	PAR-CLIP	23592263
MIRT484978	hsa-miR-3125	PAR-CLIP	23592263
MIRT484977	hsa-miR-3916	PAR-CLIP	23592263
MIRT484976	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT484975	hsa-miR-331-3p	PAR-CLIP	23592263
MIRT484974	hsa-miR-4292	PAR-CLIP	23592263
MIRT484973	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT484972	hsa-miR-6852-5p	PAR-CLIP	23592263
MIRT484971	hsa-miR-7155-5p	PAR-CLIP	23592263
MIRT484969	hsa-miR-3195	PAR-CLIP	23592263
MIRT484970	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT484968	hsa-miR-342-5p	PAR-CLIP	23592263
MIRT484967	hsa-miR-4664-5p	PAR-CLIP	23592263
MIRT484966	hsa-miR-4651	PAR-CLIP	23592263
MIRT484965	hsa-miR-608	PAR-CLIP	23592263
MIRT484964	hsa-miR-6747-5p	PAR-CLIP	23592263
MIRT484963	hsa-miR-6737-5p	PAR-CLIP	23592263
MIRT484962	hsa-miR-6812-5p	PAR-CLIP	23592263
MIRT484961	hsa-miR-6819-5p	PAR-CLIP	23592263
MIRT484960	hsa-miR-8060	PAR-CLIP	23592263
MIRT1472512	hsa-miR-2355-5p	CLIP-seq
MIRT1472513	hsa-miR-23a	CLIP-seq
MIRT1472514	hsa-miR-23b	CLIP-seq
MIRT1472515	hsa-miR-23c	CLIP-seq
MIRT1472516	hsa-miR-29a	CLIP-seq
MIRT1472517	hsa-miR-29b	CLIP-seq
MIRT1472518	hsa-miR-29c	CLIP-seq
MIRT1472519	hsa-miR-3173-3p	CLIP-seq
MIRT1472520	hsa-miR-3188	CLIP-seq
MIRT1472521	hsa-miR-3670	CLIP-seq
MIRT1472522	hsa-miR-3679-3p	CLIP-seq
MIRT1472523	hsa-miR-3929	CLIP-seq
MIRT1472524	hsa-miR-3938	CLIP-seq
MIRT1472525	hsa-miR-4279	CLIP-seq
MIRT1472526	hsa-miR-4419b	CLIP-seq
MIRT1472527	hsa-miR-4478	CLIP-seq
MIRT1472528	hsa-miR-455-5p	CLIP-seq
MIRT1472529	hsa-miR-4641	CLIP-seq
MIRT1472530	hsa-miR-4677-3p	CLIP-seq
MIRT1472531	hsa-miR-4695-5p	CLIP-seq
MIRT1472532	hsa-miR-550a	CLIP-seq
MIRT1472533	hsa-miR-626	CLIP-seq
MIRT1472534	hsa-miR-628-5p	CLIP-seq
MIRT1472535	hsa-miR-645	CLIP-seq
MIRT1472536	hsa-miR-670	CLIP-seq
MIRT1472537	hsa-miR-767-5p	CLIP-seq
MIRT1472538	hsa-miR-885-3p	CLIP-seq
MIRT2142317	hsa-miR-1288	CLIP-seq
MIRT1472512	hsa-miR-2355-5p	CLIP-seq
MIRT1472521	hsa-miR-3670	CLIP-seq
MIRT1472522	hsa-miR-3679-3p	CLIP-seq
MIRT1472523	hsa-miR-3929	CLIP-seq
MIRT2142318	hsa-miR-4264	CLIP-seq
MIRT2142319	hsa-miR-4276	CLIP-seq
MIRT1472525	hsa-miR-4279	CLIP-seq
MIRT1472526	hsa-miR-4419b	CLIP-seq
MIRT1472527	hsa-miR-4478	CLIP-seq
MIRT1472530	hsa-miR-4677-3p	CLIP-seq
MIRT1472533	hsa-miR-626	CLIP-seq
MIRT1472535	hsa-miR-645	CLIP-seq
MIRT2142318	hsa-miR-4264	CLIP-seq
MIRT2396640	hsa-miR-1293	CLIP-seq
MIRT2396641	hsa-miR-4455	CLIP-seq
MIRT2396642	hsa-miR-4483	CLIP-seq
MIRT2396643	hsa-miR-4519	CLIP-seq
MIRT2396644	hsa-miR-541	CLIP-seq
MIRT2396645	hsa-miR-609	CLIP-seq
MIRT2396646	hsa-miR-654-5p	CLIP-seq
MIRT2462835	hsa-miR-24	CLIP-seq
MIRT2462836	hsa-miR-4437	CLIP-seq
MIRT2462837	hsa-miR-4691-3p	CLIP-seq
MIRT2656897	hsa-miR-1200	CLIP-seq
MIRT2656898	hsa-miR-124	CLIP-seq
MIRT2656899	hsa-miR-1294	CLIP-seq
MIRT2656900	hsa-miR-1321	CLIP-seq
MIRT2656901	hsa-miR-141	CLIP-seq
MIRT2656902	hsa-miR-1912	CLIP-seq
MIRT2656903	hsa-miR-200a	CLIP-seq
MIRT1472513	hsa-miR-23a	CLIP-seq
MIRT1472514	hsa-miR-23b	CLIP-seq
MIRT1472515	hsa-miR-23c	CLIP-seq
MIRT2656904	hsa-miR-2467-5p	CLIP-seq
MIRT1472519	hsa-miR-3173-3p	CLIP-seq
MIRT1472520	hsa-miR-3188	CLIP-seq
MIRT2656905	hsa-miR-3200-5p	CLIP-seq
MIRT2656906	hsa-miR-3607-5p	CLIP-seq
MIRT1472521	hsa-miR-3670	CLIP-seq
MIRT2656907	hsa-miR-3692	CLIP-seq
MIRT2656908	hsa-miR-3915	CLIP-seq
MIRT2656909	hsa-miR-3928	CLIP-seq
MIRT2656910	hsa-miR-3975	CLIP-seq
MIRT2656911	hsa-miR-4316	CLIP-seq
MIRT2656912	hsa-miR-4324	CLIP-seq
MIRT2656913	hsa-miR-4419a	CLIP-seq
MIRT2656914	hsa-miR-4436b-5p	CLIP-seq
MIRT2656915	hsa-miR-4459	CLIP-seq
MIRT2656916	hsa-miR-4462	CLIP-seq
MIRT2656917	hsa-miR-4476	CLIP-seq
MIRT2656918	hsa-miR-4493	CLIP-seq
MIRT2656919	hsa-miR-4510	CLIP-seq
MIRT2656920	hsa-miR-4645-5p	CLIP-seq
MIRT2656921	hsa-miR-4668-5p	CLIP-seq
MIRT2656922	hsa-miR-4673	CLIP-seq
MIRT1472530	hsa-miR-4677-3p	CLIP-seq
MIRT2656923	hsa-miR-4682	CLIP-seq
MIRT1472531	hsa-miR-4695-5p	CLIP-seq
MIRT2656924	hsa-miR-4717-3p	CLIP-seq
MIRT2656925	hsa-miR-4722-5p	CLIP-seq
MIRT2656926	hsa-miR-4739	CLIP-seq
MIRT2656927	hsa-miR-4742-5p	CLIP-seq
MIRT2656928	hsa-miR-4756-5p	CLIP-seq
MIRT2656929	hsa-miR-4765	CLIP-seq
MIRT2656930	hsa-miR-4779	CLIP-seq
MIRT2656931	hsa-miR-483-3p	CLIP-seq
MIRT2656932	hsa-miR-485-5p	CLIP-seq
MIRT2656933	hsa-miR-506	CLIP-seq
MIRT2656934	hsa-miR-544b	CLIP-seq
MIRT2656935	hsa-miR-570	CLIP-seq
MIRT2656936	hsa-miR-602	CLIP-seq
MIRT2396645	hsa-miR-609	CLIP-seq
MIRT2656937	hsa-miR-625	CLIP-seq
MIRT1472534	hsa-miR-628-5p	CLIP-seq
MIRT2656938	hsa-miR-639	CLIP-seq
MIRT2656939	hsa-miR-642b	CLIP-seq
MIRT2656940	hsa-miR-720	CLIP-seq
MIRT2656898	hsa-miR-124	CLIP-seq
MIRT2694699	hsa-miR-1286	CLIP-seq
MIRT2142317	hsa-miR-1288	CLIP-seq
MIRT2656900	hsa-miR-1321	CLIP-seq
MIRT2656902	hsa-miR-1912	CLIP-seq
MIRT2694700	hsa-miR-2117	CLIP-seq
MIRT1472513	hsa-miR-23a	CLIP-seq
MIRT1472514	hsa-miR-23b	CLIP-seq
MIRT1472515	hsa-miR-23c	CLIP-seq
MIRT1472516	hsa-miR-29a	CLIP-seq
MIRT1472517	hsa-miR-29b	CLIP-seq
MIRT1472518	hsa-miR-29c	CLIP-seq
MIRT2694701	hsa-miR-3064-3p	CLIP-seq
MIRT2694702	hsa-miR-3169	CLIP-seq
MIRT2694703	hsa-miR-3176	CLIP-seq
MIRT2656906	hsa-miR-3607-5p	CLIP-seq
MIRT2694704	hsa-miR-3661	CLIP-seq
MIRT2694705	hsa-miR-3922-3p	CLIP-seq
MIRT2694706	hsa-miR-3925-3p	CLIP-seq
MIRT1472524	hsa-miR-3938	CLIP-seq
MIRT2694707	hsa-miR-4273	CLIP-seq
MIRT2656913	hsa-miR-4419a	CLIP-seq
MIRT2656915	hsa-miR-4459	CLIP-seq
MIRT2656916	hsa-miR-4462	CLIP-seq
MIRT2694708	hsa-miR-448	CLIP-seq
MIRT2656919	hsa-miR-4510	CLIP-seq
MIRT2694709	hsa-miR-4514	CLIP-seq
MIRT2694710	hsa-miR-4520a-5p	CLIP-seq
MIRT2694711	hsa-miR-4520b-5p	CLIP-seq
MIRT2656920	hsa-miR-4645-5p	CLIP-seq
MIRT2656921	hsa-miR-4668-5p	CLIP-seq
MIRT2656922	hsa-miR-4673	CLIP-seq
MIRT2694712	hsa-miR-4692	CLIP-seq
MIRT2656924	hsa-miR-4717-3p	CLIP-seq
MIRT2656925	hsa-miR-4722-5p	CLIP-seq
MIRT2656926	hsa-miR-4739	CLIP-seq
MIRT2656927	hsa-miR-4742-5p	CLIP-seq
MIRT2656928	hsa-miR-4756-5p	CLIP-seq
MIRT2694713	hsa-miR-4757-5p	CLIP-seq
MIRT2656930	hsa-miR-4779	CLIP-seq
MIRT2656933	hsa-miR-506	CLIP-seq
MIRT2694714	hsa-miR-515-5p	CLIP-seq
MIRT2656935	hsa-miR-570	CLIP-seq
MIRT2656936	hsa-miR-602	CLIP-seq
MIRT2396645	hsa-miR-609	CLIP-seq
MIRT2656937	hsa-miR-625	CLIP-seq
MIRT2694715	hsa-miR-631	CLIP-seq
MIRT1472536	hsa-miR-670	CLIP-seq
MIRT2694716	hsa-miR-766	CLIP-seq
MIRT1472537	hsa-miR-767-5p	CLIP-seq
MIRT2694717	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004849	Function	Uridine kinase activity	IBA
GO:0004849	Function	Uridine kinase activity	IDA	11306702
GO:0004849	Function	Uridine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	26871637, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0009224	Process	CMP biosynthetic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0043771	Function	Cytidine kinase activity	IDA	11306702
GO:0043771	Function	Cytidine kinase activity	IEA
GO:0044206	Process	UMP salvage	IDA	11306702
GO:0044206	Process	UMP salvage	IEA
GO:0044211	Process	CTP salvage	IDA	11306702
GO:0044211	Process	CTP salvage	IEA

Other IDs

• MIM: 609328
• HGNC: 14859
• e!Ensembl: ENSG00000130717

Protein

• UniProt ID: Q9HA47
• Protein name: Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1)
• Protein function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:1
• PDB: 2JEO , 2UVQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00485	PRK	25 → 219	Phosphoribulokinase / Uridine kinase family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11306702}.
• Sequence:

  MASAGGEDCESPAPEADRPHQRPFLIGVSGGTASGKSTVCEKIMELLGQNEVEQRQRKVV
  ILSQDRFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTH
  SRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVRRGRDL
  EQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDICKWHR
  GGSNGRSYKRTFSEPGDHPGMLTSGKRSHLESSSRPH

• Sequence length: 277

Pathways

KEGG Pathway	Reactome Pathway
Pyrimidine metabolism	Pyrimidine salvage
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism

Related Genes

Sort by: Blended Diseases Pathways Evidence source

UCKL1 4 shared pathwaysPyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Pyrimidine salvage Related via 4 shared pathways including Pyrimidine metabolism, Drug metabolism - other enzymes. TK1 4 shared pathwaysPyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Pyrimidine salvage Related via 4 shared pathways including Pyrimidine metabolism, Drug metabolism - other enzymes. TK2 4 shared pathwaysPyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Pyrimidine salvage Related via 4 shared pathways including Pyrimidine metabolism, Drug metabolism - other enzymes. UCK2 4 shared pathwaysPyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Pyrimidine salvage Related via 4 shared pathways including Pyrimidine metabolism, Drug metabolism - other enzymes. CDA 4 shared pathwaysPyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Pyrimidine salvage Related via 4 shared pathways including Pyrimidine metabolism, Drug metabolism - other enzymes.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
UCKL1	0	[]	4	["Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Pyrimidine salvage"]	0	[]
TK1	0	[]	4	["Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Pyrimidine salvage"]	0	[]
TK2	0	[]	4	["Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Pyrimidine salvage"]	0	[]
UCK2	0	[]	4	["Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Pyrimidine salvage"]	0	[]
CDA	0	[]	4	["Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Pyrimidine salvage"]	0	[]

Diseases Linked via Similar Genes

Gout Linked via 1 of 5 related genesUCKL1 Hepatocellular carcinoma Linked via 1 of 5 related genesTK1 Colorectal neoplasms Linked via 1 of 5 related genesTK1 Progressive external ophthalmoplegia Linked via 1 of 5 related genesTK2 Mitochondrial dna depletion syndrome Linked via 1 of 5 related genesTK2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Gout	1	["UCKL1"]
Hepatocellular carcinoma	1	["TK1"]
Colorectal neoplasms	1	["TK1"]
Progressive external ophthalmoplegia	1	["TK2"]
Mitochondrial dna depletion syndrome	1	["TK2"]