UBXN8 (UBX domain protein 8)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7993
• Gene name: UBX domain protein 8
• Gene symbol: UBXN8
• Synonyms (NCBI Gene): D8S2298E, REP8, UBXD6
• Chromosome: 8
• Chromosome location: 8p12
• Summary: p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic

miRNA Show/Hide all (64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032338	hsa-let-7b-5p	Proteomics	18668040
MIRT1472379	hsa-miR-127-5p	CLIP-seq
MIRT1472380	hsa-miR-155	CLIP-seq
MIRT1472381	hsa-miR-27a	CLIP-seq
MIRT1472382	hsa-miR-27b	CLIP-seq
MIRT1472383	hsa-miR-3120-3p	CLIP-seq
MIRT1472384	hsa-miR-3160-5p	CLIP-seq
MIRT1472385	hsa-miR-3691-3p	CLIP-seq
MIRT1472386	hsa-miR-376a	CLIP-seq
MIRT1472387	hsa-miR-376b	CLIP-seq
MIRT1472388	hsa-miR-4775	CLIP-seq
MIRT1472389	hsa-miR-4778-3p	CLIP-seq
MIRT1472390	hsa-miR-513a-5p	CLIP-seq
MIRT1472381	hsa-miR-27a	CLIP-seq
MIRT1472382	hsa-miR-27b	CLIP-seq
MIRT1472383	hsa-miR-3120-3p	CLIP-seq
MIRT2142296	hsa-miR-3670	CLIP-seq
MIRT2142297	hsa-miR-3973	CLIP-seq
MIRT2142298	hsa-miR-4659a-5p	CLIP-seq
MIRT2142299	hsa-miR-4659b-5p	CLIP-seq
MIRT2142300	hsa-miR-4769-3p	CLIP-seq
MIRT1472390	hsa-miR-513a-5p	CLIP-seq
MIRT2142301	hsa-miR-520g	CLIP-seq
MIRT2142302	hsa-miR-520h	CLIP-seq
MIRT2142303	hsa-miR-556-5p	CLIP-seq
MIRT2142304	hsa-miR-561	CLIP-seq
MIRT2142305	hsa-miR-922	CLIP-seq
MIRT2656806	hsa-miR-1207-3p	CLIP-seq
MIRT2656807	hsa-miR-1263	CLIP-seq
MIRT2656808	hsa-miR-1305	CLIP-seq
MIRT2656809	hsa-miR-141	CLIP-seq
MIRT2656810	hsa-miR-1911	CLIP-seq
MIRT2656811	hsa-miR-200a	CLIP-seq
MIRT2656812	hsa-miR-217	CLIP-seq
MIRT2656813	hsa-miR-3148	CLIP-seq
MIRT2656814	hsa-miR-3153	CLIP-seq
MIRT2656815	hsa-miR-3607-3p	CLIP-seq
MIRT2656816	hsa-miR-3662	CLIP-seq
MIRT2656817	hsa-miR-4251	CLIP-seq
MIRT2656818	hsa-miR-4418	CLIP-seq
MIRT2656819	hsa-miR-4646-5p	CLIP-seq
MIRT2656820	hsa-miR-4668-5p	CLIP-seq
MIRT2656821	hsa-miR-4714-3p	CLIP-seq
MIRT2656822	hsa-miR-509-3-5p	CLIP-seq
MIRT2656823	hsa-miR-509-5p	CLIP-seq
MIRT2656824	hsa-miR-539	CLIP-seq
MIRT2656825	hsa-miR-579	CLIP-seq
MIRT2656806	hsa-miR-1207-3p	CLIP-seq
MIRT2656808	hsa-miR-1305	CLIP-seq
MIRT2656809	hsa-miR-141	CLIP-seq
MIRT2656810	hsa-miR-1911	CLIP-seq
MIRT2656811	hsa-miR-200a	CLIP-seq
MIRT2656812	hsa-miR-217	CLIP-seq
MIRT2656813	hsa-miR-3148	CLIP-seq
MIRT2656814	hsa-miR-3153	CLIP-seq
MIRT2656817	hsa-miR-4251	CLIP-seq
MIRT2656818	hsa-miR-4418	CLIP-seq
MIRT2694698	hsa-miR-455-3p	CLIP-seq
MIRT2656819	hsa-miR-4646-5p	CLIP-seq
MIRT2656820	hsa-miR-4668-5p	CLIP-seq
MIRT2656821	hsa-miR-4714-3p	CLIP-seq
MIRT2656822	hsa-miR-509-3-5p	CLIP-seq
MIRT2656823	hsa-miR-509-5p	CLIP-seq
MIRT2656824	hsa-miR-539	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	ISS
GO:0005515	Function	Protein binding	IPI	18775313, 21949850, 29997244, 32296183, 32814053, 35271311
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	21949850
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0007338	Process	Single fertilization	TAS	9027507
GO:0016020	Component	Membrane	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	ISS
GO:0036503	Process	ERAD pathway	IEA
GO:0036503	Process	ERAD pathway	IMP	21949850
GO:0043130	Function	Ubiquitin binding	IBA

Other IDs

• MIM: 602155
• HGNC: 30307
• e!Ensembl: ENSG00000104691

Protein

• UniProt ID: O00124
• Protein name: UBX domain-containing protein 8 (Reproduction 8 protein) (Rep-8 protein) (UBX domain-containing protein 6)
• Protein function: Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00789	UBX	186 → 265	UBX domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed abundantly in ovary and testis, and weakly in all other tissues tested.
• Sequence:

  MASRGVVGIFFLSAVPLVCLELRRGIPDIGIKDFLLLCGRILLLLALLTLIISVTTSWLN
  SFKSPQVYLKEEEEKNEKRQKLVRKKQQEAQGEKASRYIENVLKPHQEMKLRKLEERFYQ
  MTGEAWKLSSGHKLGGDEGTSQTSFETSNREAAKSQNLPKPLTEFPSPAEQPTCKEIPDL
  PEEPSQTAEEVVTVALRCPSGNVLRRRFLKSYSSQVLFDWMTRIGYHISLYSLSTSFPRR
  PLAVEGGQSLEDIGITVDTVLILEEKEQTN

• Sequence length: 270

Pathways

KEGG Pathway:

Protein processing in endoplasmic reticulum

Related Genes

No strongly related genes found yet for UBXN8.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to UBXN8.