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Gene Gene information from NCBI Gene database.
Entrez ID 22888
Gene name U-box domain containing 5
Gene symbol UBOX5
Synonyms (NCBI Gene)
RNF37UBCE7IP5UIP5hUIP5
Chromosome 20
Chromosome location 20p13
Summary This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
miRNA miRNA information provided by mirtarbase database.
323 Show/Hide all (323)
miRTarBase ID miRNA Experiments Reference
MIRT052547 hsa-let-7a-5p CLASH 23622248
MIRT696882 hsa-miR-106a-5p HITS-CLIP 23313552
MIRT696881 hsa-miR-106b-5p HITS-CLIP 23313552
MIRT696880 hsa-miR-17-5p HITS-CLIP 23313552
MIRT696879 hsa-miR-20a-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22 Show/Hide all (22)
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IBA
GO:0000209 Process Protein polyubiquitination IEA
GO:0000209 Process Protein polyubiquitination ISS
GO:0004842 Function Ubiquitin-protein transferase activity IEA
GO:0005515 Function Protein binding IPI 16189514, 25416956, 27229929, 29892012, 31515488, 32296183, 32814053
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619675 17777 ENSG00000185019
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O94941
Protein name RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5)
Protein function May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04564 U-box 259 → 337 U-box domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in liver, heart, brain, kidney and testis. {ECO:0000269|PubMed:11435423}.
Sequence
MVINLCLPQFRPRIHCNKISADGYEVENLISEDLTKRSHGFRTEYFIKPPVYVTVSFPFN
VEICRINIDLTAGGGQNVTGLEMYTSASSSRVSWNTPQCRTLGPAEPSVPDKEAFTLVGK
VLLKNQSQVVFSHRGFKARPPFGAMEATLPSPAVVAQELWNKGALSLSHVAHLRICITHV
TGGGIPCIKRLEVWGQPAKTCSQEVIDSILLVTSENLPQDVALQAPALPMESDCDPGDQP
ESQQAPSSLQKLAEIIQDVPEEFLDPITLEIMPCPMLLPSGKVIDQSTLEKCNRSEATWG
RVPSDPFTGVAFTPHSQPLPHPSLKARIDHFLLQHSI
PGCHLLGRAQTALAVIPSSIVLP
SQKRKIEQAEHVPDSNFGVNASCFSATSPLVLPTTSEHTAKKMKATNEPSLTHMDCSTGP
LSHEQKLSQSLEIALASTLGSMPSFTARLTRGQLQHLGTRGSNTSWRPGTGSEQPGSILG
PECASCKRVFSPYFKKEPVYQLPCGHLLCRPCLGEKQRSLPMTCTACQRPVASQDVLRVH
F
Sequence length 541
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Ubiquitin mediated proteolysis Antigen processing: Ubiquitination & Proteasome degradation