Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs
Entrez ID	7316
Gene name	Ubiquitin C
Gene symbol	UBC
Synonyms (NCBI Gene)	HMG20
Chromosome	12
Chromosome location	12q24.31
Summary	This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiq

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miRTarBase ID	miRNA	Experiments	Reference
MIRT030628	hsa-miR-24-3p	qRT-PCR	19748357
MIRT050710	hsa-miR-18a-5p	CLASH	23622248
MIRT046896	hsa-miR-221-3p	CLASH	23622248
MIRT042909	hsa-miR-324-3p	CLASH	23622248
MIRT042909	hsa-miR-324-3p	CLASH	23622248
MIRT039711	hsa-miR-615-3p	CLASH	23622248
MIRT039711	hsa-miR-615-3p	CLASH	23622248
MIRT039075	hsa-miR-769-3p	CLASH	23622248
MIRT038409	hsa-miR-296-3p	CLASH	23622248
MIRT037302	hsa-miR-877-5p	CLASH	23622248
MIRT439367	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439366	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439367	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726202	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726200	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT726201	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726199	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT439366	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439367	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439367	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439367	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439367	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439367	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439367	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT726202	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726202	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726202	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726202	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726202	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726202	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT439366	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439366	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439366	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439366	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439366	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439366	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT726200	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726200	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726200	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726200	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726200	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726200	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726199	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726199	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726199	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726199	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726199	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726199	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726201	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726201	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726201	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726201	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726201	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726201	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT1466908	hsa-miR-106a	CLIP-seq
MIRT1466909	hsa-miR-106b	CLIP-seq
MIRT1466910	hsa-miR-130a	CLIP-seq
MIRT1466911	hsa-miR-130b	CLIP-seq
MIRT1466912	hsa-miR-17	CLIP-seq
MIRT1466913	hsa-miR-20a	CLIP-seq
MIRT1466914	hsa-miR-20b	CLIP-seq
MIRT1466915	hsa-miR-301a	CLIP-seq
MIRT1466916	hsa-miR-301b	CLIP-seq
MIRT1466917	hsa-miR-454	CLIP-seq
MIRT1466918	hsa-miR-488	CLIP-seq
MIRT1466919	hsa-miR-519a	CLIP-seq
MIRT1466920	hsa-miR-519d	CLIP-seq
MIRT1466921	hsa-miR-653	CLIP-seq
MIRT1466922	hsa-miR-93	CLIP-seq
MIRT1466908	hsa-miR-106a	CLIP-seq
MIRT1466909	hsa-miR-106b	CLIP-seq
MIRT1466910	hsa-miR-130a	CLIP-seq
MIRT1466911	hsa-miR-130b	CLIP-seq
MIRT1466912	hsa-miR-17	CLIP-seq
MIRT1466913	hsa-miR-20a	CLIP-seq
MIRT1466914	hsa-miR-20b	CLIP-seq
MIRT1466915	hsa-miR-301a	CLIP-seq
MIRT1466916	hsa-miR-301b	CLIP-seq
MIRT1466917	hsa-miR-454	CLIP-seq
MIRT1466918	hsa-miR-488	CLIP-seq
MIRT1466919	hsa-miR-519a	CLIP-seq
MIRT1466920	hsa-miR-519d	CLIP-seq
MIRT1466921	hsa-miR-653	CLIP-seq
MIRT1466922	hsa-miR-93	CLIP-seq

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Transcription factor	Regulation	Reference
SP1	Unknown	19733223
SP3	Unknown	19733223

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	8702753, 16256071, 16424905, 16482222, 16763556, 16810318, 16845370, 16874300, 16874301, 16936636, 16996503, 17006543, 17028573, 17067581, 17070805, 17110928, 17139261, 17159902, 17170702, 17183367, 17255943, 17268548, 17290220, 17304240, 17318174, 17318178, 17320083, 17363902, 1736
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0010008	Component	Endosome membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0019941	Process	Modification-dependent protein catabolic process	IBA
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0031386	Function	Protein tag activity	IBA
GO:0031625	Function	Ubiquitin protein ligase binding	IBA
GO:0031982	Component	Vesicle	HDA	19190083
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
191340	12468	ENSG00000150991

P0CG48

Protein name

Polyubiquitin-C [Cleaved into: Ubiquitin]

Protein function

[Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys re

PDB

1C3T , 1CMX , 1D3Z , 1F9J , 1FXT , 1G6J , 1GJZ , 1NBF , 1OGW , 1Q5W , 1S1Q , 1SIF , 1TBE , 1UBI , 1UBQ , 1UD7 , 1XD3 , 1XQQ , 1YX5 , 1YX6 , 1ZGU , 2AYO , 2BGF , 2DEN , 2FUH , 2G45 , 2GBJ , 2GBK , 2GBM , 2GBN , 2GBR , 2GMI , 2HTH , 2IBI , 2J7Q , 2JF5 , 2JRI , 2JY6 , 2JZZ , 2K25 , 2K6D , 2K8B , 2K8C , 2KDF , 2KHW , 2KJH , 2KLG , 2KN5 , 2KX0 , 2L3Z , 2LD9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00240	ubiquitin	3 → 74	Ubiquitin family	Domain
PF00240	ubiquitin	79 → 150	Ubiquitin family	Domain
PF00240	ubiquitin	155 → 226	Ubiquitin family	Domain
PF00240	ubiquitin	231 → 302	Ubiquitin family	Domain
PF00240	ubiquitin	307 → 378	Ubiquitin family	Domain
PF00240	ubiquitin	383 → 454	Ubiquitin family	Domain
PF00240	ubiquitin	459 → 530	Ubiquitin family	Domain
PF00240	ubiquitin	535 → 606	Ubiquitin family	Domain
PF00240	ubiquitin	611 → 682	Ubiquitin family	Domain

Sequence

MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKA
KIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKT
ITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLR
LRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTL
SDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ
QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIE
NVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTL
TGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLH
LVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLED
GRTLSDYNIQKESTLHLVLRLRGGV

Sequence length

685

Interactions

View interactions

UBC (ubiquitin C)