TYW2 (tRNA wybutosine-synthesizing protein 2)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 55039
• Gene name: TRNA wybutosine-synthesizing protein 2
• Gene symbol: TYW2
• Synonyms (NCBI Gene): TRM12, TRMT12
• Chromosome: 8
• Chromosome location: 8q24.13

miRNA Show/Hide all (171)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1456689	hsa-miR-1226	CLIP-seq
MIRT1456690	hsa-miR-1269	CLIP-seq
MIRT1456691	hsa-miR-1269b	CLIP-seq
MIRT1456692	hsa-miR-1288	CLIP-seq
MIRT1456693	hsa-miR-150	CLIP-seq
MIRT1456694	hsa-miR-1914	CLIP-seq
MIRT1456695	hsa-miR-204	CLIP-seq
MIRT1456696	hsa-miR-211	CLIP-seq
MIRT1456697	hsa-miR-2964a-5p	CLIP-seq
MIRT1456698	hsa-miR-3064-3p	CLIP-seq
MIRT1456699	hsa-miR-3180-5p	CLIP-seq
MIRT1456700	hsa-miR-3545-3p	CLIP-seq
MIRT1456701	hsa-miR-3646	CLIP-seq
MIRT1456702	hsa-miR-3688-3p	CLIP-seq
MIRT1456703	hsa-miR-3690	CLIP-seq
MIRT1456704	hsa-miR-375	CLIP-seq
MIRT1456705	hsa-miR-378	CLIP-seq
MIRT1456706	hsa-miR-378b	CLIP-seq
MIRT1456707	hsa-miR-378c	CLIP-seq
MIRT1456708	hsa-miR-378d	CLIP-seq
MIRT1456709	hsa-miR-378e	CLIP-seq
MIRT1456710	hsa-miR-378f	CLIP-seq
MIRT1456711	hsa-miR-378h	CLIP-seq
MIRT1456712	hsa-miR-378i	CLIP-seq
MIRT1456713	hsa-miR-422a	CLIP-seq
MIRT1456714	hsa-miR-4475	CLIP-seq
MIRT1456715	hsa-miR-4477b	CLIP-seq
MIRT1456716	hsa-miR-4515	CLIP-seq
MIRT1456717	hsa-miR-4539	CLIP-seq
MIRT1456718	hsa-miR-4640-5p	CLIP-seq
MIRT1456719	hsa-miR-4652-3p	CLIP-seq
MIRT1456720	hsa-miR-4678	CLIP-seq
MIRT1456721	hsa-miR-4704-5p	CLIP-seq
MIRT1456722	hsa-miR-4713-5p	CLIP-seq
MIRT1456723	hsa-miR-4724-5p	CLIP-seq
MIRT1456724	hsa-miR-4726-5p	CLIP-seq
MIRT1456725	hsa-miR-4729	CLIP-seq
MIRT1456726	hsa-miR-4733-3p	CLIP-seq
MIRT1456727	hsa-miR-4738-3p	CLIP-seq
MIRT1456728	hsa-miR-4740-5p	CLIP-seq
MIRT1456729	hsa-miR-4755-5p	CLIP-seq
MIRT1456730	hsa-miR-4775	CLIP-seq
MIRT1456731	hsa-miR-490-3p	CLIP-seq
MIRT1456732	hsa-miR-520a-5p	CLIP-seq
MIRT1456733	hsa-miR-525-5p	CLIP-seq
MIRT1456734	hsa-miR-532-3p	CLIP-seq
MIRT1456735	hsa-miR-549	CLIP-seq
MIRT1456736	hsa-miR-579	CLIP-seq
MIRT1456737	hsa-miR-590-3p	CLIP-seq
MIRT1456738	hsa-miR-619	CLIP-seq
MIRT1456739	hsa-miR-623	CLIP-seq
MIRT1456740	hsa-miR-651	CLIP-seq
MIRT1456689	hsa-miR-1226	CLIP-seq
MIRT1456690	hsa-miR-1269	CLIP-seq
MIRT1456691	hsa-miR-1269b	CLIP-seq
MIRT1456692	hsa-miR-1288	CLIP-seq
MIRT1456699	hsa-miR-3180-5p	CLIP-seq
MIRT1456700	hsa-miR-3545-3p	CLIP-seq
MIRT2136871	hsa-miR-3673	CLIP-seq
MIRT1456703	hsa-miR-3690	CLIP-seq
MIRT2136872	hsa-miR-3691-3p	CLIP-seq
MIRT1456705	hsa-miR-378	CLIP-seq
MIRT1456706	hsa-miR-378b	CLIP-seq
MIRT1456707	hsa-miR-378c	CLIP-seq
MIRT1456708	hsa-miR-378d	CLIP-seq
MIRT1456709	hsa-miR-378e	CLIP-seq
MIRT1456710	hsa-miR-378f	CLIP-seq
MIRT1456711	hsa-miR-378h	CLIP-seq
MIRT1456712	hsa-miR-378i	CLIP-seq
MIRT1456713	hsa-miR-422a	CLIP-seq
MIRT1456715	hsa-miR-4477b	CLIP-seq
MIRT1456716	hsa-miR-4515	CLIP-seq
MIRT1456717	hsa-miR-4539	CLIP-seq
MIRT1456723	hsa-miR-4724-5p	CLIP-seq
MIRT1456726	hsa-miR-4733-3p	CLIP-seq
MIRT1456728	hsa-miR-4740-5p	CLIP-seq
MIRT2136873	hsa-miR-4760-3p	CLIP-seq
MIRT1456731	hsa-miR-490-3p	CLIP-seq
MIRT1456732	hsa-miR-520a-5p	CLIP-seq
MIRT1456733	hsa-miR-525-5p	CLIP-seq
MIRT1456735	hsa-miR-549	CLIP-seq
MIRT1456738	hsa-miR-619	CLIP-seq
MIRT2136874	hsa-miR-885-5p	CLIP-seq
MIRT2357655	hsa-miR-1245b-3p	CLIP-seq
MIRT2357656	hsa-miR-140-3p	CLIP-seq
MIRT1456693	hsa-miR-150	CLIP-seq
MIRT2357657	hsa-miR-25	CLIP-seq
MIRT2357658	hsa-miR-302f	CLIP-seq
MIRT1456699	hsa-miR-3180-5p	CLIP-seq
MIRT2357659	hsa-miR-32	CLIP-seq
MIRT1456700	hsa-miR-3545-3p	CLIP-seq
MIRT2357660	hsa-miR-363	CLIP-seq
MIRT2357661	hsa-miR-3661	CLIP-seq
MIRT2357662	hsa-miR-3663-5p	CLIP-seq
MIRT2357663	hsa-miR-367	CLIP-seq
MIRT2136871	hsa-miR-3673	CLIP-seq
MIRT1456703	hsa-miR-3690	CLIP-seq
MIRT2136872	hsa-miR-3691-3p	CLIP-seq
MIRT1456715	hsa-miR-4477b	CLIP-seq
MIRT2357664	hsa-miR-4638-3p	CLIP-seq
MIRT1456720	hsa-miR-4678	CLIP-seq
MIRT1456722	hsa-miR-4713-5p	CLIP-seq
MIRT1456723	hsa-miR-4724-5p	CLIP-seq
MIRT1456727	hsa-miR-4738-3p	CLIP-seq
MIRT2136873	hsa-miR-4760-3p	CLIP-seq
MIRT1456732	hsa-miR-520a-5p	CLIP-seq
MIRT1456733	hsa-miR-525-5p	CLIP-seq
MIRT1456734	hsa-miR-532-3p	CLIP-seq
MIRT2357665	hsa-miR-587	CLIP-seq
MIRT1456738	hsa-miR-619	CLIP-seq
MIRT2357666	hsa-miR-631	CLIP-seq
MIRT2136874	hsa-miR-885-5p	CLIP-seq
MIRT2357667	hsa-miR-92a	CLIP-seq
MIRT2357668	hsa-miR-92b	CLIP-seq
MIRT2462394	hsa-miR-3617	CLIP-seq
MIRT1456725	hsa-miR-4729	CLIP-seq
MIRT2462395	hsa-miR-641	CLIP-seq
MIRT1456740	hsa-miR-651	CLIP-seq
MIRT2462394	hsa-miR-3617	CLIP-seq
MIRT1456725	hsa-miR-4729	CLIP-seq
MIRT2462395	hsa-miR-641	CLIP-seq
MIRT2357655	hsa-miR-1245b-3p	CLIP-seq
MIRT1456693	hsa-miR-150	CLIP-seq
MIRT2357657	hsa-miR-25	CLIP-seq
MIRT2357658	hsa-miR-302f	CLIP-seq
MIRT1456699	hsa-miR-3180-5p	CLIP-seq
MIRT2357659	hsa-miR-32	CLIP-seq
MIRT2462394	hsa-miR-3617	CLIP-seq
MIRT2357660	hsa-miR-363	CLIP-seq
MIRT2357663	hsa-miR-367	CLIP-seq
MIRT2136871	hsa-miR-3673	CLIP-seq
MIRT1456718	hsa-miR-4640-5p	CLIP-seq
MIRT1456720	hsa-miR-4678	CLIP-seq
MIRT1456722	hsa-miR-4713-5p	CLIP-seq
MIRT1456724	hsa-miR-4726-5p	CLIP-seq
MIRT1456725	hsa-miR-4729	CLIP-seq
MIRT1456727	hsa-miR-4738-3p	CLIP-seq
MIRT2136873	hsa-miR-4760-3p	CLIP-seq
MIRT1456732	hsa-miR-520a-5p	CLIP-seq
MIRT1456733	hsa-miR-525-5p	CLIP-seq
MIRT1456734	hsa-miR-532-3p	CLIP-seq
MIRT1456736	hsa-miR-579	CLIP-seq
MIRT2462395	hsa-miR-641	CLIP-seq
MIRT1456740	hsa-miR-651	CLIP-seq
MIRT2357667	hsa-miR-92a	CLIP-seq
MIRT2357668	hsa-miR-92b	CLIP-seq
MIRT2357655	hsa-miR-1245b-3p	CLIP-seq
MIRT1456693	hsa-miR-150	CLIP-seq
MIRT2357657	hsa-miR-25	CLIP-seq
MIRT2357658	hsa-miR-302f	CLIP-seq
MIRT1456699	hsa-miR-3180-5p	CLIP-seq
MIRT2357659	hsa-miR-32	CLIP-seq
MIRT2462394	hsa-miR-3617	CLIP-seq
MIRT2357660	hsa-miR-363	CLIP-seq
MIRT2357663	hsa-miR-367	CLIP-seq
MIRT2136871	hsa-miR-3673	CLIP-seq
MIRT1456718	hsa-miR-4640-5p	CLIP-seq
MIRT1456720	hsa-miR-4678	CLIP-seq
MIRT1456722	hsa-miR-4713-5p	CLIP-seq
MIRT1456724	hsa-miR-4726-5p	CLIP-seq
MIRT1456725	hsa-miR-4729	CLIP-seq
MIRT1456727	hsa-miR-4738-3p	CLIP-seq
MIRT2136873	hsa-miR-4760-3p	CLIP-seq
MIRT1456732	hsa-miR-520a-5p	CLIP-seq
MIRT1456733	hsa-miR-525-5p	CLIP-seq
MIRT1456734	hsa-miR-532-3p	CLIP-seq
MIRT1456736	hsa-miR-579	CLIP-seq
MIRT2462395	hsa-miR-641	CLIP-seq
MIRT1456740	hsa-miR-651	CLIP-seq
MIRT2357667	hsa-miR-92a	CLIP-seq
MIRT2357668	hsa-miR-92b	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0006400	Process	TRNA modification	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0008175	Function	TRNA methyltransferase activity	IBA
GO:0016740	Function	Transferase activity	IEA
GO:0030488	Process	TRNA methylation	IBA
GO:0031591	Process	Wybutosine biosynthetic process	IBA
GO:0102522	Function	TRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity	IEA

Other IDs

• MIM: 611244
• HGNC: 26091
• e!Ensembl: ENSG00000183665

Protein

• UniProt ID: Q53H54
• Protein name: tRNA wybutosine-synthesizing protein 2 homolog (tRNA-yW-synthesizing protein 2) (EC 2.5.1.114) (tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase)
• Protein function: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenyl
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02475	Met_10	135 → 336	Met-10+ like-protein	Family

• Sequence:

  MRENVVVSNMERESGKPVAVVAVVTEPWFTQRYREYLQRQKLFDTQHRVEKMPDGSVALP
  VLGETLPEQHLQELRNRVAPGSPCMLTQLPDPVPSKRAQGCSPAQKLCLEVSRWVEGRGV
  KWSAELEADLPRSWQRHGNLLLLSEDCFQAKQWKNLGPELWETVALALGVQRLAKRGRVS
  PDGTRTPAVTLLLGDHGWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVD
  LYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRKLKLS
  NIADRVILGLIPSSEEGWPIACQVLRQDAGGILHIHQNVESFPGKNLQALGVSKVEKEHW
  LYPQQITTNQWKNGATRDSRGKMLSPATKPEWQRWAESAETRIATLLQQVHGKPWKTQIL
  HIQPVKSYAPHVDHIVLDLECCPCPSVG

• Sequence length: 448

Related Genes

No strongly related genes found yet for TYW2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TYW2.