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Gene Gene information from NCBI Gene database.
Entrez ID 219743
Gene name Trypsin like peroxisomal matrix peptidase 1
Gene symbol TYSND1
Synonyms (NCBI Gene)
NET41
Chromosome 10
Chromosome location 10q22.1
Summary This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal perox
miRNA miRNA information provided by mirtarbase database.
332 Show/Hide all (332)
miRTarBase ID miRNA Experiments Reference
MIRT020801 hsa-miR-155-5p Proteomics 18668040
MIRT048895 hsa-miR-93-5p CLASH 23622248
MIRT1465697 hsa-miR-1183 CLIP-seq
MIRT1465698 hsa-miR-1228 CLIP-seq
MIRT1465699 hsa-miR-124 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25 Show/Hide all (25)
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IPI 22002062
GO:0004252 Function Serine-type endopeptidase activity EXP 22002062
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0004252 Function Serine-type endopeptidase activity IMP 22002062
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611017 28531 ENSG00000156521
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q2T9J0
Protein name Peroxisomal leader peptide-processing protease (EC 3.4.21.-) (Trypsin domain-containing protein 1) [Cleaved into: Peroxisomal leader peptide-processing protease, 15 kDa form; Peroxisomal leader peptide-processing protease, 45 kDa form]
Protein function Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13365 Trypsin_2 357 → 496 Domain
Sequence
MRRQWGSAMRAAEQAGCMVSASRAGQPEAGPWSCSGVILSRSPGLVLCHGGIFVPFLRAG
SEVLTAAGAVFLPGDSCRDDLRLHVQWAPTAAGPGGGAERGRPGLCTPQCASLEPGPPAP
SRGRPLQPRLPAELLLLLSCPAFWAHFARLFGDEAAEQWRFSSAARDDEVSEDEEADQLR
ALGWFALLGVRLGQEEVEEERGPAMAVSPLGAVPKGAPLLVCGSPFGAFCPDIFLNTLSC
GVLSNVAGPLLLTDARCLPGTEGGGVFTARPAGALVALVVAPLCWKAGEWVGFTLLCAAA
PLFRAARDALHRLPHSTAALAALLPPEVGVPWGLPLRDSGPLWAAAAVLVECGTVWGSGV
AVAPRLVVTCRHVSPREAARVLVRSTTPKSVAIWGRVVFATQETCPYDIAVVSLEEDLDD
VPIPVPAEHFHEGEAVSVVGFGVFGQSCGPSVTSGILSAVVQVNGTPVMLQTTCAVHSGS
SGGPLFSNHSGNLLGI
ITSNTRDNNTGATYPHLNFSIPITVLQPALQQYSQTQDLGGLRE
LDRAAEPVRVVWRLQRPLAEAPRSKL
Sequence length 566
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Peroxisomal protein import
TYSND1 cleaves peroxisomal proteins