TXNDC12 (thioredoxin domain containing 12)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 51060 |
| Gene name | Thioredoxin domain containing 12 |
| Gene symbol | TXNDC12 |
| Synonyms (NCBI Gene) |
AG1AGR1ERP16ERP18ERP19PDIA16TLP19hAG-1hTLP19
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| Chromosome | 1 |
| Chromosome location | 1p32.3 |
| Summary | This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmi |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O95881 | ||||||||||
| Protein name | Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19) | ||||||||||
| Protein function | Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity. | ||||||||||
| PDB | 1SEN , 2K8V | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:14557066}. | ||||||||||
| Sequence |
METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVI |
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| Sequence length | 172 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Related Genes
Genes most often co-reported with TXNDC12 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to TXNDC12 (see Related Genes above), that are NOT already directly curated for TXNDC12 itself -- a lead worth checking, not a confirmed association.
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