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Gene Gene information from NCBI Gene database.
Entrez ID 51060
Gene name Thioredoxin domain containing 12
Gene symbol TXNDC12
Synonyms (NCBI Gene)
AG1AGR1ERP16ERP18ERP19PDIA16TLP19hAG-1hTLP19
Chromosome 1
Chromosome location 1p32.3
Summary This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmi
miRNA miRNA information provided by mirtarbase database.
324 Show/Hide all (324)
miRTarBase ID miRNA Experiments Reference
MIRT001490 hsa-miR-155-5p pSILAC 18668040
MIRT001490 hsa-miR-155-5p Proteomics;Other 18668040
MIRT710003 hsa-miR-580-5p HITS-CLIP 19536157
MIRT710002 hsa-miR-138-1-3p HITS-CLIP 19536157
MIRT710001 hsa-miR-4772-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10 Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 31515488, 32296183
GO:0005783 Component Endoplasmic reticulum IBA
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005788 Component Endoplasmic reticulum lumen IDA 12761212, 18628206
GO:0005788 Component Endoplasmic reticulum lumen IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609448 24626 ENSG00000117862
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95881
Protein name Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19)
Protein function Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.
PDB 1SEN , 2K8V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13899 Thioredoxin_7 39 → 120 Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:14557066}.
Sequence
METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVI
IHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDP

SGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL
Sequence length 172
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
Glutathione metabolism
Metabolic pathways