TTLL4 (tubulin tyrosine ligase like 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9654
• Gene name: Tubulin tyrosine ligase like 4
• Gene symbol: TTLL4
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2q35

miRNA Show/Hide all (190)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027603	hsa-miR-98-5p	Microarray	19088304
MIRT037173	hsa-miR-877-3p	CLASH	23622248
MIRT1462409	hsa-let-7a	CLIP-seq
MIRT1462410	hsa-let-7b	CLIP-seq
MIRT1462411	hsa-let-7c	CLIP-seq
MIRT1462412	hsa-let-7d	CLIP-seq
MIRT1462413	hsa-let-7e	CLIP-seq
MIRT1462414	hsa-let-7f	CLIP-seq
MIRT1462415	hsa-let-7g	CLIP-seq
MIRT1462416	hsa-let-7i	CLIP-seq
MIRT1462417	hsa-miR-1270	CLIP-seq
MIRT1462418	hsa-miR-1285	CLIP-seq
MIRT1462419	hsa-miR-1294	CLIP-seq
MIRT1462420	hsa-miR-1321	CLIP-seq
MIRT1462421	hsa-miR-1343	CLIP-seq
MIRT1462422	hsa-miR-202	CLIP-seq
MIRT1462423	hsa-miR-214	CLIP-seq
MIRT1462424	hsa-miR-2467-3p	CLIP-seq
MIRT1462425	hsa-miR-3119	CLIP-seq
MIRT1462426	hsa-miR-3123	CLIP-seq
MIRT1462427	hsa-miR-3125	CLIP-seq
MIRT1462428	hsa-miR-3140-3p	CLIP-seq
MIRT1462429	hsa-miR-3187-5p	CLIP-seq
MIRT1462430	hsa-miR-3188	CLIP-seq
MIRT1462431	hsa-miR-3619-5p	CLIP-seq
MIRT1462432	hsa-miR-3667-3p	CLIP-seq
MIRT1462433	hsa-miR-3916	CLIP-seq
MIRT1462434	hsa-miR-3925-5p	CLIP-seq
MIRT1462435	hsa-miR-3927	CLIP-seq
MIRT1462436	hsa-miR-3976	CLIP-seq
MIRT1462437	hsa-miR-4268	CLIP-seq
MIRT1462438	hsa-miR-4277	CLIP-seq
MIRT1462439	hsa-miR-4325	CLIP-seq
MIRT1462440	hsa-miR-4419a	CLIP-seq
MIRT1462441	hsa-miR-4448	CLIP-seq
MIRT1462442	hsa-miR-4458	CLIP-seq
MIRT1462443	hsa-miR-4500	CLIP-seq
MIRT1462444	hsa-miR-4510	CLIP-seq
MIRT1462445	hsa-miR-4531	CLIP-seq
MIRT1462446	hsa-miR-4641	CLIP-seq
MIRT1462447	hsa-miR-4650-3p	CLIP-seq
MIRT1462448	hsa-miR-4684-3p	CLIP-seq
MIRT1462449	hsa-miR-4690-5p	CLIP-seq
MIRT1462450	hsa-miR-4716-5p	CLIP-seq
MIRT1462451	hsa-miR-4739	CLIP-seq
MIRT1462452	hsa-miR-4756-5p	CLIP-seq
MIRT1462453	hsa-miR-4779	CLIP-seq
MIRT1462454	hsa-miR-518d-5p	CLIP-seq
MIRT1462455	hsa-miR-519b-5p	CLIP-seq
MIRT1462456	hsa-miR-519c-5p	CLIP-seq
MIRT1462457	hsa-miR-520c-5p	CLIP-seq
MIRT1462458	hsa-miR-526a	CLIP-seq
MIRT1462459	hsa-miR-612	CLIP-seq
MIRT1462460	hsa-miR-620	CLIP-seq
MIRT1462461	hsa-miR-627	CLIP-seq
MIRT1462462	hsa-miR-761	CLIP-seq
MIRT1462463	hsa-miR-877	CLIP-seq
MIRT1462464	hsa-miR-924	CLIP-seq
MIRT1462465	hsa-miR-98	CLIP-seq
MIRT1462409	hsa-let-7a	CLIP-seq
MIRT1462410	hsa-let-7b	CLIP-seq
MIRT1462411	hsa-let-7c	CLIP-seq
MIRT1462412	hsa-let-7d	CLIP-seq
MIRT1462413	hsa-let-7e	CLIP-seq
MIRT1462414	hsa-let-7f	CLIP-seq
MIRT1462415	hsa-let-7g	CLIP-seq
MIRT1462416	hsa-let-7i	CLIP-seq
MIRT2139082	hsa-miR-1208	CLIP-seq
MIRT1462418	hsa-miR-1285	CLIP-seq
MIRT1462419	hsa-miR-1294	CLIP-seq
MIRT1462420	hsa-miR-1321	CLIP-seq
MIRT1462421	hsa-miR-1343	CLIP-seq
MIRT1462422	hsa-miR-202	CLIP-seq
MIRT1462423	hsa-miR-214	CLIP-seq
MIRT1462424	hsa-miR-2467-3p	CLIP-seq
MIRT1462427	hsa-miR-3125	CLIP-seq
MIRT2139083	hsa-miR-3126-5p	CLIP-seq
MIRT2139084	hsa-miR-3150b-3p	CLIP-seq
MIRT1462429	hsa-miR-3187-5p	CLIP-seq
MIRT1462430	hsa-miR-3188	CLIP-seq
MIRT2139085	hsa-miR-3613-3p	CLIP-seq
MIRT1462431	hsa-miR-3619-5p	CLIP-seq
MIRT2139086	hsa-miR-3663-5p	CLIP-seq
MIRT2139087	hsa-miR-3664-5p	CLIP-seq
MIRT1462433	hsa-miR-3916	CLIP-seq
MIRT2139088	hsa-miR-3921	CLIP-seq
MIRT1462435	hsa-miR-3927	CLIP-seq
MIRT2139089	hsa-miR-3936	CLIP-seq
MIRT1462437	hsa-miR-4268	CLIP-seq
MIRT1462438	hsa-miR-4277	CLIP-seq
MIRT2139090	hsa-miR-4278	CLIP-seq
MIRT1462440	hsa-miR-4419a	CLIP-seq
MIRT1462441	hsa-miR-4448	CLIP-seq
MIRT1462442	hsa-miR-4458	CLIP-seq
MIRT2139091	hsa-miR-4463	CLIP-seq
MIRT2139092	hsa-miR-4494	CLIP-seq
MIRT1462443	hsa-miR-4500	CLIP-seq
MIRT1462444	hsa-miR-4510	CLIP-seq
MIRT2139093	hsa-miR-452	CLIP-seq
MIRT2139094	hsa-miR-4527	CLIP-seq
MIRT2139095	hsa-miR-4539	CLIP-seq
MIRT1462446	hsa-miR-4641	CLIP-seq
MIRT2139096	hsa-miR-4649-3p	CLIP-seq
MIRT1462447	hsa-miR-4650-3p	CLIP-seq
MIRT2139097	hsa-miR-4653-5p	CLIP-seq
MIRT2139098	hsa-miR-4676-3p	CLIP-seq
MIRT2139099	hsa-miR-4689	CLIP-seq
MIRT1462449	hsa-miR-4690-5p	CLIP-seq
MIRT2139100	hsa-miR-4714-5p	CLIP-seq
MIRT2139101	hsa-miR-4716-3p	CLIP-seq
MIRT1462451	hsa-miR-4739	CLIP-seq
MIRT1462452	hsa-miR-4756-5p	CLIP-seq
MIRT1462453	hsa-miR-4779	CLIP-seq
MIRT2139102	hsa-miR-4784	CLIP-seq
MIRT2139103	hsa-miR-4802-3p	CLIP-seq
MIRT2139104	hsa-miR-488	CLIP-seq
MIRT2139105	hsa-miR-499a-5p	CLIP-seq
MIRT1462454	hsa-miR-518d-5p	CLIP-seq
MIRT1462455	hsa-miR-519b-5p	CLIP-seq
MIRT1462456	hsa-miR-519c-5p	CLIP-seq
MIRT1462457	hsa-miR-520c-5p	CLIP-seq
MIRT1462458	hsa-miR-526a	CLIP-seq
MIRT1462459	hsa-miR-612	CLIP-seq
MIRT1462461	hsa-miR-627	CLIP-seq
MIRT1462462	hsa-miR-761	CLIP-seq
MIRT1462463	hsa-miR-877	CLIP-seq
MIRT1462464	hsa-miR-924	CLIP-seq
MIRT1462465	hsa-miR-98	CLIP-seq
MIRT1462409	hsa-let-7a	CLIP-seq
MIRT1462410	hsa-let-7b	CLIP-seq
MIRT1462411	hsa-let-7c	CLIP-seq
MIRT1462412	hsa-let-7d	CLIP-seq
MIRT1462413	hsa-let-7e	CLIP-seq
MIRT1462414	hsa-let-7f	CLIP-seq
MIRT1462415	hsa-let-7g	CLIP-seq
MIRT1462416	hsa-let-7i	CLIP-seq
MIRT1462417	hsa-miR-1270	CLIP-seq
MIRT1462418	hsa-miR-1285	CLIP-seq
MIRT1462419	hsa-miR-1294	CLIP-seq
MIRT1462420	hsa-miR-1321	CLIP-seq
MIRT1462421	hsa-miR-1343	CLIP-seq
MIRT1462422	hsa-miR-202	CLIP-seq
MIRT1462424	hsa-miR-2467-3p	CLIP-seq
MIRT1462425	hsa-miR-3119	CLIP-seq
MIRT1462427	hsa-miR-3125	CLIP-seq
MIRT1462428	hsa-miR-3140-3p	CLIP-seq
MIRT1462429	hsa-miR-3187-5p	CLIP-seq
MIRT1462430	hsa-miR-3188	CLIP-seq
MIRT1462433	hsa-miR-3916	CLIP-seq
MIRT1462435	hsa-miR-3927	CLIP-seq
MIRT1462437	hsa-miR-4268	CLIP-seq
MIRT1462438	hsa-miR-4277	CLIP-seq
MIRT1462440	hsa-miR-4419a	CLIP-seq
MIRT1462441	hsa-miR-4448	CLIP-seq
MIRT1462442	hsa-miR-4458	CLIP-seq
MIRT2139091	hsa-miR-4463	CLIP-seq
MIRT2139092	hsa-miR-4494	CLIP-seq
MIRT1462443	hsa-miR-4500	CLIP-seq
MIRT1462444	hsa-miR-4510	CLIP-seq
MIRT1462445	hsa-miR-4531	CLIP-seq
MIRT1462446	hsa-miR-4641	CLIP-seq
MIRT2139096	hsa-miR-4649-3p	CLIP-seq
MIRT1462447	hsa-miR-4650-3p	CLIP-seq
MIRT1462451	hsa-miR-4739	CLIP-seq
MIRT1462452	hsa-miR-4756-5p	CLIP-seq
MIRT1462453	hsa-miR-4779	CLIP-seq
MIRT2139105	hsa-miR-499a-5p	CLIP-seq
MIRT1462454	hsa-miR-518d-5p	CLIP-seq
MIRT1462455	hsa-miR-519b-5p	CLIP-seq
MIRT1462456	hsa-miR-519c-5p	CLIP-seq
MIRT1462457	hsa-miR-520c-5p	CLIP-seq
MIRT1462458	hsa-miR-526a	CLIP-seq
MIRT1462459	hsa-miR-612	CLIP-seq
MIRT1462460	hsa-miR-620	CLIP-seq
MIRT1462461	hsa-miR-627	CLIP-seq
MIRT1462463	hsa-miR-877	CLIP-seq
MIRT1462464	hsa-miR-924	CLIP-seq
MIRT1462465	hsa-miR-98	CLIP-seq
MIRT2462641	hsa-miR-296-5p	CLIP-seq
MIRT2462642	hsa-miR-3918	CLIP-seq
MIRT2462643	hsa-miR-4685-5p	CLIP-seq
MIRT2462644	hsa-miR-4733-3p	CLIP-seq
MIRT2462645	hsa-miR-512-5p	CLIP-seq
MIRT2462646	hsa-miR-545	CLIP-seq
MIRT2462641	hsa-miR-296-5p	CLIP-seq
MIRT2462642	hsa-miR-3918	CLIP-seq
MIRT2462643	hsa-miR-4685-5p	CLIP-seq
MIRT2462644	hsa-miR-4733-3p	CLIP-seq
MIRT2462645	hsa-miR-512-5p	CLIP-seq
MIRT2462646	hsa-miR-545	CLIP-seq

Gene ontology (GO) Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IEA
GO:0015631	Function	Tubulin binding	IBA
GO:0015631	Function	Tubulin binding	IEA
GO:0015631	Function	Tubulin binding	ISS	21074048
GO:0016874	Function	Ligase activity	IEA
GO:0018095	Process	Protein polyglutamylation	ISS	21074048
GO:0018200	Process	Peptidyl-glutamic acid modification	ISS
GO:0036064	Component	Ciliary basal body	IBA
GO:0036064	Component	Ciliary basal body	IEA
GO:0042995	Component	Cell projection	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070739	Function	Protein-glutamic acid ligase activity	IEA
GO:0070739	Function	Protein-glutamic acid ligase activity	ISS
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IBA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IEA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	ISS
GO:0070740	Function	Tubulin-glutamic acid ligase activity	TAS
GO:0097731	Component	9+0 non-motile cilium	IEA
GO:0106437	Function	Protein-glutamic acid ligase activity, initiating	IEA
GO:0120222	Process	Regulation of blastocyst development	IEA

Other IDs

• MIM: 618738
• HGNC: 28976
• e!Ensembl: ENSG00000135912

Protein

• UniProt ID: Q14679
• Protein name: Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4)
• Protein function: Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation re
• PDB: 5T6X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03133	TTL	650 → 945	Tubulin-tyrosine ligase family	Family

• Sequence:

  MASAGTQHYSIGLRQKNSFKQSGPSGTVPATPPEKPSEGRVWPQAHQQVKPIWKLEKKQV
  ETLSAGLGPGLLGVPPQPAYFFCPSTLCSSGTTAVIAGHSSSCYLHSLPDLFNSTLLYRR
  SSYRQKPYQQLESFCLRSSPSEKSPFSLPQKSLPVSLTANKATSSMVFSMAQPMASSSTE
  PYLCLAAAGENPSGKSLASAISGKIPSPLSSSYKPMLNNNSFMWPNSTPVPLLQTTQGLK
  PVSPPKIQPVSWHHSGGTGDCAPQPVDHKVPKSIGTVPADASAHIALSTASSHDTSTTSV
  ASSWYNRNNLAMRAEPLSCALDDSSDSQDPTKEIRFTEAVRKLTARGFEKMPRQGCQLEQ
  SSFLNPSFQWNVLNRSRRWKPPAVNQQFPQEDAGSVRRVLPGASDTLGLDNTVFCTKRIS
  IHLLASHASGLNHNPACESVIDSSAFGEGKAPGPPFPQTLGIANVATRLSSIQLGQSEKE
  RPEEARELDSSDRDISSATDLQPDQAETEDTEEELVDGLEDCCSRDENEEEEGDSECSSL
  SAVSPSESVAMISRSCMEILTKPLSNHEKVVRPALIYSLFPNVPPTIYFGTRDERVEKLP
  WEQRKLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPSFRSIREHQKLN
  HFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFPQSFILPQDAKLLRKAWESSSRQKWIV
  KPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIY
  LFSDGLVRFASCKYSPSMKSLGNKFMHLTNYSVNKKNAEYQANADEMACQGHKWALKALW
  NYLSQKGVNSDAIWEKIKDVVVKTIISSEPYVTSLLKMYVRRPYSCHELFGFDIMLDENL
  KPWVLEVNISPSLHSSSPLDISIKGQMIRDLLNLAGFVLPNAEDIISSPSSCSSSTTSLP
  TSPGDKCRMAPEHVTAQKMKKAYYLTQKIPDQDFYASVLDVLTPDDVRILVEMEDEFSRR
  GQFERIFPSHISSRYLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLRSWCYKGFHMGVV
  SDSAPVWSLPTSLLTISKDDVILNAFSKSETSKLGKQSSCEVSLLLSEDGTTPKSKKTQA
  GLSPYPQKPSSSKDSEDTSKEPSLSTQTLPVIKCSGQTSRLSASSTFQSISDSLLAVSP

• Sequence length: 1199

Pathways

Reactome Pathway:

Carboxyterminal post-translational modifications of tubulin

Related Genes

No strongly related genes found yet for TTLL4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TTLL4.